Hair Cortisol Concentration, Weight Loss Maintenance and Body Weight Variability: A Prospective Study Based on Data From the European NoHoW Trial
Several cross-sectional studies have shown hair cortisol concentration to be associated with adiposity, but the relationship between hair cortisol concentration and longitudinal changes in measures of adiposity are largely unknown. We included 786 adults from the NoHoW trial, who had achieved a succ...
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Frontiers Media S.A.
2021-09-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2021.655197/full |
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| author | Sofus C. Larsen Jake Turicchi Gitte L. Christensen Charlotte S. Larsen Niklas R. Jørgensen Niklas R. Jørgensen Marie-Louise K. Mikkelsen Graham Horgan Ruairi O’Driscoll Joanna Michalowska Joanna Michalowska Cristiana Duarte Sarah E. Scott Inês Santos Inês Santos Inês Santos Jorge Encantado Jorge Encantado Antonio L. Palmeira Antonio L. Palmeira R. James Stubbs Berit L. Heitmann Berit L. Heitmann Berit L. Heitmann |
| author_facet | Sofus C. Larsen Jake Turicchi Gitte L. Christensen Charlotte S. Larsen Niklas R. Jørgensen Niklas R. Jørgensen Marie-Louise K. Mikkelsen Graham Horgan Ruairi O’Driscoll Joanna Michalowska Joanna Michalowska Cristiana Duarte Sarah E. Scott Inês Santos Inês Santos Inês Santos Jorge Encantado Jorge Encantado Antonio L. Palmeira Antonio L. Palmeira R. James Stubbs Berit L. Heitmann Berit L. Heitmann Berit L. Heitmann |
| author_sort | Sofus C. Larsen |
| collection | DOAJ |
| description | Several cross-sectional studies have shown hair cortisol concentration to be associated with adiposity, but the relationship between hair cortisol concentration and longitudinal changes in measures of adiposity are largely unknown. We included 786 adults from the NoHoW trial, who had achieved a successful weight loss of ≥5% and had a body mass index of ≥25 kg/m2 prior to losing weight. Hair cortisol concentration (pg/mg hair) was measured at baseline and after 12 months. Body weight and body fat percentage were measured at baseline, 6-month, 12-month and 18-month visits. Participants weighed themselves at home ≥2 weekly using a Wi-Fi scale for the 18-month study duration, from which body weight variability was estimated using linear and non-linear approaches. Regression models were conducted to examine log hair cortisol concentration and change in log hair cortisol concentration as predictors of changes in body weight, change in body fat percentage and body weight variability. After adjustment for lifestyle and demographic factors, no associations between baseline log hair cortisol concentration and outcome measures were observed. Similar results were seen when analysing the association between 12-month concurrent development in log hair cortisol concentration and outcomes. However, an initial 12-month increase in log hair cortisol concentration was associated with a higher subsequent body weight variability between month 12 and 18, based on deviations from a nonlinear trend (β: 0.02% per unit increase in log hair cortisol concentration [95% CI: 0.00, 0.04]; P=0.016). Our data suggest that an association between hair cortisol concentration and subsequent change in body weight or body fat percentage is absent or marginal, but that an increase in hair cortisol concentration during a 12-month weight loss maintenance effort may predict a slightly higher subsequent 6-months body weight variability.Clinical Trial RegistrationISRCTN registry, identifier ISRCTN88405328. |
| first_indexed | 2024-12-14T19:06:21Z |
| format | Article |
| id | doaj.art-3926d14e2fa84d319d95584064781516 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-14T19:06:21Z |
| publishDate | 2021-09-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Endocrinology |
| spelling | doaj.art-3926d14e2fa84d319d955840647815162022-12-21T22:50:51ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922021-09-011210.3389/fendo.2021.655197655197Hair Cortisol Concentration, Weight Loss Maintenance and Body Weight Variability: A Prospective Study Based on Data From the European NoHoW TrialSofus C. Larsen0Jake Turicchi1Gitte L. Christensen2Charlotte S. Larsen3Niklas R. Jørgensen4Niklas R. Jørgensen5Marie-Louise K. Mikkelsen6Graham Horgan7Ruairi O’Driscoll8Joanna Michalowska9Joanna Michalowska10Cristiana Duarte11Sarah E. Scott12Inês Santos13Inês Santos14Inês Santos15Jorge Encantado16Jorge Encantado17Antonio L. Palmeira18Antonio L. Palmeira19R. James Stubbs20Berit L. Heitmann21Berit L. Heitmann22Berit L. Heitmann23Research Unit for Dietary Studies, The Parker Institute, Bispebjerg and Frederiksberg Hospital, The Capital Region, Frederiksberg, DenmarkSchool of Psychology, Faculty of Medicine and Health, University of Leeds, Leeds, United KingdomDepartment of Clinical Biochemistry, Rigshospitalet, Glostrup, DenmarkDepartment of Clinical Biochemistry, Rigshospitalet, Glostrup, DenmarkDepartment of Clinical Biochemistry, Rigshospitalet, Glostrup, DenmarkDepartment of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DenmarkResearch Unit for Dietary Studies, The Parker Institute, Bispebjerg and Frederiksberg Hospital, The Capital Region, Frederiksberg, DenmarkBiomathematics and Statistics Scotland, Aberdeen, United KingdomSchool of Psychology, Faculty of Medicine and Health, University of Leeds, Leeds, United KingdomSchool of Psychology, Faculty of Medicine and Health, University of Leeds, Leeds, United KingdomDepartment of Treatment of Obesity, Metabolic Disorders and Clinical