The Prevalence of Mild Cognitive Impairment in Diverse Geographical and Ethnocultural Regions: The COSMIC Collaboration.
BACKGROUND:Changes in criteria and differences in populations studied and methodology have produced a wide range of prevalence estimates for mild cognitive impairment (MCI). METHODS:Uniform criteria were applied to harmonized data from 11 studies from USA, Europe, Asia and Australia, and MCI prevale...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4634954?pdf=render |
| _version_ | 1811199898831290368 |
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| author | Perminder S Sachdev Darren M Lipnicki Nicole A Kochan John D Crawford Anbupalam Thalamuthu Gavin Andrews Carol Brayne Fiona E Matthews Blossom C M Stephan Richard B Lipton Mindy J Katz Karen Ritchie Isabelle Carrière Marie-Laure Ancelin Linda C W Lam Candy H Y Wong Ada W T Fung Antonio Guaita Roberta Vaccaro Annalisa Davin Mary Ganguli Hiroko Dodge Tiffany Hughes Kaarin J Anstey Nicolas Cherbuin Peter Butterworth Tze Pin Ng Qi Gao Simone Reppermund Henry Brodaty Nicole Schupf Jennifer Manly Yaakov Stern Antonio Lobo Raúl Lopez-Anton Javier Santabárbara Cohort Studies of Memory in an International Consortium (COSMIC) |
| author_facet | Perminder S Sachdev Darren M Lipnicki Nicole A Kochan John D Crawford Anbupalam Thalamuthu Gavin Andrews Carol Brayne Fiona E Matthews Blossom C M Stephan Richard B Lipton Mindy J Katz Karen Ritchie Isabelle Carrière Marie-Laure Ancelin Linda C W Lam Candy H Y Wong Ada W T Fung Antonio Guaita Roberta Vaccaro Annalisa Davin Mary Ganguli Hiroko Dodge Tiffany Hughes Kaarin J Anstey Nicolas Cherbuin Peter Butterworth Tze Pin Ng Qi Gao Simone Reppermund Henry Brodaty Nicole Schupf Jennifer Manly Yaakov Stern Antonio Lobo Raúl Lopez-Anton Javier Santabárbara Cohort Studies of Memory in an International Consortium (COSMIC) |
| author_sort | Perminder S Sachdev |
| collection | DOAJ |
| description | BACKGROUND:Changes in criteria and differences in populations studied and methodology have produced a wide range of prevalence estimates for mild cognitive impairment (MCI). METHODS:Uniform criteria were applied to harmonized data from 11 studies from USA, Europe, Asia and Australia, and MCI prevalence estimates determined using three separate definitions of cognitive impairment. RESULTS:The published range of MCI prevalence estimates was 5.0%-36.7%. This was reduced with all cognitive impairment definitions: performance in the bottom 6.681% (3.2%-10.8%); Clinical Dementia Rating of 0.5 (1.8%-14.9%); Mini-Mental State Examination score of 24-27 (2.1%-20.7%). Prevalences using the first definition were 5.9% overall, and increased with age (P < .001) but were unaffected by sex or the main races/ethnicities investigated (Whites and Chinese). Not completing high school increased the likelihood of MCI (P ≤ .01). CONCLUSION:Applying uniform criteria to harmonized data greatly reduced the variation in MCI prevalence internationally. |
| first_indexed | 2024-04-12T01:55:46Z |
| format | Article |
| id | doaj.art-3917a7cb73294d21ba36d5c5b96e7b2d |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-12T01:55:46Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-3917a7cb73294d21ba36d5c5b96e7b2d2022-12-22T03:52:49ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-011011e014238810.1371/journal.pone.0142388The Prevalence of Mild Cognitive Impairment in Diverse Geographical and Ethnocultural Regions: The COSMIC Collaboration.Perminder S SachdevDarren M LipnickiNicole A KochanJohn D CrawfordAnbupalam ThalamuthuGavin AndrewsCarol BrayneFiona E MatthewsBlossom C M StephanRichard B LiptonMindy J KatzKaren RitchieIsabelle CarrièreMarie-Laure AncelinLinda C W LamCandy H Y WongAda W T FungAntonio GuaitaRoberta VaccaroAnnalisa DavinMary GanguliHiroko DodgeTiffany HughesKaarin J AnsteyNicolas CherbuinPeter ButterworthTze Pin NgQi GaoSimone ReppermundHenry BrodatyNicole SchupfJennifer ManlyYaakov SternAntonio LoboRaúl Lopez-AntonJavier SantabárbaraCohort Studies of Memory in an International Consortium (COSMIC)BACKGROUND:Changes in criteria and differences in populations studied and methodology have produced a wide range of prevalence estimates for mild cognitive impairment (MCI). METHODS:Uniform criteria were applied to harmonized data from 11 studies from USA, Europe, Asia and Australia, and MCI prevalence estimates determined using three separate definitions of cognitive impairment. RESULTS:The published range of MCI prevalence estimates was 5.0%-36.7%. This was reduced with all cognitive impairment definitions: performance in the bottom 6.681% (3.2%-10.8%); Clinical Dementia Rating of 0.5 (1.8%-14.9%); Mini-Mental State Examination score of 24-27 (2.1%-20.7%). Prevalences using the first definition were 5.9% overall, and increased with age (P < .001) but were unaffected by sex or the main races/ethnicities investigated (Whites and Chinese). Not completing high school increased the likelihood of MCI (P ≤ .01). CONCLUSION:Applying uniform criteria to harmonized data greatly reduced the variation in MCI prevalence internationally.http://europepmc.org/articles/PMC4634954?pdf=render |
| spellingShingle | Perminder S Sachdev Darren M Lipnicki Nicole A Kochan John D Crawford Anbupalam Thalamuthu Gavin Andrews Carol Brayne Fiona E Matthews Blossom C M Stephan Richard B Lipton Mindy J Katz Karen Ritchie Isabelle Carrière Marie-Laure Ancelin Linda C W Lam Candy H Y Wong Ada W T Fung Antonio Guaita Roberta Vaccaro Annalisa Davin Mary Ganguli Hiroko Dodge Tiffany Hughes Kaarin J Anstey Nicolas Cherbuin Peter Butterworth Tze Pin Ng Qi Gao Simone Reppermund Henry Brodaty Nicole Schupf Jennifer Manly Yaakov Stern Antonio Lobo Raúl Lopez-Anton Javier Santabárbara Cohort Studies of Memory in an International Consortium (COSMIC) The Prevalence of Mild Cognitive Impairment in Diverse Geographical and Ethnocultural Regions: The COSMIC Collaboration. PLoS ONE |
| title | The Prevalence of Mild Cognitive Impairment in Diverse Geographical and Ethnocultural Regions: The COSMIC Collaboration. |
| title_full | The Prevalence of Mild Cognitive Impairment in Diverse Geographical and Ethnocultural Regions: The COSMIC Collaboration. |
| title_fullStr | The Prevalence of Mild Cognitive Impairment in Diverse Geographical and Ethnocultural Regions: The COSMIC Collaboration. |
| title_full_unstemmed | The Prevalence of Mild Cognitive Impairment in Diverse Geographical and Ethnocultural Regions: The COSMIC Collaboration. |
| title_short | The Prevalence of Mild Cognitive Impairment in Diverse Geographical and Ethnocultural Regions: The COSMIC Collaboration. |
| title_sort | prevalence of mild cognitive impairment in diverse geographical and ethnocultural regions the cosmic collaboration |
| url | http://europepmc.org/articles/PMC4634954?pdf=render |
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