The prevalence, serogroup distribution and risk factors of meningococcal carriage in adolescents and young adults in Turkey
The serogroup epidemiology of invasive meningococcal disease (IMD), which varies considerably by geographic region and immunization schedule, changes continuously. Meningococcal carriage data are crucial for assessing IMD epidemiology and designing f potential vaccination strategies. Meningococcal s...
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2017-05-01
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| Series: | Human Vaccines & Immunotherapeutics |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/21645515.2016.1268304 |
| _version_ | 1797674537080324096 |
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| author | Rahmi Tuna Tekin Ener Cagri Dinleyici Mehmet Ceyhan Adem Karbuz Nuran Salman Murat Sutçu Zafer Kurugol Yasemin Balliel Melda Celik Mustafa Hacimustafaoglu Necdet Kuyucu Meda Kondolot Gülnar Sensoy Ozge Metin Soner Sertan Kara Meltem Dinleyici Omer Kılıç Cihangul Bayhan Venhar Gurbuz Emre Aycan Aygun Memedova Arzu Karli Gulçin Bozlu Solmaz Celebi |
| author_facet | Rahmi Tuna Tekin Ener Cagri Dinleyici Mehmet Ceyhan Adem Karbuz Nuran Salman Murat Sutçu Zafer Kurugol Yasemin Balliel Melda Celik Mustafa Hacimustafaoglu Necdet Kuyucu Meda Kondolot Gülnar Sensoy Ozge Metin Soner Sertan Kara Meltem Dinleyici Omer Kılıç Cihangul Bayhan Venhar Gurbuz Emre Aycan Aygun Memedova Arzu Karli Gulçin Bozlu Solmaz Celebi |
| author_sort | Rahmi Tuna Tekin |
| collection | DOAJ |
| description | The serogroup epidemiology of invasive meningococcal disease (IMD), which varies considerably by geographic region and immunization schedule, changes continuously. Meningococcal carriage data are crucial for assessing IMD epidemiology and designing f potential vaccination strategies. Meningococcal seroepidemiology in Turkey differs from that in other countries: serogroups W and B are the predominant strains for IMD during childhood, whereas no serogroup C cases were identified over the last 10 y and no adolescent peak for IMD was found. There is a lack of data on meningococcal carriage that represents the whole population. The aims of this multicenter study (12 cities in Turkey) were to evaluate the prevalence of Neisseria meningitidis carriage, the serogroup distribution and the related risk factors (educational status, living in a dormitory or student house, being a household contact with Hajj pilgrims, smoking, completion of military service, attending bars/clubs) in 1518 adolescents and young adults aged 10–24 y. The presence of N. meningitidis DNA was tested, and a serogroup analysis was performed using polymerase chain reaction. The overall meningococcal carriage rate was 6.3% (n = 96) in the study population. A serogroup distribution of the 96 N. meningitidis strains isolated from the nasopharyngeal specimens revealed serogroup A in 5 specimens (5.2%), serogroup B in 9 specimens (9.4%), serogroup W in 64 specimens (66.6%), and serogroup Y in 4 specimens (4.2%); 14 were classified as non-grouped (14.4%). No serogroup C cases were detected. The nasopharyngeal meningococcal carriage rate was 5% in the 10–14 age group, 6.4% in the 15–17 age-group, and 4.7% in the 18–20 age group; the highest carriage rate was found in the 21–24 age group (9.1%), which was significantly higher than those of the other age groups (p < 0.05). The highest carriage rate was found in 17-year-old adolescents (11%). The carriage rate was higher among the participants who had had close contact with Hajj/Umrah pilgrims (p < 0.01) or a history of upper respiratory tract infections over the past 3 months (p < 0.05). The nasopharyngeal carriage rate was 6.3% among adolescents and young adults in Turkey and was similar to the recent rates observed in the same age groups in other countries. The most prevalent serogroup was W, and no serogroup C cases were found. In conclusion, the present study found that meningococcal carriage reaches its peak level by age 17, the highest carriage rate was found in 21 - to 24 - year-olds and the majority of the carriage cases were due to serogroup W. Adolescents and young adult carriers seem to be a potential reservoir for the disease, and further immunization strategies, including adolescent immunization, may play a role in the control of IMD. |
| first_indexed | 2024-03-11T22:01:30Z |
| format | Article |
| id | doaj.art-391ff9044ce64771b25452c5eac65577 |
| institution | Directory Open Access Journal |
| issn | 2164-5515 2164-554X |
| language | English |
| last_indexed | 2024-03-11T22:01:30Z |
| publishDate | 2017-05-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj.art-391ff9044ce64771b25452c5eac655772023-09-25T11:00:55ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2017-05-011351182118910.1080/21645515.2016.12683041268304The prevalence, serogroup distribution and risk factors of meningococcal carriage in adolescents and young adults in TurkeyRahmi Tuna Tekin0Ener Cagri Dinleyici1Mehmet Ceyhan2Adem Karbuz3Nuran Salman4Murat Sutçu5Zafer Kurugol6Yasemin Balliel7Melda Celik8Mustafa Hacimustafaoglu9Necdet Kuyucu10Meda Kondolot11Gülnar Sensoy12Ozge Metin13Soner Sertan Kara14Meltem Dinleyici15Omer Kılıç16Cihangul Bayhan17Venhar Gurbuz18Emre Aycan19Aygun Memedova20Arzu Karli21Gulçin Bozlu22Solmaz Celebi23Eskisehir Osmangazi University Faculty of MedicineEskisehir Osmangazi University Faculty of MedicinePediatric Infectious Disease UnitOkmeydanı Training and Research Hospital, Pediatric Infectious Disease UnitIstanbul University Istanbul Faculty of