Anthocyanin, tartaric acid, ascorbic acid of roselle flower (Hibiscus sabdariffa L.) for immunomodulatory adjuvant therapy in oral manifestation coronavirus disease-19: An immunoinformatic approach
Context: Oral manifestations that arose from COVID-19 infection often causes morbidity and systemic drug administration is less effective. Roselle flower (Hibiscus sabdariffa) is one of the plants that is often used in infusion as it gives health benefits. Hence, H. sabdariffa may benefit from adjuv...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
GarVal Editorial Ltda.
2022-05-01
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| Series: | Journal of Pharmacy & Pharmacognosy Research |
| Subjects: | |
| Online Access: | https://jppres.com/jppres/pdf/vol10/jppres21.1316_10.3.418.pdf |
| _version_ | 1818285602162868224 |
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| author | Nastiti Faradilla Ramadhani Alexander Patera Nugraha Desintya Rahmadhani Martining Shoffa Puspitaningrum Yuniar Rizqianti Viol Dhea Kharisma Tengku Natasha Eleena binti Tengku Ahmad Noor Rini Devijanti Ridwan Diah Savitri Ernawati Albertus Putera Nugraha |
| author_facet | Nastiti Faradilla Ramadhani Alexander Patera Nugraha Desintya Rahmadhani Martining Shoffa Puspitaningrum Yuniar Rizqianti Viol Dhea Kharisma Tengku Natasha Eleena binti Tengku Ahmad Noor Rini Devijanti Ridwan Diah Savitri Ernawati Albertus Putera Nugraha |
| author_sort | Nastiti Faradilla Ramadhani |
| collection | DOAJ |
| description | Context: Oral manifestations that arose from COVID-19 infection often causes morbidity and systemic drug administration is less effective. Roselle flower (Hibiscus sabdariffa) is one of the plants that is often used in infusion as it gives health benefits. Hence, H. sabdariffa may benefit from adjuvant therapy to treat oral manifestation due to COVID-19.
Aims: To investigate the potential of H. sabdariffa anthocyanins, tartaric acid, and ascorbic acid chemical compounds as antiviral, anti-inflammatory, antioxidant, and increasing tissue regeneration in oral manifestation due to COVID-19 infection in silico.
Methods: Chemical compounds consisted of anthocyanins, (+)-tartaric acid, and ascorbic acid beside target proteins consisted of ACE2-spike, Foxp3, IL-10, IL6, IL1β, VEGF, FGF-2, HSP70, TNFR and MDA-ovalbumin were obtained from the database, ligand samples were selected through absorption, distribution, metabolism, excretion and toxicology analysis, then molecular docking simulations, identification of protein-ligand interactions, and 3D visualization were performed.
Results: Anthocyanins, tartaric acid, and ascorbic acid are the active compounds in H. sabdariffa, which act as antioxidants. The activity of anthocyanin compounds is higher than other compounds through value binding affinity, which is more negative and binds to specific domains of target proteins by forming weak binding interactions that play a role in biological responses. Anthocyanins have the most negative binding energy compared to tartaric-acid and ascorbic acid.
Conclusions: Anthocyanins act as antioxidants; this mechanism increases heat shock protein-70 (HSP70), which may play an important role in increasing wound regeneration of oral manifestation in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as documented in silico. |
| first_indexed | 2024-12-13T01:11:18Z |
| format | Article |
| id | doaj.art-39239b3373224301bd55a03133b58ddd |
| institution | Directory Open Access Journal |
| issn | 0719-4250 |
| language | English |
| last_indexed | 2024-12-13T01:11:18Z |
| publishDate | 2022-05-01 |
| publisher | GarVal Editorial Ltda. |
| record_format | Article |
| series | Journal of Pharmacy & Pharmacognosy Research |
| spelling | doaj.art-39239b3373224301bd55a03133b58ddd2022-12-22T00:04:28ZengGarVal Editorial Ltda.Journal of Pharmacy & Pharmacognosy Research0719-42502022-05-01103418428Anthocyanin, tartaric acid, ascorbic acid of roselle flower (Hibiscus sabdariffa L.) for immunomodulatory adjuvant therapy in oral manifestation coronavirus disease-19: An immunoinformatic approachNastiti Faradilla Ramadhani0Alexander Patera Nugraha1Desintya Rahmadhani2Martining Shoffa Puspitaningrum3Yuniar Rizqianti4Viol Dhea Kharisma5Tengku Natasha Eleena binti Tengku Ahmad Noor6Rini Devijanti Ridwan7Diah Savitri Ernawati8Albertus Putera Nugraha9Graduate Student of Dental Health Science, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.Graduate Student