PKCζ-Mitogen-Activated Protein Kinase Signaling Mediates Crotalphine-Induced Antinociception

PKCζ-Mitogen-Activated Protein Kinase Signaling Mediates Crotalphine-Induced Antinociception

Crotalphine (CRP) is a structural analogue to a peptide that was first identified in the crude venom from the South American rattlesnake <i>Crotalus durissus terrificus</i>. This peptide induces a potent and long-lasting antinociceptive effect that is mediated by the activation of periph...

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Bibliographic Details
Main Authors: Bárbara G. de Freitas, Natália G. Hösch, Leandro M. Pereira, Tereza C. Barbosa, Gisele Picolo, Yara Cury, Vanessa O. Zambelli
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Toxins
Subjects:
analgesic peptide
protein kinase C
hyperalgesia
cell-signaling
Online Access:https://www.mdpi.com/2072-6651/13/12/912

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