2-pentadecyl-2-oxazoline prevents cognitive and social behaviour impairments in the Amyloid β-induced Alzheimer-like mice model: Bring the α2 adrenergic receptor back into play

2-pentadecyl-2-oxazoline prevents cognitive and social behaviour impairments in the Amyloid β-induced Alzheimer-like mice model: Bring the α2 adrenergic receptor back into play

The 2-pentadecyl-2-oxazoline (PEA-OXA) is a natural compound with protective action in neuro-inflammation. We have previously shown that PEA-OXA behaves as an α2 adrenergic receptor (α2AR) antagonist and a putative protean agonist on histamine H3 receptors. Recently, neuroinflammation and monoaminer...

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Bibliographic Details
Main Authors: R. Infantino, S. Boccella, D. Scuteri, M. Perrone, F. Ricciardi, R.M. Vitale, R. Bonsale, A. Parente, I. Allocca, A. Virtuoso, C. De Luca, C. Belardo, P. Amodeo, V. Gentile, G. Cirillo, G. Bagetta, L. Luongo, S. Maione, F. Guida
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Amyloid β (1−42)
α2 adrenergic receptor
Alzheimer Disease
2-pentadecyl-2-oxazoline
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332222012331

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