Electrostatic catalysis of a click reaction in a microfluidic cell
Abstract Electric fields have been highlighted as a smart reagent in nature’s enzymatic machinery, as they can directly trigger or accelerate chemical processes with stereo- and regio-specificity. In enzymatic catalysis, controlled mass transport of chemical species is also key in facilitating the a...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-024-44716-2 |
| _version_ | 1797276389269831680 |
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| author | Semih Sevim Roger Sanchis-Gual Carlos Franco Albert C. Aragonès Nadim Darwish Donghoon Kim Rosaria Anna Picca Bradley J. Nelson Eliseo Ruiz Salvador Pané Ismael Díez-Pérez Josep Puigmartí-Luis |
| author_facet | Semih Sevim Roger Sanchis-Gual Carlos Franco Albert C. Aragonès Nadim Darwish Donghoon Kim Rosaria Anna Picca Bradley J. Nelson Eliseo Ruiz Salvador Pané Ismael Díez-Pérez Josep Puigmartí-Luis |
| author_sort | Semih Sevim |
| collection | DOAJ |
| description | Abstract Electric fields have been highlighted as a smart reagent in nature’s enzymatic machinery, as they can directly trigger or accelerate chemical processes with stereo- and regio-specificity. In enzymatic catalysis, controlled mass transport of chemical species is also key in facilitating the availability of reactants in the active reaction site. However, recent progress in developing a clean catalysis that profits from oriented electric fields is limited to theoretical and experimental studies at the single molecule level, where both the control over mass transport and scalability cannot be tested. Here, we quantify the electrostatic catalysis of a prototypical Huisgen cycloaddition in a large-area electrode surface and directly compare its performance to the conventional Cu(I) catalysis. Our custom-built microfluidic cell enhances reagent transport towards the electrified reactive interface. This continuous-flow microfluidic electrostatic reactor is an example of an electric-field driven platform where clean large-scale electrostatic catalytic processes can be efficiently implemented and regulated. |
| first_indexed | 2024-03-07T15:27:36Z |
| format | Article |
| id | doaj.art-3922ca7463584fb4814cf95941ca94bd |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-03-07T15:27:36Z |
| publishDate | 2024-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-3922ca7463584fb4814cf95941ca94bd2024-03-05T16:35:54ZengNature PortfolioNature Communications2041-17232024-01-011511910.1038/s41467-024-44716-2Electrostatic catalysis of a click reaction in a microfluidic cellSemih Sevim0Roger Sanchis-Gual1Carlos Franco2Albert C. Aragonès3Nadim Darwish4Donghoon Kim5Rosaria Anna Picca6Bradley J. Nelson7Eliseo Ruiz8Salvador Pané9Ismael Díez-Pérez10Josep Puigmartí-Luis11Institute of Robotics and Intelligent Systems, ETH ZurichInstitute of Robotics and Intelligent Systems, ETH ZurichInstitute of Robotics and Intelligent Systems, ETH ZurichDepartament de Ciència de Materials i Química Física, Institut de Química Teòrica i Computacional, University of Barcelona (UB)School of Molecular and Life Sciences, Curtin UniversityInstitute of Robotics and Intelligent Systems, ETH ZurichChemistry Department, University of Bari “Aldo Moro”Institute of Robotics and Intelligent Systems, ETH ZurichDepartament de Química Inorgànica i Orgànica, Institut de Química Teòrica i Computacional, University of Barcelona (UB)Institute of Robotics and Intelligent Systems, ETH ZurichDepartment of Chemistry, Faculty of Natural, Mathematical & Engineering Sciences, King’s College LondonDepartament de Ciència de Materials i Química Física, Institut de Química Teòrica i Computacional, University of Barcelona (UB)Abstract Electric fields have been highlighted as a smart reagent in nature’s enzymatic machinery, as they can directly trigger or accelerate chemical processes with stereo- and regio-specificity. In enzymatic catalysis, controlled mass transport of chemical species is also key in facilitating the availability of reactants in the active reaction site. However, recent progress in developing a clean catalysis that profits from oriented electric fields is limited to theoretical and experimental studies at the single molecule level, where both the control over mass transport and scalability cannot be tested. Here, we quantify the electrostatic catalysis of a prototypical Huisgen cycloaddition in a large-area electrode surface and directly compare its performance to the conventional Cu(I) catalysis. Our custom-built microfluidic cell enhances reagent transport towards the electrified reactive interface. This continuous-flow microfluidic electrostatic reactor is an example of an electric-field driven platform where clean large-scale electrostatic catalytic processes can be efficiently implemented and regulated.https://doi.org/10.1038/s41467-024-44716-2 |
| spellingShingle | Semih Sevim Roger Sanchis-Gual Carlos Franco Albert C. Aragonès Nadim Darwish Donghoon Kim Rosaria Anna Picca Bradley J. Nelson Eliseo Ruiz Salvador Pané Ismael Díez-Pérez Josep Puigmartí-Luis Electrostatic catalysis of a click reaction in a microfluidic cell Nature Communications |
| title | Electrostatic catalysis of a click reaction in a microfluidic cell |
| title_full | Electrostatic catalysis of a click reaction in a microfluidic cell |
| title_fullStr | Electrostatic catalysis of a click reaction in a microfluidic cell |
| title_full_unstemmed | Electrostatic catalysis of a click reaction in a microfluidic cell |
| title_short | Electrostatic catalysis of a click reaction in a microfluidic cell |
| title_sort | electrostatic catalysis of a click reaction in a microfluidic cell |
| url | https://doi.org/10.1038/s41467-024-44716-2 |
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