Recent scientific advances in leiomyoma (uterine fibroids) research facilitates better understanding and management [v1; ref status: indexed, http://f1000r.es/54a]
Uterine leiomyomas (fibroids) are the most prevalent medical problem of the female reproductive tract, but there are few non-surgical treatment options. Although many advances in the understanding of the molecular components of these tumors have occurred over the past five years, an effective pharma...
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| Format: | Article |
| Language: | English |
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F1000 Research Ltd
2015-07-01
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| Series: | F1000Research |
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| Online Access: | http://f1000research.com/articles/4-183/v1 |
| _version_ | 1819229249858437120 |
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| author | Darlene K. Taylor Kristine Holthouser James H. Segars Phyllis C. Leppert |
| author_facet | Darlene K. Taylor Kristine Holthouser James H. Segars Phyllis C. Leppert |
| author_sort | Darlene K. Taylor |
| collection | DOAJ |
| description | Uterine leiomyomas (fibroids) are the most prevalent medical problem of the female reproductive tract, but there are few non-surgical treatment options. Although many advances in the understanding of the molecular components of these tumors have occurred over the past five years, an effective pharmaceutical approach remains elusive. Further, there is currently no clinical method to distinguish a benign uterine leiomyoma from a malignant leiomyosarcoma prior to treatment, a pressing need given concerns about the use of the power morcellator for minimally invasive surgery. This paper reviews current studies regarding the molecular biology of uterine fibroids, discusses non-surgical approaches and suggests new cutting-edge therapeutic and diagnostic approaches. |
| first_indexed | 2024-12-23T11:10:11Z |
| format | Article |
| id | doaj.art-39193b95a1ce4453ae5bdc8a9d59fe40 |
| institution | Directory Open Access Journal |
| issn | 2046-1402 |
| language | English |
| last_indexed | 2024-12-23T11:10:11Z |
| publishDate | 2015-07-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | F1000Research |
| spelling | doaj.art-39193b95a1ce4453ae5bdc8a9d59fe402022-12-21T17:49:22ZengF1000 Research LtdF1000Research2046-14022015-07-01410.12688/f1000research.6189.16634Recent scientific advances in leiomyoma (uterine fibroids) research facilitates better understanding and management [v1; ref status: indexed, http://f1000r.es/54a]Darlene K. Taylor0Kristine Holthouser1James H. Segars2Phyllis C. Leppert3Department of Chemistry, North Carolina Central University, Durham, NC, 27707, USADepartment of Obstetrics and Gynecology, University of Louisville, Louisville, KY, USADepartment of Gynecology and Obstetrics, Johns Hopkins School of Medicine, Baltimore, MD, 21205, USADepartment of Obstetrics and Gynecology, Duke University School of Medicine, Durham, NC, 27710, USAUterine leiomyomas (fibroids) are the most prevalent medical problem of the female reproductive tract, but there are few non-surgical treatment options. Although many advances in the understanding of the molecular components of these tumors have occurred over the past five years, an effective pharmaceutical approach remains elusive. Further, there is currently no clinical method to distinguish a benign uterine leiomyoma from a malignant leiomyosarcoma prior to treatment, a pressing need given concerns about the use of the power morcellator for minimally invasive surgery. This paper reviews current studies regarding the molecular biology of uterine fibroids, discusses non-surgical approaches and suggests new cutting-edge therapeutic and diagnostic approaches.http://f1000research.com/articles/4-183/v1Female Fertility RegulationGenitourinary CancersGenito-Urinary & Reproductive PharmacologyMenstrual Abnormalities & Abnormal Uterine BleedingReproductive Physiology |
| spellingShingle | Darlene K. Taylor Kristine Holthouser James H. Segars Phyllis C. Leppert Recent scientific advances in leiomyoma (uterine fibroids) research facilitates better understanding and management [v1; ref status: indexed, http://f1000r.es/54a] F1000Research Female Fertility Regulation Genitourinary Cancers Genito-Urinary & Reproductive Pharmacology Menstrual Abnormalities & Abnormal Uterine Bleeding Reproductive Physiology |
| title | Recent scientific advances in leiomyoma (uterine fibroids) research facilitates better understanding and management [v1; ref status: indexed, http://f1000r.es/54a] |
| title_full | Recent scientific advances in leiomyoma (uterine fibroids) research facilitates better understanding and management [v1; ref status: indexed, http://f1000r.es/54a] |
| title_fullStr | Recent scientific advances in leiomyoma (uterine fibroids) research facilitates better understanding and management [v1; ref status: indexed, http://f1000r.es/54a] |
| title_full_unstemmed | Recent scientific advances in leiomyoma (uterine fibroids) research facilitates better understanding and management [v1; ref status: indexed, http://f1000r.es/54a] |
| title_short | Recent scientific advances in leiomyoma (uterine fibroids) research facilitates better understanding and management [v1; ref status: indexed, http://f1000r.es/54a] |
| title_sort | recent scientific advances in leiomyoma uterine fibroids research facilitates better understanding and management v1 ref status indexed http f1000r es 54a |
| topic | Female Fertility Regulation Genitourinary Cancers Genito-Urinary & Reproductive Pharmacology Menstrual Abnormalities & Abnormal Uterine Bleeding Reproductive Physiology |
| url | http://f1000research.com/articles/4-183/v1 |
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