GM‐CSF signalling in Th17‐cell pathogenicity: The culprit in autoimmune uveitis promoted by sleep loss
Abstract Sleep loss (SL) is a health problem that affects autoimmune and inflammatory diseases. However, the relationship between SL, the immune system and autoimmune diseases remains unclear. This commentary summarizes and discusses the key findings of the study by Liu et al. published in Clinical...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-06-01
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| Series: | Clinical and Translational Discovery |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ctd2.209 |
| _version_ | 1797354931904053248 |
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| author | Chun Zhang Jing Xiao Fanwen Jiang Luzhong Fa Hui Jiang Lin Zhou Zhuping Xu |
| author_facet | Chun Zhang Jing Xiao Fanwen Jiang Luzhong Fa Hui Jiang Lin Zhou Zhuping Xu |
| author_sort | Chun Zhang |
| collection | DOAJ |
| description | Abstract Sleep loss (SL) is a health problem that affects autoimmune and inflammatory diseases. However, the relationship between SL, the immune system and autoimmune diseases remains unclear. This commentary summarizes and discusses the key findings of the study by Liu et al. published in Clinical and Translational Medicine. In this study, they analysed the effects of SL on autoimmune uveitis using mass cytometry, single‐cell RNA sequencing, and flow cytometry. They identified changes in the composition and function of human and mouse immune cells following SL that primarily involved effector CD4+ T cells and myeloid cells. Furthermore, they demonstrated that SL promoted Th17 differentiation, pathogenicity, and Interleukin‐23 (IL‐23)–Th17– granulocyte macrophage colony stimulating factor (GM‐CSF) feedback mechanism in autoimmunity. Finally, they attenuated SL‐induced EAU exacerbation using anti‐GM‐CSF treatment, providing a novel therapeutic approach for SL‐related autoimmune diseases. |
| first_indexed | 2024-03-08T13:56:57Z |
| format | Article |
| id | doaj.art-3914f2e0167e4f33a246cac578145421 |
| institution | Directory Open Access Journal |
| issn | 2768-0622 |
| language | English |
| last_indexed | 2024-03-08T13:56:57Z |
| publishDate | 2023-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Translational Discovery |
| spelling | doaj.art-3914f2e0167e4f33a246cac5781454212024-01-15T11:50:30ZengWileyClinical and Translational Discovery2768-06222023-06-0133n/an/a10.1002/ctd2.209GM‐CSF signalling in Th17‐cell pathogenicity: The culprit in autoimmune uveitis promoted by sleep lossChun Zhang0Jing Xiao1Fanwen Jiang2Luzhong Fa3Hui Jiang4Lin Zhou5Zhuping Xu6Department of Ophthalmology West China Hospital Sichuan University Chengdu ChinaDepartment of Ophthalmology West China Hospital Sichuan University Chengdu ChinaDepartment of Ophthalmology West China Hospital Sichuan University Chengdu ChinaDepartment of Ophthalmology West China Hospital Sichuan University Chengdu ChinaDepartment of Ophthalmology West China Hospital Sichuan University Chengdu ChinaDepartment of Ophthalmology West China Hospital Sichuan University Chengdu ChinaDepartment of Ophthalmology West China Hospital Sichuan University Chengdu ChinaAbstract Sleep loss (SL) is a health problem that affects autoimmune and inflammatory diseases. However, the relationship between SL, the immune system and autoimmune diseases remains unclear. This commentary summarizes and discusses the key findings of the study by Liu et al. published in Clinical and Translational Medicine. In this study, they analysed the effects of SL on autoimmune uveitis using mass cytometry, single‐cell RNA sequencing, and flow cytometry. They identified changes in the composition and function of human and mouse immune cells following SL that primarily involved effector CD4+ T cells and myeloid cells. Furthermore, they demonstrated that SL promoted Th17 differentiation, pathogenicity, and Interleukin‐23 (IL‐23)–Th17– granulocyte macrophage colony stimulating factor (GM‐CSF) feedback mechanism in autoimmunity. Finally, they attenuated SL‐induced EAU exacerbation using anti‐GM‐CSF treatment, providing a novel therapeutic approach for SL‐related autoimmune diseases.https://doi.org/10.1002/ctd2.209autoimmune uveitisGM‐CSFmass cytometrysingle‐cell RNA sequencingsleep lossTh17 cells |
| spellingShingle | Chun Zhang Jing Xiao Fanwen Jiang Luzhong Fa Hui Jiang Lin Zhou Zhuping Xu GM‐CSF signalling in Th17‐cell pathogenicity: The culprit in autoimmune uveitis promoted by sleep loss Clinical and Translational Discovery autoimmune uveitis GM‐CSF mass cytometry single‐cell RNA sequencing sleep loss Th17 cells |
| title | GM‐CSF signalling in Th17‐cell pathogenicity: The culprit in autoimmune uveitis promoted by sleep loss |
| title_full | GM‐CSF signalling in Th17‐cell pathogenicity: The culprit in autoimmune uveitis promoted by sleep loss |
| title_fullStr | GM‐CSF signalling in Th17‐cell pathogenicity: The culprit in autoimmune uveitis promoted by sleep loss |
| title_full_unstemmed | GM‐CSF signalling in Th17‐cell pathogenicity: The culprit in autoimmune uveitis promoted by sleep loss |
| title_short | GM‐CSF signalling in Th17‐cell pathogenicity: The culprit in autoimmune uveitis promoted by sleep loss |
| title_sort | gm csf signalling in th17 cell pathogenicity the culprit in autoimmune uveitis promoted by sleep loss |
| topic | autoimmune uveitis GM‐CSF mass cytometry single‐cell RNA sequencing sleep loss Th17 cells |
| url | https://doi.org/10.1002/ctd2.209 |
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