A serious adverse drug reaction probably induced by clonazepam: a case report of myotoxicity
Abstract Background The adverse drug reactions (ADRs) related to clonazepam are mild, and only two cases of myotoxicity induced by clonazepam have been reported, with both patients recovering well. We present a unique case of a serious ADR outcome after taking clonazepam. Case presentation A 24-year...
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| Format: | Article |
| Language: | English |
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BMC
2019-11-01
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| Series: | BMC Pharmacology and Toxicology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s40360-019-0366-y |
| _version_ | 1818404118123773952 |
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| author | Xiaonian Han Jinping Wang |
| author_facet | Xiaonian Han Jinping Wang |
| author_sort | Xiaonian Han |
| collection | DOAJ |
| description | Abstract Background The adverse drug reactions (ADRs) related to clonazepam are mild, and only two cases of myotoxicity induced by clonazepam have been reported, with both patients recovering well. We present a unique case of a serious ADR outcome after taking clonazepam. Case presentation A 24-year-old woman with a long-standing history of polio and a 2-year history of epilepsy developed a serious ADR after repeated exposure to oral clonazepam combined with sodium valproate that manifested as myotoxicity and elevated levels of creatine phosphokinase. The patient is currently bedridden and unable to take care of herself. Conclusion Clinicians should be vigilant of the possibility of myotoxicity induced by clonazepam, especially in specific populations such as polio patients or when clonazepam is used in combination therapies. |
| first_indexed | 2024-12-14T08:35:04Z |
| format | Article |
| id | doaj.art-39239f73befa40ee99eba68327da3eaa |
| institution | Directory Open Access Journal |
| issn | 2050-6511 |
| language | English |
| last_indexed | 2024-12-14T08:35:04Z |
| publishDate | 2019-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pharmacology and Toxicology |
| spelling | doaj.art-39239f73befa40ee99eba68327da3eaa2022-12-21T23:09:25ZengBMCBMC Pharmacology and Toxicology2050-65112019-11-012011410.1186/s40360-019-0366-yA serious adverse drug reaction probably induced by clonazepam: a case report of myotoxicityXiaonian Han0Jinping Wang1Department of Pharmacy, Xi’an Central HospitalDepartment of Pharmacy, Xi’an Central HospitalAbstract Background The adverse drug reactions (ADRs) related to clonazepam are mild, and only two cases of myotoxicity induced by clonazepam have been reported, with both patients recovering well. We present a unique case of a serious ADR outcome after taking clonazepam. Case presentation A 24-year-old woman with a long-standing history of polio and a 2-year history of epilepsy developed a serious ADR after repeated exposure to oral clonazepam combined with sodium valproate that manifested as myotoxicity and elevated levels of creatine phosphokinase. The patient is currently bedridden and unable to take care of herself. Conclusion Clinicians should be vigilant of the possibility of myotoxicity induced by clonazepam, especially in specific populations such as polio patients or when clonazepam is used in combination therapies.http://link.springer.com/article/10.1186/s40360-019-0366-yMyotoxicityCreatine phosphokinaseClonazepamPolio |
| spellingShingle | Xiaonian Han Jinping Wang A serious adverse drug reaction probably induced by clonazepam: a case report of myotoxicity BMC Pharmacology and Toxicology Myotoxicity Creatine phosphokinase Clonazepam Polio |
| title | A serious adverse drug reaction probably induced by clonazepam: a case report of myotoxicity |
| title_full | A serious adverse drug reaction probably induced by clonazepam: a case report of myotoxicity |
| title_fullStr | A serious adverse drug reaction probably induced by clonazepam: a case report of myotoxicity |
| title_full_unstemmed | A serious adverse drug reaction probably induced by clonazepam: a case report of myotoxicity |
| title_short | A serious adverse drug reaction probably induced by clonazepam: a case report of myotoxicity |
| title_sort | serious adverse drug reaction probably induced by clonazepam a case report of myotoxicity |
| topic | Myotoxicity Creatine phosphokinase Clonazepam Polio |
| url | http://link.springer.com/article/10.1186/s40360-019-0366-y |
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