Paracetamol overdosing with 6500 mg single dose: Case report
Introduction: Paracetamol is available as a fixed dose combination with many non-steroidal anti-inflammatory drugs (NSAIDs) such as Ibuprofen, Diclofenac, Mefenamic acid, Aceclofenac etc. On the other hand, it is also considered as the most common cause of overdosing and poisoning. Paracetamol can b...
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| Format: | Article |
| Language: | English |
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Srpsko lekarsko drustvo
2022-01-01
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| Series: | Hospital Pharmacology |
| Subjects: | |
| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/2334-9492/2022/2334-94922202170M.pdf |
| _version_ | 1798041449874325504 |
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| author | Murthy Shiva N. Kumar Anil H. |
| author_facet | Murthy Shiva N. Kumar Anil H. |
| author_sort | Murthy Shiva N. |
| collection | DOAJ |
| description | Introduction: Paracetamol is available as a fixed dose combination with many non-steroidal anti-inflammatory drugs (NSAIDs) such as Ibuprofen, Diclofenac, Mefenamic acid, Aceclofenac etc. On the other hand, it is also considered as the most common cause of overdosing and poisoning. Paracetamol can be purchased both by prescription or as an OTC medicine. Case report: This paper represents a case of a male, age 27, vegetarian, who does regular exercise, alcoholic, who self-overdosed with 6500 mg (~10 tablets of 650 mg each) of Paracetamol with suicidal intention. An attempt has been made to discuss the effects of Paracetamol on liver, kidney and other organs function through hematology, biochemistry, urine investigations done within 24 hours and day 7 after overdosing. Results of additional investigations such as liver function tests done on day 4 and day 5, X-ray chest, ultrasound scan of the abdomen and ECG done on day 1 were also included for discussion. Liver parameters were checked for presence of Drug Induced Liver Injury (DILI) using an algorithm published by Pineda S L et al. Conclusion: Results of this case analysis suggested the presence of mild DILI with a single dose of 6500 mg Paracetamol. We recommend further studies using algorithm of Pineda S L et al to assess the minimum doses that are expected to cause clinically significant DILI and recommend policies to drug regulators of the country to restrict the maximum number of doses that can be sold to the general public on OTC basis. |
| first_indexed | 2024-04-11T22:21:42Z |
| format | Article |
| id | doaj.art-391c2ca8e4dc4d2287f723b7b74439cf |
| institution | Directory Open Access Journal |
| issn | 2334-9492 |
| language | English |
| last_indexed | 2024-04-11T22:21:42Z |
| publishDate | 2022-01-01 |
| publisher | Srpsko lekarsko drustvo |
| record_format | Article |
| series | Hospital Pharmacology |
| spelling | doaj.art-391c2ca8e4dc4d2287f723b7b74439cf2022-12-22T04:00:04ZengSrpsko lekarsko drustvoHospital Pharmacology2334-94922022-01-01921170117510.5937/hpimj2202170M2334-94922202170MParacetamol overdosing with 6500 mg single dose: Case reportMurthy Shiva N.0Kumar Anil H.1Dayanada Sagar University, Faculty of Pharmacology, Dr Chandramma Dayananda Sagar Institute of Medical Education and Research, Karnataka, IndiaDayanada Sagar University, Faculty of Internal Medicine, Dr Chandramma Dayananda Sagar Institute of Medical Education and Research, Karnataka, IndiaIntroduction: Paracetamol is available as a fixed dose combination with many non-steroidal anti-inflammatory drugs (NSAIDs) such as Ibuprofen, Diclofenac, Mefenamic acid, Aceclofenac etc. On the other hand, it is also considered as the most common cause of overdosing and poisoning. Paracetamol can be purchased both by prescription or as an OTC medicine. Case report: This paper represents a case of a male, age 27, vegetarian, who does regular exercise, alcoholic, who self-overdosed with 6500 mg (~10 tablets of 650 mg each) of Paracetamol with suicidal intention. An attempt has been made to discuss the effects of Paracetamol on liver, kidney and other organs function through hematology, biochemistry, urine investigations done within 24 hours and day 7 after overdosing. Results of additional investigations such as liver function tests done on day 4 and day 5, X-ray chest, ultrasound scan of the abdomen and ECG done on day 1 were also included for discussion. Liver parameters were checked for presence of Drug Induced Liver Injury (DILI) using an algorithm published by Pineda S L et al. Conclusion: Results of this case analysis suggested the presence of mild DILI with a single dose of 6500 mg Paracetamol. We recommend further studies using algorithm of Pineda S L et al to assess the minimum doses that are expected to cause clinically significant DILI and recommend policies to drug regulators of the country to restrict the maximum number of doses that can be sold to the general public on OTC basis.https://scindeks-clanci.ceon.rs/data/pdf/2334-9492/2022/2334-94922202170M.pdfparacetamol overdosingdrug induced liver injuryotc medication restriction |
| spellingShingle | Murthy Shiva N. Kumar Anil H. Paracetamol overdosing with 6500 mg single dose: Case report Hospital Pharmacology paracetamol overdosing drug induced liver injury otc medication restriction |
| title | Paracetamol overdosing with 6500 mg single dose: Case report |
| title_full | Paracetamol overdosing with 6500 mg single dose: Case report |
| title_fullStr | Paracetamol overdosing with 6500 mg single dose: Case report |
| title_full_unstemmed | Paracetamol overdosing with 6500 mg single dose: Case report |
| title_short | Paracetamol overdosing with 6500 mg single dose: Case report |
| title_sort | paracetamol overdosing with 6500 mg single dose case report |
| topic | paracetamol overdosing drug induced liver injury otc medication restriction |
| url | https://scindeks-clanci.ceon.rs/data/pdf/2334-9492/2022/2334-94922202170M.pdf |
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