of Dental Health Science, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia. Department of Orthodontic, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.Viol Dhea KharismaMilitary Dental Officer of Royal Medical and Dental Corps, Malaysian Armed Forces, Indonesia.Department of Oral Biology, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.Department of Oral Medicine, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.Context: Oral manifestations that arose from COVID-19 infection often causes morbidity and systemic drug administration is less effective. Roselle flower (Hibiscus sabdariffa) is one of the plants that is often used in infusion as it gives health benefits. Hence, H. sabdariffa may benefit from adjuvant therapy to treat oral manifestation due to COVID-19. Aims: To investigate the potential of H. sabdariffa anthocyanins, tartaric acid, and ascorbic acid chemical compounds as antiviral, anti-inflammatory, antioxidant, and increasing tissue regeneration in oral manifestation due to COVID-19 infection in silico. Methods: Chemical compounds consisted of anthocyanins, (+)-tartaric acid, and ascorbic acid beside target proteins consisted of ACE2-spike, Foxp3, IL-10, IL6, IL1β, VEGF, FGF-2, HSP70, TNFR and MDA-ovalbumin were obtained from the database, ligand samples were selected through absorption, distribution, metabolism, excretion and toxicology analysis, then molecular docking simulations, identification of protein-ligand interactions, and 3D visualization were performed. Results: Anthocyanins, tartaric acid, and ascorbic acid are the active compounds in H. sabdariffa, which act as antioxidants. The activity of anthocyanin compounds is higher than other compounds through value binding affinity, which is more negative and binds to specific domains of target proteins by forming weak binding interactions that play a role in biological responses. Anthocyanins have the most negative binding energy compared to tartaric-acid and ascorbic acid. Conclusions: Anthocyanins act as antioxidants; this mechanism increases heat shock protein-70 (HSP70), which may play an important role in increasing wound regeneration of oral manifestation in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as documented in silico.https://jppres.com/jppres/pdf/vol10/jppres21.1316_10.3.418.pdfcovid-19dentistryhibiscus sabdariffainfectious diseasemedicine |
| spellingShingle | Nastiti Faradilla Ramadhani Alexander Patera Nugraha Desintya Rahmadhani Martining Shoffa Puspitaningrum Yuniar Rizqianti Viol Dhea Kharisma Tengku Natasha Eleena binti Tengku Ahmad Noor Rini Devijanti Ridwan Diah Savitri Ernawati Albertus Putera Nugraha Anthocyanin, tartaric acid, ascorbic acid of roselle flower (Hibiscus sabdariffa L.) for immunomodulatory adjuvant therapy in oral manifestation coronavirus disease-19: An immunoinformatic approach Journal of Pharmacy & Pharmacognosy Research covid-19 dentistry hibiscus sabdariffa infectious disease medicine |
| title | Anthocyanin, tartaric acid, ascorbic acid of roselle flower (Hibiscus sabdariffa L.) for immunomodulatory adjuvant therapy in oral manifestation coronavirus disease-19: An immunoinformatic approach |
| title_full | Anthocyanin, tartaric acid, ascorbic acid of roselle flower (Hibiscus sabdariffa L.) for immunomodulatory adjuvant therapy in oral manifestation coronavirus disease-19: An immunoinformatic approach |
| title_fullStr | Anthocyanin, tartaric acid, ascorbic acid of roselle flower (Hibiscus sabdariffa L.) for immunomodulatory adjuvant therapy in oral manifestation coronavirus disease-19: An immunoinformatic approach |
| title_full_unstemmed | Anthocyanin, tartaric acid, ascorbic acid of roselle flower (Hibiscus sabdariffa L.) for immunomodulatory adjuvant therapy in oral manifestation coronavirus disease-19: An immunoinformatic approach |
| title_short | Anthocyanin, tartaric acid, ascorbic acid of roselle flower (Hibiscus sabdariffa L.) for immunomodulatory adjuvant therapy in oral manifestation coronavirus disease-19: An immunoinformatic approach |
| title_sort | anthocyanin tartaric acid ascorbic acid of roselle flower hibiscus sabdariffa l for immunomodulatory adjuvant therapy in oral manifestation coronavirus disease 19 an immunoinformatic approach |
| topic | covid-19 dentistry hibiscus sabdariffa infectious disease medicine |
| url | https://jppres.com/jppres/pdf/vol10/jppres21.1316_10.3.418.pdf |
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