Three Signs to Help Detect Sjögren’s Syndrome: Incidental Findings on Magnetic Resonance Imaging and Computed Tomography
This study aimed to retrospectively investigate the prevalence of Sjögren’s syndrome (SS) among patients with ranulas, parotid cysts, or parotid calcifications; identify the characteristic magnetic resonance imaging (MRI) or computed tomography (CT) findings of the lesions associated with SS; and co...
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-10-01
|
| Series: | Journal of Clinical Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0383/12/20/6487 |
| _version_ | 1797573447161741312 |
|---|---|
| author | Yukinori Takagi Ikuo Katayama Sato Eida Miho Sasaki Toshimasa Shimizu Shuntaro Sato Kunio Hashimoto Hiroki Mori Mitsunobu Otsuru Masahiro Umeda Yoshihiko Kumai Ryo Toya Atsushi Kawakami Misa Sumi |
| author_facet | Yukinori Takagi Ikuo Katayama Sato Eida Miho Sasaki Toshimasa Shimizu Shuntaro Sato Kunio Hashimoto Hiroki Mori Mitsunobu Otsuru Masahiro Umeda Yoshihiko Kumai Ryo Toya Atsushi Kawakami Misa Sumi |
| author_sort | Yukinori Takagi |
| collection | DOAJ |
| description | This study aimed to retrospectively investigate the prevalence of Sjögren’s syndrome (SS) among patients with ranulas, parotid cysts, or parotid calcifications; identify the characteristic magnetic resonance imaging (MRI) or computed tomography (CT) findings of the lesions associated with SS; and compare the SS disease stages among SS patients with the three lesion types. A total of 228 patients with the lesions were classified into SS, possible SS, and non-SS groups. The prevalence of SS among patients with ranulas, parotid cysts, or parotid calcifications was 16%, 24%, and 40%, and the rates of either SS or possible SS were 25%, 41%, and 64%, respectively. SS was associated with (i) ranulas: ≤17 mm; (ii) parotid cysts: bilateral and multiple; and (iii) parotid calcifications: in females, bilateral, multiple, parenchymal, and no coexisting calcifications in other tissues. SS patients with ranulas were significantly younger and had lower submandibular gland stage scores on MRI/CT than those with other lesions. Additionally, in 58% and 15% of SS patients with ranulas and parotid calcifications, respectively, detection of the lesions led to the diagnosis of primary SS. Therefore, recognizing the prevalence of SS among patients with these lesions and the findings associated with SS can help detect undiagnosed SS. |
| first_indexed | 2024-03-10T21:09:40Z |
| format | Article |
| id | doaj.art-391ae93a35234efc8a8addf066ed42cc |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T21:09:40Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-391ae93a35234efc8a8addf066ed42cc2023-11-19T16:51:53ZengMDPI AGJournal of Clinical Medicine2077-03832023-10-011220648710.3390/jcm12206487Three Signs to Help Detect Sjögren’s Syndrome: Incidental Findings on Magnetic Resonance Imaging and Computed TomographyYukinori Takagi0Ikuo Katayama1Sato Eida2Miho Sasaki3Toshimasa Shimizu4Shuntaro Sato5Kunio Hashimoto6Hiroki Mori7Mitsunobu Otsuru8Masahiro Umeda9Yoshihiko Kumai10Ryo Toya11Atsushi Kawakami12Misa Sumi13Department of Radiology and Biomedical Informatics, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki 852-8588, JapanDepartment of Radiology and Biomedical Informatics, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki 852-8588, JapanDepartment of Radiology and Biomedical Informatics, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki 852-8588, JapanDepartment of Radiology and Biomedical Informatics, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki 852-8588, JapanDepartment of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki 852-8501, JapanClinical Research Center, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki 852-8501, JapanDepartment of Pediatrics, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki 852-8501, JapanDepartment of Radiology and Biomedical Informatics, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki 852-8588, JapanDepartment of Clinical Oral Oncology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki 852-8588, JapanDepartment of Clinical Oral Oncology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki 852-8588, JapanDepartment of Otolaryngology-Head and Neck Surgery, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki 852-8501, JapanDepartment of Radiological Sciences, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki 852-8501, JapanDepartment of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki 852-8501, JapanDepartment of Radiology and Biomedical Informatics, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki 852-8588, JapanThis study aimed to retrospectively investigate the prevalence of Sjögren’s syndrome (SS) among patients with ranulas, parotid cysts, or parotid calcifications; identify the characteristic magnetic resonance imaging (MRI) or computed tomography (CT) findings of the lesions associated with SS; and compare the SS disease stages among SS patients with the three lesion types. A total of 228 patients with the lesions were classified into SS, possible SS, and non-SS groups. The prevalence of SS among patients with ranulas, parotid cysts, or parotid calcifications was 16%, 24%, and 40%, and the rates of either SS or possible SS were 25%, 41%, and 64%, respectively. SS was associated with (i) ranulas: ≤17 mm; (ii) parotid cysts: bilateral and multiple; and (iii) parotid calcifications: in females, bilateral, multiple, parenchymal, and no coexisting calcifications in other tissues. SS patients with ranulas were significantly younger and had lower submandibular gland stage scores on MRI/CT than those with other lesions. Additionally, in 58% and 15% of SS patients with ranulas and parotid calcifications, respectively, detection of the lesions led to the diagnosis of primary SS. Therefore, recognizing the prevalence of SS among patients with these lesions and the findings associated with SS can help detect undiagnosed SS.https://www.mdpi.com/2077-0383/12/20/6487Sjögren’s syndromesalivary glandmagnetic resonance imagingcomputed tomographyranulaparotid cyst |
| spellingShingle | Yukinori Takagi Ikuo Katayama Sato Eida Miho Sasaki Toshimasa Shimizu Shuntaro Sato Kunio Hashimoto Hiroki Mori Mitsunobu Otsuru Masahiro Umeda Yoshihiko Kumai Ryo Toya Atsushi Kawakami Misa Sumi Three Signs to Help Detect Sjögren’s Syndrome: Incidental Findings on Magnetic Resonance Imaging and Computed Tomography Journal of Clinical Medicine Sjögren’s syndrome salivary gland magnetic resonance imaging computed tomography ranula parotid cyst |
| title | Three Signs to Help Detect Sjögren’s Syndrome: Incidental Findings on Magnetic Resonance Imaging and Computed Tomography |
| title_full | Three Signs to Help Detect Sjögren’s Syndrome: Incidental Findings on Magnetic Resonance Imaging and Computed Tomography |
| title_fullStr | Three Signs to Help Detect Sjögren’s Syndrome: Incidental Findings on Magnetic Resonance Imaging and Computed Tomography |
| title_full_unstemmed | Three Signs to Help Detect Sjögren’s Syndrome: Incidental Findings on Magnetic Resonance Imaging and Computed Tomography |
| title_short | Three Signs to Help Detect Sjögren’s Syndrome: Incidental Findings on Magnetic Resonance Imaging and Computed Tomography |
| title_sort | three signs to help detect sjogren s syndrome incidental findings on magnetic resonance imaging and computed tomography |
| topic | Sjögren’s syndrome salivary gland magnetic resonance imaging computed tomography ranula parotid cyst |
| url | https://www.mdpi.com/2077-0383/12/20/6487 |
| work_keys_str_mv | AT yukinoritakagi threesignstohelpdetectsjogrenssyndromeincidentalfindingsonmagneticresonanceimagingandcomputedtomography AT ikuokatayama threesignstohelpdetectsjogrenssyndromeincidentalfindingsonmagneticresonanceimagingandcomputedtomography AT satoeida threesignstohelpdetectsjogrenssyndromeincidentalfindingsonmagneticresonanceimagingandcomputedtomography AT mihosasaki threesignstohelpdetectsjogrenssyndromeincidentalfindingsonmagneticresonanceimagingandcomputedtomography AT toshimasashimizu threesignstohelpdetectsjogrenssyndromeincidentalfindingsonmagneticresonanceimagingandcomputedtomography AT shuntarosato threesignstohelpdetectsjogrenssyndromeincidentalfindingsonmagneticresonanceimagingandcomputedtomography AT kuniohashimoto threesignstohelpdetectsjogrenssyndromeincidentalfindingsonmagneticresonanceimagingandcomputedtomography AT hirokimori threesignstohelpdetectsjogrenssyndromeincidentalfindingsonmagneticresonanceimagingandcomputedtomography AT mitsunobuotsuru threesignstohelpdetectsjogrenssyndromeincidentalfindingsonmagneticresonanceimagingandcomputedtomography AT masahiroumeda threesignstohelpdetectsjogrenssyndromeincidentalfindingsonmagneticresonanceimagingandcomputedtomography AT yoshihikokumai threesignstohelpdetectsjogrenssyndromeincidentalfindingsonmagneticresonanceimagingandcomputedtomography AT ryotoya threesignstohelpdetectsjogrenssyndromeincidentalfindingsonmagneticresonanceimagingandcomputedtomography AT atsushikawakami threesignstohelpdetectsjogrenssyndromeincidentalfindingsonmagneticresonanceimagingandcomputedtomography AT misasumi threesignstohelpdetectsjogrenssyndromeincidentalfindingsonmagneticresonanceimagingandcomputedtomography |