Insomnia and sleep duration on COVID-19 susceptibility and hospitalization: A Mendelian randomization study
BackgroundSleep disturbance including insomnia and sleep duration is associated with an increased risk of infectious. With the ongoing coronavirus disease 2019 (COVID-19) pandemic, it is important to explore potential causal associations of sleep disturbance on COVID-19 susceptibility and hospitaliz...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-09-01
|
| Series: | Frontiers in Public Health |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2022.995664/full |
| _version_ | 1818016212029800448 |
|---|---|
| author | Liuqing Peng Jiarui Jing Jun Ma Simin He Xue Gao Tong Wang |
| author_facet | Liuqing Peng Jiarui Jing Jun Ma Simin He Xue Gao Tong Wang |
| author_sort | Liuqing Peng |
| collection | DOAJ |
| description | BackgroundSleep disturbance including insomnia and sleep duration is associated with an increased risk of infectious. With the ongoing coronavirus disease 2019 (COVID-19) pandemic, it is important to explore potential causal associations of sleep disturbance on COVID-19 susceptibility and hospitalization.MethodInsomnia and sleep duration were selected as exposure. Outcomes included susceptibility and hospitalization for COVID-19. Two sample mendelian randomization design was used to assess causality between sleep and COVID-19. Inverse variance weighted method was used as main analysis method to combine the ratio estimates for each instrumental variable to obtain the causal effect. Cochran's Q statistic was used to test for global heterogeneity. MR-Egger and weighting median estimator (WME) were used as sensitivity analysis to ensure the stability and reliability of the results. MR-Egger intercept term was used to test the mean pleiotropy. In addition, the direct effects of insomnia and sleep duration on COVID-19 susceptibility and hospitalization were estimated using multivariable mendelian randomization (MVMR).ResultsUnivariate MR provided no evidence of a causal associations of insomnia on COVID-19 susceptibility (OR = 1.10, 95% CI:0.95, 1.27; p = 0.21) and hospitalization (OR = 0.61, 95% CI:0.40, 0.92; p = 0.02); as does sleep duration (ORCOIVD − 19susceptibility = 0.93, 95% CI:0.86, 1.01; p = 0.07; ORCOIVD − 19hospitalization = 1.21, 95% CI: 0.99, 1.47; p = 0.08). MVMR results showed that insomnia may be a risk factor for increased susceptibility to COVID-19 (OR = 1.65, 95% CI: 1.34, 2.05; p <0.001); and sleep duration was also associated with increased COVID-19 susceptibility (OR = 1.31, 95% CI: 1.18, 1.46; p < 0.001).ConclusionInsomnia and extreme sleep duration may risk factors for increased COVID-19 susceptibility. Relieving insomnia and maintaining normal sleep duration may be powerful measures to reduce COVID-19 infections. |
| first_indexed | 2024-04-14T07:08:57Z |
| format | Article |
| id | doaj.art-3914452ca9064c04854cdf6b1c0f0231 |
| institution | Directory Open Access Journal |
| issn | 2296-2565 |
| language | English |
| last_indexed | 2024-04-14T07:08:57Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Public Health |
| spelling | doaj.art-3914452ca9064c04854cdf6b1c0f02312022-12-22T02:06:29ZengFrontiers Media S.A.Frontiers in Public Health2296-25652022-09-011010.3389/fpubh.2022.995664995664Insomnia and sleep duration on COVID-19 susceptibility and hospitalization: A Mendelian randomization studyLiuqing PengJiarui JingJun MaSimin HeXue GaoTong WangBackgroundSleep disturbance including insomnia and sleep duration is associated with an increased risk of infectious. With the ongoing coronavirus disease 2019 (COVID-19) pandemic, it is important to explore potential causal associations of sleep disturbance on COVID-19 susceptibility and hospitalization.MethodInsomnia and sleep duration were selected as exposure. Outcomes included susceptibility and hospitalization for COVID-19. Two sample mendelian randomization design was used to assess causality between sleep and COVID-19. Inverse variance weighted method was used as main analysis method to combine the ratio estimates for each instrumental variable to obtain the causal effect. Cochran's Q statistic was used to test for global heterogeneity. MR-Egger and weighting median estimator (WME) were used as sensitivity analysis to ensure the stability and reliability of the results. MR-Egger intercept term was used to test the mean pleiotropy. In addition, the direct effects of insomnia and sleep duration on COVID-19 susceptibility and hospitalization were estimated using multivariable mendelian randomization (MVMR).ResultsUnivariate MR provided no evidence of a causal associations of insomnia on COVID-19 susceptibility (OR = 1.10, 95% CI:0.95, 1.27; p = 0.21) and hospitalization (OR = 0.61, 95% CI:0.40, 0.92; p = 0.02); as does sleep duration (ORCOIVD − 19susceptibility = 0.93, 95% CI:0.86, 1.01; p = 0.07; ORCOIVD − 19hospitalization = 1.21, 95% CI: 0.99, 1.47; p = 0.08). MVMR results showed that insomnia may be a risk factor for increased susceptibility to COVID-19 (OR = 1.65, 95% CI: 1.34, 2.05; p <0.001); and sleep duration was also associated with increased COVID-19 susceptibility (OR = 1.31, 95% CI: 1.18, 1.46; p < 0.001).ConclusionInsomnia and extreme sleep duration may risk factors for increased COVID-19 susceptibility. Relieving insomnia and maintaining normal sleep duration may be powerful measures to reduce COVID-19 infections.https://www.frontiersin.org/articles/10.3389/fpubh.2022.995664/fullinsomniasleep durationCOVID-19Mendelian randomizationcausal inference |
| spellingShingle | Liuqing Peng Jiarui Jing Jun Ma Simin He Xue Gao Tong Wang Insomnia and sleep duration on COVID-19 susceptibility and hospitalization: A Mendelian randomization study Frontiers in Public Health insomnia sleep duration COVID-19 Mendelian randomization causal inference |
| title | Insomnia and sleep duration on COVID-19 susceptibility and hospitalization: A Mendelian randomization study |
| title_full | Insomnia and sleep duration on COVID-19 susceptibility and hospitalization: A Mendelian randomization study |
| title_fullStr | Insomnia and sleep duration on COVID-19 susceptibility and hospitalization: A Mendelian randomization study |
| title_full_unstemmed | Insomnia and sleep duration on COVID-19 susceptibility and hospitalization: A Mendelian randomization study |
| title_short | Insomnia and sleep duration on COVID-19 susceptibility and hospitalization: A Mendelian randomization study |
| title_sort | insomnia and sleep duration on covid 19 susceptibility and hospitalization a mendelian randomization study |
| topic | insomnia sleep duration COVID-19 Mendelian randomization causal inference |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2022.995664/full |
| work_keys_str_mv | AT liuqingpeng insomniaandsleepdurationoncovid19susceptibilityandhospitalizationamendelianrandomizationstudy AT jiaruijing insomniaandsleepdurationoncovid19susceptibilityandhospitalizationamendelianrandomizationstudy AT junma insomniaandsleepdurationoncovid19susceptibilityandhospitalizationamendelianrandomizationstudy AT siminhe insomniaandsleepdurationoncovid19susceptibilityandhospitalizationamendelianrandomizationstudy AT xuegao insomniaandsleepdurationoncovid19susceptibilityandhospitalizationamendelianrandomizationstudy AT tongwang insomniaandsleepdurationoncovid19susceptibilityandhospitalizationamendelianrandomizationstudy |