A 10-year study reveals clinical and laboratory evidence for the ‘semi-invasive’ properties of chronic pulmonary aspergillosis
In recent years, infections caused by Aspergillus sp. have become an emerging focus of clinical microbiology and infectious disease, as the number of patients infected with Aspergillus sp. has increased markedly. Although chronic pulmonary aspergillosis (CPA) is considered a ‘semi-invasive’ or ‘inte...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2016-01-01
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| Series: | Emerging Microbes and Infections |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1038/emi.2016.31 |
| _version_ | 1797679081071837184 |
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| author | Jasper Fuk-Woo Chan Susanna Kar-Pui Lau Sally Cheuk-Ying Wong Kelvin Kai-Wang To Simon Yung-Chun So Sally Sau-Man Leung Siu-Mang Chan Chiu-Mei Pang Chenlu Xiao Ivan Fan-Ngai Hung Vincent Chi-Chung Cheng Kwok-Yung Yuen Patrick Chiu-Yat Woo |
| author_facet | Jasper Fuk-Woo Chan Susanna Kar-Pui Lau Sally Cheuk-Ying Wong Kelvin Kai-Wang To Simon Yung-Chun So Sally Sau-Man Leung Siu-Mang Chan Chiu-Mei Pang Chenlu Xiao Ivan Fan-Ngai Hung Vincent Chi-Chung Cheng Kwok-Yung Yuen Patrick Chiu-Yat Woo |
| author_sort | Jasper Fuk-Woo Chan |
| collection | DOAJ |
| description | In recent years, infections caused by Aspergillus sp. have become an emerging focus of clinical microbiology and infectious disease, as the number of patients infected with Aspergillus sp. has increased markedly. Although chronic pulmonary aspergillosis (CPA) is considered a ‘semi-invasive’ or ‘intermediate’ disease, little data are available for the direct comparison of CPA with invasive pulmonary aspergillosis (IPA) and pulmonary aspergilloma (PA) to quantify invasiveness. In this study, we compared the characteristics of CPA with those of IPA and PA among hospitalized patients over a 10-year period. A total of 29, 51 and 31 cases of CPA, IPA and PA, respectively, were included. An increasing trend in galactomannan antigen seropositivity rate from PA (24.1%) to CPA (35.7%) to IPA (54.9%) and an opposite trend for anti-Aspergillus antibody (PA (71.0%) to CPA (45.8%) to IPA (7.1%)) were observed. Eight percent of CPA patients were infected with more than one Aspergillus sp. The survival rate of the CPA group also fell between the survival rate of PA and IPA, confirming the intermediate severity of CPA. The survival rate of the CPA group became significantly higher than that of the IPA group from day 180 onwards until 2 years after admission (P<0.05). The survival rate of the CPA group remained lower than that of the PA group from day 30 onwards until 2 years after admission. Poor prognostic factors for CPA included older age (P=0.019), higher total leukocyte count (P=0.011) and higher neutrophil count (P=0.012) on admission. This study provided clinical and laboratory evidence for the semi-invasive properties of CPA.Emerging Microbes and Infections (2016) 5, e37; doi:10.1038/emi.2016.31; published online 20 April 2016 |
| first_indexed | 2024-03-11T23:09:15Z |
| format | Article |
| id | doaj.art-3928aec509a146208394727ec49605bf |
| institution | Directory Open Access Journal |
| issn | 2222-1751 |
| language | English |
| last_indexed | 2024-03-11T23:09:15Z |
| publishDate | 2016-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Emerging Microbes and Infections |
| spelling | doaj.art-3928aec509a146208394727ec49605bf2023-09-21T12:27:55ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512016-01-01511710.1038/emi.2016.31A 10-year study reveals clinical and laboratory evidence for the ‘semi-invasive’ properties of chronic pulmonary aspergillosisJasper Fuk-Woo Chan0Susanna Kar-Pui Lau1Sally Cheuk-Ying Wong2Kelvin Kai-Wang To3Simon Yung-Chun So4Sally Sau-Man Leung5Siu-Mang Chan6Chiu-Mei Pang7Chenlu Xiao8Ivan Fan-Ngai Hung9Vincent Chi-Chung Cheng10Kwok-Yung Yuen11Patrick Chiu-Yat Woo12State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, ChinaState Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, ChinaDepartment of Microbiology, The