Functionalized liposomes for targeted breast cancer drug delivery
Despite the exceptional progress in breast cancer pathogenesis, prognosis, diagnosis, and treatment strategies, it remains a prominent cause of female mortality worldwide. Additionally, although chemotherapies are effective, they are associated with critical limitations, most notably their lack of s...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2023-06-01
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| Series: | Bioactive Materials |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X22005230 |
| _version_ | 1797866081895841792 |
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| author | Janske Nel Kamil Elkhoury Émilie Velot Arnaud Bianchi Samir Acherar Grégory Francius Ali Tamayol Stéphanie Grandemange Elmira Arab-Tehrany |
| author_facet | Janske Nel Kamil Elkhoury Émilie Velot Arnaud Bianchi Samir Acherar Grégory Francius Ali Tamayol Stéphanie Grandemange Elmira Arab-Tehrany |
| author_sort | Janske Nel |
| collection | DOAJ |
| description | Despite the exceptional progress in breast cancer pathogenesis, prognosis, diagnosis, and treatment strategies, it remains a prominent cause of female mortality worldwide. Additionally, although chemotherapies are effective, they are associated with critical limitations, most notably their lack of specificity resulting in systemic toxicity and the eventual development of multi-drug resistance (MDR) cancer cells. Liposomes have proven to be an invaluable drug delivery system but of the multitudes of liposomal systems developed every year only a few have been approved for clinical use, none of which employ active targeting. In this review, we summarize the most recent strategies in development for actively targeted liposomal drug delivery systems for surface, transmembrane and internal cell receptors, enzymes, direct cell targeting and dual-targeting of breast cancer and breast cancer-associated cells, e.g., cancer stem cells, cells associated with the tumor microenvironment, etc. |
| first_indexed | 2024-04-09T23:18:20Z |
| format | Article |
| id | doaj.art-391498c7a3824dc88ce80e5c0325b6d8 |
| institution | Directory Open Access Journal |
| issn | 2452-199X |
| language | English |
| last_indexed | 2024-04-09T23:18:20Z |
| publishDate | 2023-06-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj.art-391498c7a3824dc88ce80e5c0325b6d82023-03-22T04:37:35ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2023-06-0124401437Functionalized liposomes for targeted breast cancer drug deliveryJanske Nel0Kamil Elkhoury1Émilie Velot2Arnaud Bianchi3Samir Acherar4Grégory Francius5Ali Tamayol6Stéphanie Grandemange7Elmira Arab-Tehrany8Université de Lorraine, LIBio, F-54000, Nancy, FranceLAAS-CNRS, F-31400, Toulouse, FranceUniversité de Lorraine, CNRS, IMoPA, F-54000, Nancy, FranceUniversité de Lorraine, CNRS, IMoPA, F-54000, Nancy, FranceUniversité de Lorraine, CNRS, LCPM, F-54000, Nancy, FranceUniversité de Lorraine, CNRS, LCPME, F-54000, Nancy, FranceDepartment of Biomedical Engineering, University of Connecticut Health Center, Farmington, CT, 06030, USAUniversité de Lorraine, CNRS, CRAN, F-54000, Nancy, France; Corresponding author.Université de Lorraine, LIBio, F-54000, Nancy, France; Corresponding author.Despite the exceptional progress in breast cancer pathogenesis, prognosis, diagnosis, and treatment strategies, it remains a prominent cause of female mortality worldwide. Additionally, although chemotherapies are effective, they are associated with critical limitations, most notably their lack of specificity resulting in systemic toxicity and the eventual development of multi-drug resistance (MDR) cancer cells. Liposomes have proven to be an invaluable drug delivery system but of the multitudes of liposomal systems developed every year only a few have been approved for clinical use, none of which employ active targeting. In this review, we summarize the most recent strategies in development for actively targeted liposomal drug delivery systems for surface, transmembrane and internal cell receptors, enzymes, direct cell targeting and dual-targeting of breast cancer and breast cancer-associated cells, e.g., cancer stem cells, cells associated with the tumor microenvironment, etc.http://www.sciencedirect.com/science/article/pii/S2452199X22005230LiposomesBreast cancerAnti-cancer agentsTargeted drug deliverySurface functionalizationReceptor-targeted drug delivery |
| spellingShingle | Janske Nel Kamil Elkhoury Émilie Velot Arnaud Bianchi Samir Acherar Grégory Francius Ali Tamayol Stéphanie Grandemange Elmira Arab-Tehrany Functionalized liposomes for targeted breast cancer drug delivery Bioactive Materials Liposomes Breast cancer Anti-cancer agents Targeted drug delivery Surface functionalization Receptor-targeted drug delivery |
| title | Functionalized liposomes for targeted breast cancer drug delivery |
| title_full | Functionalized liposomes for targeted breast cancer drug delivery |
| title_fullStr | Functionalized liposomes for targeted breast cancer drug delivery |
| title_full_unstemmed | Functionalized liposomes for targeted breast cancer drug delivery |
| title_short | Functionalized liposomes for targeted breast cancer drug delivery |
| title_sort | functionalized liposomes for targeted breast cancer drug delivery |
| topic | Liposomes Breast cancer Anti-cancer agents Targeted drug delivery Surface functionalization Receptor-targeted drug delivery |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X22005230 |
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