Interleaved Pro/Anti-saccade Behavior Across the Lifespan
The capacity for inhibitory control is an important cognitive process that undergoes dynamic changes over the course of the lifespan. Robust characterization of this trajectory, considering age continuously and using flexible modeling techniques, is critical to advance our understanding of the neura...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2022.842549/full |
| _version_ | 1818204389245976576 |
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| author | Rachel Yep Matthew L. Smorenburg Heidi C. Riek Olivia G. Calancie Ryan H. Kirkpatrick Ryan H. Kirkpatrick Julia E. Perkins Jeff Huang Brian C. Coe Donald C. Brien Douglas P. Munoz Douglas P. Munoz Douglas P. Munoz |
| author_facet | Rachel Yep Matthew L. Smorenburg Heidi C. Riek Olivia G. Calancie Ryan H. Kirkpatrick Ryan H. Kirkpatrick Julia E. Perkins Jeff Huang Brian C. Coe Donald C. Brien Douglas P. Munoz Douglas P. Munoz Douglas P. Munoz |
| author_sort | Rachel Yep |
| collection | DOAJ |
| description | The capacity for inhibitory control is an important cognitive process that undergoes dynamic changes over the course of the lifespan. Robust characterization of this trajectory, considering age continuously and using flexible modeling techniques, is critical to advance our understanding of the neural mechanisms that differ in healthy aging and neurological disease. The interleaved pro/anti-saccade task (IPAST), in which pro- and anti-saccade trials are randomly interleaved within a block, provides a simple and sensitive means of assessing the neural circuitry underlying inhibitory control. We utilized IPAST data collected from a large cross-sectional cohort of normative participants (n = 604, 5–93 years of age), standardized pre-processing protocols, generalized additive modeling, and change point analysis to investigate the effect of age on saccade behavior and identify significant periods of change throughout the lifespan. Maturation of IPAST measures occurred throughout adolescence, while subsequent decline began as early as the mid-20s and continued into old age. Considering pro-saccade correct responses and anti-saccade direction errors made at express (short) and regular (long) latencies was crucial in differentiating developmental and aging processes. We additionally characterized the effect of age on voluntary override time, a novel measure describing the time at which voluntary processes begin to overcome automated processes on anti-saccade trials. Drawing on converging animal neurophysiology, human neuroimaging, and computational modeling literature, we propose potential frontal-parietal and frontal-striatal mechanisms that may mediate the behavioral changes revealed in our analysis. We liken the models presented here to “cognitive growth curves” which have important implications for improved detection of neurological disease states that emerge during vulnerable windows of developing and aging. |
| first_indexed | 2024-12-12T03:40:27Z |
| format | Article |
| id | doaj.art-3927e4065d544d1c887e224a89f8b712 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-12-12T03:40:27Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-3927e4065d544d1c887e224a89f8b7122022-12-22T00:39:42ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652022-05-011410.3389/fnagi.2022.842549842549Interleaved Pro/Anti-saccade Behavior Across the LifespanRachel Yep0Matthew L. Smorenburg1Heidi C. Riek2Olivia G. Calancie3Ryan H. Kirkpatrick4Ryan H. Kirkpatrick5Julia E. Perkins6Jeff Huang7Brian C. Coe8Donald C. Brien9Douglas P. Munoz10Douglas P. Munoz11Douglas P. Munoz12Centre for Neuroscience Studies, Queen’s University, Kingston, ON, CanadaCentre for Neuroscience Studies, Queen’s University, Kingston, ON, CanadaCentre for Neuroscience Studies, Queen’s University, Kingston, ON, CanadaCentre for Neuroscience Studies, Queen’s University, Kingston, ON, CanadaCentre for Neuroscience Studies, Queen’s University, Kingston, ON, CanadaDepartment of Medicine, Queen’s University, Kingston, ON, CanadaCentre for Neuroscience Studies, Queen’s University, Kingston, ON, CanadaCentre for Neuroscience Studies, Queen’s University, Kingston, ON, CanadaCentre for Neuroscience Studies, Queen’s University, Kingston, ON, CanadaCentre for Neuroscience Studies, Queen’s University, Kingston, ON, CanadaCentre for Neuroscience Studies, Queen’s University, Kingston, ON, CanadaDepartment of Medicine, Queen’s University, Kingston, ON, CanadaDepartment of Biomedical and Molecular Sciences, Queen’s University, Kingston, ON, CanadaThe capacity for inhibitory control is an important cognitive process that undergoes dynamic changes over the course of the lifespan. Robust characterization of this trajectory, considering age continuously and using flexible modeling techniques, is critical to advance our understanding of the neural mechanisms that differ in healthy aging and neurological disease. The interleaved pro/anti-saccade task (IPAST), in which pro- and anti-saccade trials are randomly interleaved within a block, provides a simple and sensitive means of assessing the neural circuitry underlying inhibitory control. We utilized IPAST data collected from a large cross-sectional cohort of normative participants (n = 604, 5–93 years of age), standardized pre-processing protocols, generalized additive modeling, and change point analysis to investigate the effect of age on saccade behavior and identify significant periods of change throughout the lifespan. Maturation of IPAST measures occurred throughout adolescence, while subsequent decline began as early as the mid-20s and continued into old age. Considering pro-saccade correct responses and anti-saccade direction errors made at express (short) and regular (long) latencies was crucial in differentiating developmental and aging processes. We additionally characterized the effect of age on voluntary override time, a novel measure describing the time at which voluntary processes begin to overcome automated processes on anti-saccade trials. Drawing on converging animal neurophysiology, human neuroimaging, and computational modeling literature, we propose potential frontal-parietal and frontal-striatal mechanisms that may mediate the behavioral changes revealed in our analysis. We liken the models presented here to “cognitive growth curves” which have important implications for improved detection of neurological disease states that emerge during vulnerable windows of developing and aging.https://www.frontiersin.org/articles/10.3389/fnagi.2022.842549/fullinhibitory controlanti-saccadeinterleavedlifespanchange point analysis |
| spellingShingle | Rachel Yep Matthew L. Smorenburg Heidi C. Riek Olivia G. Calancie Ryan H. Kirkpatrick Ryan H. Kirkpatrick Julia E. Perkins Jeff Huang Brian C. Coe Donald C. Brien Douglas P. Munoz Douglas P. Munoz Douglas P. Munoz Interleaved Pro/Anti-saccade Behavior Across the Lifespan Frontiers in Aging Neuroscience inhibitory control anti-saccade interleaved lifespan change point analysis |
| title | Interleaved Pro/Anti-saccade Behavior Across the Lifespan |
| title_full | Interleaved Pro/Anti-saccade Behavior Across the Lifespan |
| title_fullStr | Interleaved Pro/Anti-saccade Behavior Across the Lifespan |
| title_full_unstemmed | Interleaved Pro/Anti-saccade Behavior Across the Lifespan |
| title_short | Interleaved Pro/Anti-saccade Behavior Across the Lifespan |
| title_sort | interleaved pro anti saccade behavior across the lifespan |
| topic | inhibitory control anti-saccade interleaved lifespan change point analysis |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2022.842549/full |
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