Traditional Chinese medicine for the treatment of immune-related nephropathy: A review
Immune-related nephropathy (IRN) refers to immune-response-mediated glomerulonephritis and is the main cause of end-stage renal failure. The pathogenesis of IRN is not fully understood; therefore, treatment is challenging. Traditional Chinese medicines (TCMs) have potent clinical effects in the trea...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Acta Pharmaceutica Sinica B |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211383523004288 |
| _version_ | 1797365568573014016 |
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| author | Pu Jiang Changliang Yao De-an Guo |
| author_facet | Pu Jiang Changliang Yao De-an Guo |
| author_sort | Pu Jiang |
| collection | DOAJ |
| description | Immune-related nephropathy (IRN) refers to immune-response-mediated glomerulonephritis and is the main cause of end-stage renal failure. The pathogenesis of IRN is not fully understood; therefore, treatment is challenging. Traditional Chinese medicines (TCMs) have potent clinical effects in the treatment of the IRN conditions immunoglobulin A nephropathy, lupus nephropathy, and diabetic nephropathy. The underlying mechanisms mainly include its inhibition of inflammation; improvements to renal interstitial fibrosis, oxidative stress, autophagy, apoptosis; and regulation of immunity. In this review, we summarize the clinical symptoms of the three IRN subtypes and the use of TCM prescriptions, herbs, and bioactive compounds in treating IRN, as well as the potential mechanisms, intending to provide a reference for the future study of TCM as IRN treatments. |
| first_indexed | 2024-03-08T16:50:51Z |
| format | Article |
| id | doaj.art-3919bb87106a444eb826925ab9397a02 |
| institution | Directory Open Access Journal |
| issn | 2211-3835 |
| language | English |
| last_indexed | 2024-03-08T16:50:51Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Acta Pharmaceutica Sinica B |
| spelling | doaj.art-3919bb87106a444eb826925ab9397a022024-01-05T04:24:48ZengElsevierActa Pharmaceutica Sinica B2211-38352024-01-011413866Traditional Chinese medicine for the treatment of immune-related nephropathy: A reviewPu Jiang0Changliang Yao1De-an Guo2School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China; Shanghai Research Center for Modernization of Traditional Chinese Medicine, National Engineering Research Center of TCM Standardization Technology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, ChinaShanghai Research Center for Modernization of Traditional Chinese Medicine, National Engineering Research Center of TCM Standardization Technology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, ChinaSchool of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China; Shanghai Research Center for Modernization of Traditional Chinese Medicine, National Engineering Research Center of TCM Standardization Technology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; Corresponding author.Immune-related nephropathy (IRN) refers to immune-response-mediated glomerulonephritis and is the main cause of end-stage renal failure. The pathogenesis of IRN is not fully understood; therefore, treatment is challenging. Traditional Chinese medicines (TCMs) have potent clinical effects in the treatment of the IRN conditions immunoglobulin A nephropathy, lupus nephropathy, and diabetic nephropathy. The underlying mechanisms mainly include its inhibition of inflammation; improvements to renal interstitial fibrosis, oxidative stress, autophagy, apoptosis; and regulation of immunity. In this review, we summarize the clinical symptoms of the three IRN subtypes and the use of TCM prescriptions, herbs, and bioactive compounds in treating IRN, as well as the potential mechanisms, intending to provide a reference for the future study of TCM as IRN treatments.http://www.sciencedirect.com/science/article/pii/S2211383523004288IgA nephropathyDiabetic nephropathyLupus nephritisTraditional Chinese medicineImmunityPathogenesis |
| spellingShingle | Pu Jiang Changliang Yao De-an Guo Traditional Chinese medicine for the treatment of immune-related nephropathy: A review Acta Pharmaceutica Sinica B IgA nephropathy Diabetic nephropathy Lupus nephritis Traditional Chinese medicine Immunity Pathogenesis |
| title | Traditional Chinese medicine for the treatment of immune-related nephropathy: A review |
| title_full | Traditional Chinese medicine for the treatment of immune-related nephropathy: A review |
| title_fullStr | Traditional Chinese medicine for the treatment of immune-related nephropathy: A review |
| title_full_unstemmed | Traditional Chinese medicine for the treatment of immune-related nephropathy: A review |
| title_short | Traditional Chinese medicine for the treatment of immune-related nephropathy: A review |
| title_sort | traditional chinese medicine for the treatment of immune related nephropathy a review |
| topic | IgA nephropathy Diabetic nephropathy Lupus nephritis Traditional Chinese medicine Immunity Pathogenesis |
| url | http://www.sciencedirect.com/science/article/pii/S2211383523004288 |
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