University of Hong Kong, Hong Kong, ChinaState Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, ChinaDepartment of Microbiology, The University of Hong Kong, Hong Kong, ChinaDepartment of Microbiology, The University of Hong Kong, Hong Kong, ChinaDepartment of Microbiology, The University of Hong Kong, Hong Kong, ChinaDepartment of Microbiology, The University of Hong Kong, Hong Kong, ChinaDepartment of Microbiology, The University of Hong Kong, Hong Kong, ChinaResearch Centre of Infection and Immunology, The University of Hong Kong, Hong Kong, ChinaDepartment of Microbiology, The University of Hong Kong, Hong Kong, ChinaState Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, ChinaState Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, ChinaIn recent years, infections caused by Aspergillus sp. have become an emerging focus of clinical microbiology and infectious disease, as the number of patients infected with Aspergillus sp. has increased markedly. Although chronic pulmonary aspergillosis (CPA) is considered a ‘semi-invasive’ or ‘intermediate’ disease, little data are available for the direct comparison of CPA with invasive pulmonary aspergillosis (IPA) and pulmonary aspergilloma (PA) to quantify invasiveness. In this study, we compared the characteristics of CPA with those of IPA and PA among hospitalized patients over a 10-year period. A total of 29, 51 and 31 cases of CPA, IPA and PA, respectively, were included. An increasing trend in galactomannan antigen seropositivity rate from PA (24.1%) to CPA (35.7%) to IPA (54.9%) and an opposite trend for anti-Aspergillus antibody (PA (71.0%) to CPA (45.8%) to IPA (7.1%)) were observed. Eight percent of CPA patients were infected with more than one Aspergillus sp. The survival rate of the CPA group also fell between the survival rate of PA and IPA, confirming the intermediate severity of CPA. The survival rate of the CPA group became significantly higher than that of the IPA group from day 180 onwards until 2 years after admission (P<0.05). The survival rate of the CPA group remained lower than that of the PA group from day 30 onwards until 2 years after admission. Poor prognostic factors for CPA included older age (P=0.019), higher total leukocyte count (P=0.011) and higher neutrophil count (P=0.012) on admission. This study provided clinical and laboratory evidence for the semi-invasive properties of CPA.Emerging Microbes and Infections (2016) 5, e37; doi:10.1038/emi.2016.31; published online 20 April 2016https://www.tandfonline.com/doi/10.1038/emi.2016.31aspergillomaaspergillosischronicinvasivepulmonary |
| spellingShingle | Jasper Fuk-Woo Chan Susanna Kar-Pui Lau Sally Cheuk-Ying Wong Kelvin Kai-Wang To Simon Yung-Chun So Sally Sau-Man Leung Siu-Mang Chan Chiu-Mei Pang Chenlu Xiao Ivan Fan-Ngai Hung Vincent Chi-Chung Cheng Kwok-Yung Yuen Patrick Chiu-Yat Woo A 10-year study reveals clinical and laboratory evidence for the ‘semi-invasive’ properties of chronic pulmonary aspergillosis Emerging Microbes and Infections aspergilloma aspergillosis chronic invasive pulmonary |
| title | A 10-year study reveals clinical and laboratory evidence for the ‘semi-invasive’ properties of chronic pulmonary aspergillosis |
| title_full | A 10-year study reveals clinical and laboratory evidence for the ‘semi-invasive’ properties of chronic pulmonary aspergillosis |
| title_fullStr | A 10-year study reveals clinical and laboratory evidence for the ‘semi-invasive’ properties of chronic pulmonary aspergillosis |
| title_full_unstemmed | A 10-year study reveals clinical and laboratory evidence for the ‘semi-invasive’ properties of chronic pulmonary aspergillosis |
| title_short | A 10-year study reveals clinical and laboratory evidence for the ‘semi-invasive’ properties of chronic pulmonary aspergillosis |
| title_sort | 10 year study reveals clinical and laboratory evidence for the semi invasive properties of chronic pulmonary aspergillosis |
| topic | aspergilloma aspergillosis chronic invasive pulmonary |
| url | https://www.tandfonline.com/doi/10.1038/emi.2016.31 |
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