Can precancerous stem cells be risk markers for malignant transformation in the oral mucosa?
Abstract Accurate assessment of the carcinogenic potential of oral mucosal diseases can significantly reduce the prevalence of oral cancer. We speculate that precancerous stem cells (pCSCs) arise during the evolution of carcinomas based on long-term experimental findings, published literature, and t...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-04-01
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| Series: | Cellular & Molecular Biology Letters |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s11658-023-00441-0 |
| _version_ | 1797849955265675264 |
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| author | Shan Wang Liu Ying Shu-Yi Yu Jie Bai Chunbo Hao |
| author_facet | Shan Wang Liu Ying Shu-Yi Yu Jie Bai Chunbo Hao |
| author_sort | Shan Wang |
| collection | DOAJ |
| description | Abstract Accurate assessment of the carcinogenic potential of oral mucosal diseases can significantly reduce the prevalence of oral cancer. We speculate that precancerous stem cells (pCSCs) arise during the evolution of carcinomas based on long-term experimental findings, published literature, and the cancer stem cell (CSC) theory, wherein pCSCs exist in precancerous lesions and have characteristics of both CSCs and normal stem cells. This apparently contradictory feature may be the foundation of the reversible transformation of precancerous lesions. Predicting malignant transformation in potentially malignant oral illnesses would allow for focused treatment, prognosis, and secondary prevention. Currently available clinical assays for chromosomal instability and DNA aneuploidy have several deficiencies. We hope that our study will increase attention to pCSC research and lead to the development of novel strategies for the prevention and treatment of oral cancer by identifying pCSC markers. Graphical Abstract |
| first_indexed | 2024-04-09T18:52:34Z |
| format | Article |
| id | doaj.art-391f661aee8b4609a66eabd6c3af9681 |
| institution | Directory Open Access Journal |
| issn | 1689-1392 |
| language | English |
| last_indexed | 2024-04-09T18:52:34Z |
| publishDate | 2023-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Cellular & Molecular Biology Letters |
| spelling | doaj.art-391f661aee8b4609a66eabd6c3af96812023-04-09T11:22:17ZengBMCCellular & Molecular Biology Letters1689-13922023-04-0128111110.1186/s11658-023-00441-0Can precancerous stem cells be risk markers for malignant transformation in the oral mucosa?Shan Wang0Liu Ying1Shu-Yi Yu2Jie Bai3Chunbo Hao4Department of Oral Pathology, School of Stomatology, Hainan Medical UniversityCollege of Pharmacy, Hainan Medical UniversityPharmacy Department, First Affiliated Hospital of Jiamusi UniversityDepartment of Ophthalmology, the Fourth Affiliated Hospital, Zhejiang University School of MedicineDepartment of Stomatology, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University)Abstract Accurate assessment of the carcinogenic potential of oral mucosal diseases can significantly reduce the prevalence of oral cancer. We speculate that precancerous stem cells (pCSCs) arise during the evolution of carcinomas based on long-term experimental findings, published literature, and the cancer stem cell (CSC) theory, wherein pCSCs exist in precancerous lesions and have characteristics of both CSCs and normal stem cells. This apparently contradictory feature may be the foundation of the reversible transformation of precancerous lesions. Predicting malignant transformation in potentially malignant oral illnesses would allow for focused treatment, prognosis, and secondary prevention. Currently available clinical assays for chromosomal instability and DNA aneuploidy have several deficiencies. We hope that our study will increase attention to pCSC research and lead to the development of novel strategies for the prevention and treatment of oral cancer by identifying pCSC markers. Graphical Abstracthttps://doi.org/10.1186/s11658-023-00441-0Precancerous stem cellsCancer stem cellsOral cancerDysplasiaMalignant transformation |
| spellingShingle | Shan Wang Liu Ying Shu-Yi Yu Jie Bai Chunbo Hao Can precancerous stem cells be risk markers for malignant transformation in the oral mucosa? Cellular & Molecular Biology Letters Precancerous stem cells Cancer stem cells Oral cancer Dysplasia Malignant transformation |
| title | Can precancerous stem cells be risk markers for malignant transformation in the oral mucosa? |
| title_full | Can precancerous stem cells be risk markers for malignant transformation in the oral mucosa? |
| title_fullStr | Can precancerous stem cells be risk markers for malignant transformation in the oral mucosa? |
| title_full_unstemmed | Can precancerous stem cells be risk markers for malignant transformation in the oral mucosa? |
| title_short | Can precancerous stem cells be risk markers for malignant transformation in the oral mucosa? |
| title_sort | can precancerous stem cells be risk markers for malignant transformation in the oral mucosa |
| topic | Precancerous stem cells Cancer stem cells Oral cancer Dysplasia Malignant transformation |
| url | https://doi.org/10.1186/s11658-023-00441-0 |
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