Research Progress on Food Derived Blood Glucose Regulating Peptides
Diabetes mellitus has become one of the most serious chronic diseases all over the world, which need to be to prevented, intervened, regulated by innovative means. Food derived small peptides can regulate blood glucose by acting with receptors, enzymes, biological molecules and glucose transporters....
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| Format: | Article |
| Language: | zho |
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The editorial department of Science and Technology of Food Industry
2023-11-01
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| Series: | Shipin gongye ke-ji |
| Subjects: | |
| Online Access: | http://www.spgykj.com/cn/article/doi/10.13386/j.issn1002-0306.2023010077 |
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| author | Jingjing HUANG Yingqin ZHOU Xiufeng CHENG Zhang LUO Zhendong LIU Ningning XIE |
| author_facet | Jingjing HUANG Yingqin ZHOU Xiufeng CHENG Zhang LUO Zhendong LIU Ningning XIE |
| author_sort | Jingjing HUANG |
| collection | DOAJ |
| description | Diabetes mellitus has become one of the most serious chronic diseases all over the world, which need to be to prevented, intervened, regulated by innovative means. Food derived small peptides can regulate blood glucose by acting with receptors, enzymes, biological molecules and glucose transporters. They show high tissue affinities, significant specificities, with low side effects, which are promising strategies for diabetes mellitus. This survey summarizes the mechanisms, food protein sources, preparation and activity evaluation procedures, structure-activity relationships and challenges during commercial development of food derived blood glucose regulating peptides. Specifically, it includes the sequence characteristics of DPP-IV inhibitory peptide, α-glucosidase inhibitory peptides and α-amylase inhibitory peptides. Besides, the active sites are also discussed from different perspectives of sequence alignment: bioinformatics technologies such as in silico analysis, molecular structure alignment/docking, and quantitative structure activity relationship analysis. It may provide ideas for future research: a. Exploring the mechanism from the aspect of cell pathways and metabonomic to improve in vivo efficacy. b. Combining cell/animal experiments with clinical trials to evaluate digestive stability, bioavailability and safety. c. Innovative carriers to improve the solubility, stability and permeability of peptides. Supports for promoting the industrial application of diabetes functional foods are expected. |
| first_indexed | 2024-03-11T15:59:41Z |
| format | Article |
| id | doaj.art-391c5367f6964535aa6733e0b09d2c40 |
| institution | Directory Open Access Journal |
| issn | 1002-0306 |
| language | zho |
| last_indexed | 2024-03-11T15:59:41Z |
| publishDate | 2023-11-01 |
| publisher | The editorial department of Science and Technology of Food Industry |
| record_format | Article |
| series | Shipin gongye ke-ji |
| spelling | doaj.art-391c5367f6964535aa6733e0b09d2c402023-10-25T07:38:40ZzhoThe editorial department of Science and Technology of Food IndustryShipin gongye ke-ji1002-03062023-11-01442143144110.13386/j.issn1002-0306.20230100772023010077-21Research Progress on Food Derived Blood Glucose Regulating PeptidesJingjing HUANG0Yingqin ZHOU1Xiufeng CHENG2Zhang LUO3Zhendong LIU4Ningning XIE5Institute of Agro-product Science and Technology, Anhui Academy of Agricultural Sciences, Hefei 230001, ChinaInstitute of Agro-product Science and Technology, Anhui Academy of Agricultural Sciences, Hefei 230001, ChinaCollege of Food Science, Tibet Agriculture and Animal Husbandry University, Nyingchi 860000, ChinaCollege of Food Science, Tibet Agriculture and Animal Husbandry University, Nyingchi 860000, ChinaCollege of Food Science, Tibet Agriculture and Animal Husbandry University, Nyingchi 860000, ChinaInstitute of Agro-product Science and Technology, Anhui Academy of Agricultural Sciences, Hefei 230001, ChinaDiabetes mellitus has become one of the most serious chronic diseases all over the world, which need to be to prevented, intervened, regulated by innovative means. Food derived small peptides can regulate blood glucose by acting with receptors, enzymes, biological molecules and glucose transporters. They show high tissue affinities, significant specificities, with low side effects, which are promising strategies for diabetes mellitus. This survey summarizes the mechanisms, food protein sources, preparation and activity evaluation procedures, structure-activity relationships and challenges during commercial development of food derived blood glucose regulating peptides. Specifically, it includes the sequence characteristics of DPP-IV inhibitory peptide, α-glucosidase inhibitory peptides and α-amylase inhibitory peptides. Besides, the active sites are also discussed from different perspectives of sequence alignment: bioinformatics technologies such as in silico analysis, molecular structure alignment/docking, and quantitative structure activity relationship analysis. It may provide ideas for future research: a. Exploring the mechanism from the aspect of cell pathways and metabonomic to improve in vivo efficacy. b. Combining cell/animal experiments with clinical trials to evaluate digestive stability, bioavailability and safety. c. Innovative carriers to improve the solubility, stability and permeability of peptides. Supports for promoting the industrial application of diabetes functional foods are expected.http://www.spgykj.com/cn/article/doi/10.13386/j.issn1002-0306.2023010077food derived bioactive peptidesblood glucose regulationpeptide sequencesstructure-activity relationshipsbioinformatics |
| spellingShingle | Jingjing HUANG Yingqin ZHOU Xiufeng CHENG Zhang LUO Zhendong LIU Ningning XIE Research Progress on Food Derived Blood Glucose Regulating Peptides Shipin gongye ke-ji food derived bioactive peptides blood glucose regulation peptide sequences structure-activity relationships bioinformatics |
| title | Research Progress on Food Derived Blood Glucose Regulating Peptides |
| title_full | Research Progress on Food Derived Blood Glucose Regulating Peptides |
| title_fullStr | Research Progress on Food Derived Blood Glucose Regulating Peptides |
| title_full_unstemmed | Research Progress on Food Derived Blood Glucose Regulating Peptides |
| title_short | Research Progress on Food Derived Blood Glucose Regulating Peptides |
| title_sort | research progress on food derived blood glucose regulating peptides |
| topic | food derived bioactive peptides blood glucose regulation peptide sequences structure-activity relationships bioinformatics |
| url | http://www.spgykj.com/cn/article/doi/10.13386/j.issn1002-0306.2023010077 |
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