Medicine, Pediatric Infectious Disease UnitIstanbul University Istanbul Faculty of Medicine, Pediatric Infectious Disease UnitEge University Faculty of Medicine, Pediatric Infectious Disease UnitMuratpasa 1st Caybasi Family Practice CenterSanlıurfa Children HospitalPediatric Infectious Disease UnitPediatric Infectious Disease UnitErciyes University Faculty of MedicineKonya Training and Research Hospital, Pediatric Infectious Disease UnitPediatric Infectious Disease UnitErzurum Training and Research Hospital, Pediatric Infectious Disease UnitEskisehir Osmangazi University Faculty of MedicineEskisehir Osmangazi University Faculty of MedicinePediatric Infectious Disease UnitPediatric Infectious Disease UnitPediatric Infectious Disease UnitEge University Faculty of Medicine, Pediatric Infectious Disease UnitKonya Training and Research Hospital, Pediatric Infectious Disease UnitPediatric Infectious Disease UnitPediatric Infectious Disease UnitThe serogroup epidemiology of invasive meningococcal disease (IMD), which varies considerably by geographic region and immunization schedule, changes continuously. Meningococcal carriage data are crucial for assessing IMD epidemiology and designing f potential vaccination strategies. Meningococcal seroepidemiology in Turkey differs from that in other countries: serogroups W and B are the predominant strains for IMD during childhood, whereas no serogroup C cases were identified over the last 10 y and no adolescent peak for IMD was found. There is a lack of data on meningococcal carriage that represents the whole population. The aims of this multicenter study (12 cities in Turkey) were to evaluate the prevalence of Neisseria meningitidis carriage, the serogroup distribution and the related risk factors (educational status, living in a dormitory or student house, being a household contact with Hajj pilgrims, smoking, completion of military service, attending bars/clubs) in 1518 adolescents and young adults aged 10–24 y. The presence of N. meningitidis DNA was tested, and a serogroup analysis was performed using polymerase chain reaction. The overall meningococcal carriage rate was 6.3% (n = 96) in the study population. A serogroup distribution of the 96 N. meningitidis strains isolated from the nasopharyngeal specimens revealed serogroup A in 5 specimens (5.2%), serogroup B in 9 specimens (9.4%), serogroup W in 64 specimens (66.6%), and serogroup Y in 4 specimens (4.2%); 14 were classified as non-grouped (14.4%). No serogroup C cases were detected. The nasopharyngeal meningococcal carriage rate was 5% in the 10–14 age group, 6.4% in the 15–17 age-group, and 4.7% in the 18–20 age group; the highest carriage rate was found in the 21–24 age group (9.1%), which was significantly higher than those of the other age groups (p < 0.05). The highest carriage rate was found in 17-year-old adolescents (11%). The carriage rate was higher among the participants who had had close contact with Hajj/Umrah pilgrims (p < 0.01) or a history of upper respiratory tract infections over the past 3 months (p < 0.05). The nasopharyngeal carriage rate was 6.3% among adolescents and young adults in Turkey and was similar to the recent rates observed in the same age groups in other countries. The most prevalent serogroup was W, and no serogroup C cases were found. In conclusion, the present study found that meningococcal carriage reaches its peak level by age 17, the highest carriage rate was found in 21 - to 24 - year-olds and the majority of the carriage cases were due to serogroup W. Adolescents and young adult carriers seem to be a potential reservoir for the disease, and further immunization strategies, including adolescent immunization, may play a role in the control of IMD.http://dx.doi.org/10.1080/21645515.2016.1268304adolescentsmeningococcimeningococcal vaccinesnasopharyngeal colonizationneisseria meningitidisturkey |
| spellingShingle | Rahmi Tuna Tekin Ener Cagri Dinleyici Mehmet Ceyhan Adem Karbuz Nuran Salman Murat Sutçu Zafer Kurugol Yasemin Balliel Melda Celik Mustafa Hacimustafaoglu Necdet Kuyucu Meda Kondolot Gülnar Sensoy Ozge Metin Soner Sertan Kara Meltem Dinleyici Omer Kılıç Cihangul Bayhan Venhar Gurbuz Emre Aycan Aygun Memedova Arzu Karli Gulçin Bozlu Solmaz Celebi The prevalence, serogroup distribution and risk factors of meningococcal carriage in adolescents and young adults in Turkey Human Vaccines & Immunotherapeutics adolescents meningococci meningococcal vaccines nasopharyngeal colonization neisseria meningitidis turkey |
| title | The prevalence, serogroup distribution and risk factors of meningococcal carriage in adolescents and young adults in Turkey |
| title_full | The prevalence, serogroup distribution and risk factors of meningococcal carriage in adolescents and young adults in Turkey |
| title_fullStr | The prevalence, serogroup distribution and risk factors of meningococcal carriage in adolescents and young adults in Turkey |
| title_full_unstemmed | The prevalence, serogroup distribution and risk factors of meningococcal carriage in adolescents and young adults in Turkey |
| title_short | The prevalence, serogroup distribution and risk factors of meningococcal carriage in adolescents and young adults in Turkey |
| title_sort | prevalence serogroup distribution and risk factors of meningococcal carriage in adolescents and young adults in turkey |
| topic | adolescents meningococci meningococcal vaccines nasopharyngeal colonization neisseria meningitidis turkey |
| url | http://dx.doi.org/10.1080/21645515.2016.1268304 |
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