Dietetics, Poznan University of Medical Sciences, Poznan, PolandSchool of Psychology, Faculty of Medicine and Health, University of Leeds, Leeds, United KingdomSchool of Psychology, Faculty of Medicine and Health, University of Leeds, Leeds, United KingdomLaboratório de Nutrição, Faculdade de Medicina, Universidade de Lisboa, Lisbon, PortugalCentro Interdisciplinar para o Estudo da Performance Humana, Faculdade de Motricidade Humana, Universidade de Lisboa, Lisbon, PortugalCentro de Investigação em Desporto, Educação Física, Exercício e Saúde (CIDEFES), Universidade Lusófona, Lisbon, PortugalCentro Interdisciplinar para o Estudo da Performance Humana, Faculdade de Motricidade Humana, Universidade de Lisboa, Lisbon, Portugal0Applied Psychology Research Center Capabilities & Inclusion (APPsyCI), Instituto Superior de Psicologia Aplicada (ISPA) - Instituto Universitário, Lisbon, PortugalCentro Interdisciplinar para o Estudo da Performance Humana, Faculdade de Motricidade Humana, Universidade de Lisboa, Lisbon, PortugalCentro de Investigação em Desporto, Educação Física, Exercício e Saúde (CIDEFES), Universidade Lusófona, Lisbon, PortugalSchool of Psychology, Faculty of Medicine and Health, University of Leeds, Leeds, United KingdomResearch Unit for Dietary Studies, The Parker Institute, Bispebjerg and Frederiksberg Hospital, The Capital Region, Frederiksberg, Denmark1The Boden Institute of Obesity, Nutrition, Exercise & Eating Disorders, The University of Sydney, Sydney, NSW, Australia2Department of Public Health, Section for General Practice, University of Copenhagen, Copenhagen, DenmarkSeveral cross-sectional studies have shown hair cortisol concentration to be associated with adiposity, but the relationship between hair cortisol concentration and longitudinal changes in measures of adiposity are largely unknown. We included 786 adults from the NoHoW trial, who had achieved a successful weight loss of ≥5% and had a body mass index of ≥25 kg/m2 prior to losing weight. Hair cortisol concentration (pg/mg hair) was measured at baseline and after 12 months. Body weight and body fat percentage were measured at baseline, 6-month, 12-month and 18-month visits. Participants weighed themselves at home ≥2 weekly using a Wi-Fi scale for the 18-month study duration, from which body weight variability was estimated using linear and non-linear approaches. Regression models were conducted to examine log hair cortisol concentration and change in log hair cortisol concentration as predictors of changes in body weight, change in body fat percentage and body weight variability. After adjustment for lifestyle and demographic factors, no associations between baseline log hair cortisol concentration and outcome measures were observed. Similar results were seen when analysing the association between 12-month concurrent development in log hair cortisol concentration and outcomes. However, an initial 12-month increase in log hair cortisol concentration was associated with a higher subsequent body weight variability between month 12 and 18, based on deviations from a nonlinear trend (β: 0.02% per unit increase in log hair cortisol concentration [95% CI: 0.00, 0.04]; P=0.016). Our data suggest that an association between hair cortisol concentration and subsequent change in body weight or body fat percentage is absent or marginal, but that an increase in hair cortisol concentration during a 12-month weight loss maintenance effort may predict a slightly higher subsequent 6-months body weight variability.Clinical Trial RegistrationISRCTN registry, identifier ISRCTN88405328.https://www.frontiersin.org/articles/10.3389/fendo.2021.655197/fullhair cortisolobesitystressweight lossweight loss maintenance |
| spellingShingle | Sofus C. Larsen Jake Turicchi Gitte L. Christensen Charlotte S. Larsen Niklas R. Jørgensen Niklas R. Jørgensen Marie-Louise K. Mikkelsen Graham Horgan Ruairi O’Driscoll Joanna Michalowska Joanna Michalowska Cristiana Duarte Sarah E. Scott Inês Santos Inês Santos Inês Santos Jorge Encantado Jorge Encantado Antonio L. Palmeira Antonio L. Palmeira R. James Stubbs Berit L. Heitmann Berit L. Heitmann Berit L. Heitmann Hair Cortisol Concentration, Weight Loss Maintenance and Body Weight Variability: A Prospective Study Based on Data From the European NoHoW Trial Frontiers in Endocrinology hair cortisol obesity stress weight loss weight loss maintenance |
| title | Hair Cortisol Concentration, Weight Loss Maintenance and Body Weight Variability: A Prospective Study Based on Data From the European NoHoW Trial |
| title_full | Hair Cortisol Concentration, Weight Loss Maintenance and Body Weight Variability: A Prospective Study Based on Data From the European NoHoW Trial |
| title_fullStr | Hair Cortisol Concentration, Weight Loss Maintenance and Body Weight Variability: A Prospective Study Based on Data From the European NoHoW Trial |
| title_full_unstemmed | Hair Cortisol Concentration, Weight Loss Maintenance and Body Weight Variability: A Prospective Study Based on Data From the European NoHoW Trial |
| title_short | Hair Cortisol Concentration, Weight Loss Maintenance and Body Weight Variability: A Prospective Study Based on Data From the European NoHoW Trial |
| title_sort | hair cortisol concentration weight loss maintenance and body weight variability a prospective study based on data from the european nohow trial |
| topic | hair cortisol obesity stress weight loss weight loss maintenance |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2021.655197/full |
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