A comparative study on sedative and cardiorespiratory effects of clonidine and dexmedetomidine added to ropivacaine in supraclavicular brachial plexus block in upper extremity surgery
Background: Supraclavicular brachial plexus block is widely used peripheral nerve block technique used for surgery of the upper extremity. Several drugs have been used with local anesthetic as adjuvants for rapid, dense, and prolonged analgesia. Aims and Objectives: The aims and objectives of the...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Manipal College of Medical Sciences, Pokhara
2023-12-01
|
| Series: | Asian Journal of Medical Sciences |
| Subjects: | |
| Online Access: | https://www.nepjol.info/index.php/AJMS/article/view/58483 |
| _version_ | 1797435100323905536 |
|---|---|
| author | Anamitra Mandal Sourav Naiya Sarbari Swaika Swarup Datta Swapnadeep Sengupta |
| author_facet | Anamitra Mandal Sourav Naiya Sarbari Swaika Swarup Datta Swapnadeep Sengupta |
| author_sort | Anamitra Mandal |
| collection | DOAJ |
| description | Background: Supraclavicular brachial plexus block is widely used peripheral nerve block technique used for surgery of the upper extremity. Several drugs have been used with local anesthetic as adjuvants for rapid, dense, and prolonged analgesia.
Aims and Objectives: The aims and objectives of the study are to compare the degree of sedation and cardiorespiratory effects of clonidine and dexmedetomidine added to ropivacaine in supraclavicular brachial plexus block.
Materials and Methods: A double-blinded comparative study was done on eighty patients who were randomly allocated equally into two groups and received clonidine and dexmedetomidine added to ropivacaine 0.5%. Intraoperative degree of sedation and cardiorespiratory parameters were monitored in regular intervals and compared to find difference.
Results: Heart rate was consistently lower with dexmedetomidine. Systolic, diastolic, and mean arterial pressures (MAPs) were comparable in both groups at all time points except at 45 min when diastolic and MAP were lower with dexmedetomidine and it was statistically significant. Sedation score in Group D was higher except at 5 min and difference was statistically significant. All patients in both groups were sedated and easily arousable. There was statistically significant difference in peroperative oxygen saturation between the groups although it was clinically not significant.
Conclusion: There was more hemodynamic effect of dexmedetomidine than clonidine but these effects can be managed by medication easily. In addition to this, it was found that dexmedetomidine provides conscious sedation without any respiratory depression. Comparing the risk and benefit dexmedetomidine can be used with local anesthetic in supraclavicular brachial plexus block in upper extremity surgery. |
| first_indexed | 2024-03-09T10:42:23Z |
| format | Article |
| id | doaj.art-392926fc392e48afb07442d416a8d7d4 |
| institution | Directory Open Access Journal |
| issn | 2467-9100 2091-0576 |
| language | English |
| last_indexed | 2024-03-09T10:42:23Z |
| publishDate | 2023-12-01 |
| publisher | Manipal College of Medical Sciences, Pokhara |
| record_format | Article |
| series | Asian Journal of Medical Sciences |
| spelling | doaj.art-392926fc392e48afb07442d416a8d7d42023-12-01T13:14:19ZengManipal College of Medical Sciences, PokharaAsian Journal of Medical Sciences2467-91002091-05762023-12-0114122126https://doi.org/10.3126/ajms.v14i12.58483A comparative study on sedative and cardiorespiratory effects of clonidine and dexmedetomidine added to ropivacaine in supraclavicular brachial plexus block in upper extremity surgeryAnamitra Mandal 0https://orcid.org/0009-0001-7701-2056Sourav Naiya 1https://orcid.org/0009-0001-7559-024XSarbari Swaika 2https://orcid.org/0000-0002-0525-8460Swarup Datta 3https://orcid.org/0000-0002-1493-7270Swapnadeep Sengupta 4https://orcid.org/0000-0001-8594-4315Assistant Professor, Department of Anesthesiology, Deben Mahata Government Medical College and Hospital, Purulia, West Bengal, IndiaAssistant Professor, Department of Community Medicine, Deben Mahata Government Medical College and Hospital, Purulia, West Bengal, India Professor, Department of Anesthesiology, IPGME&R, Kolkata, India Associate Professor, Department of Anesthesiology, Bankura Sammilani Medical College and Hospital, Bankura, West Bengal, India Assistant Professor, Department of Anesthesiology, Calcutta National Medical College and Hospital, Kolkata, West Bengal, India Background: Supraclavicular brachial plexus block is widely used peripheral nerve block technique used for surgery of the upper extremity. Several drugs have been used with local anesthetic as adjuvants for rapid, dense, and prolonged analgesia. Aims and Objectives: The aims and objectives of the study are to compare the degree of sedation and cardiorespiratory effects of clonidine and dexmedetomidine added to ropivacaine in supraclavicular brachial plexus block. Materials and Methods: A double-blinded comparative study was done on eighty patients who were randomly allocated equally into two groups and received clonidine and dexmedetomidine added to ropivacaine 0.5%. Intraoperative degree of sedation and cardiorespiratory parameters were monitored in regular intervals and compared to find difference. Results: Heart rate was consistently lower with dexmedetomidine. Systolic, diastolic, and mean arterial pressures (MAPs) were comparable in both groups at all time points except at 45 min when diastolic and MAP were lower with dexmedetomidine and it was statistically significant. Sedation score in Group D was higher except at 5 min and difference was statistically significant. All patients in both groups were sedated and easily arousable. There was statistically significant difference in peroperative oxygen saturation between the groups although it was clinically not significant. Conclusion: There was more hemodynamic effect of dexmedetomidine than clonidine but these effects can be managed by medication easily. In addition to this, it was found that dexmedetomidine provides conscious sedation without any respiratory depression. Comparing the risk and benefit dexmedetomidine can be used with local anesthetic in supraclavicular brachial plexus block in upper extremity surgery.https://www.nepjol.info/index.php/AJMS/article/view/58483anesthetics; blood pressure; brachial plexus block; clonidine dexmedetomidine; heart rate; oxygen saturation; ropivacaine |
| spellingShingle | Anamitra Mandal Sourav Naiya Sarbari Swaika Swarup Datta Swapnadeep Sengupta A comparative study on sedative and cardiorespiratory effects of clonidine and dexmedetomidine added to ropivacaine in supraclavicular brachial plexus block in upper extremity surgery Asian Journal of Medical Sciences anesthetics; blood pressure; brachial plexus block; clonidine dexmedetomidine; heart rate; oxygen saturation; ropivacaine |
| title | A comparative study on sedative and cardiorespiratory effects of clonidine and dexmedetomidine added to ropivacaine in supraclavicular brachial plexus block in upper extremity surgery |
| title_full | A comparative study on sedative and cardiorespiratory effects of clonidine and dexmedetomidine added to ropivacaine in supraclavicular brachial plexus block in upper extremity surgery |
| title_fullStr | A comparative study on sedative and cardiorespiratory effects of clonidine and dexmedetomidine added to ropivacaine in supraclavicular brachial plexus block in upper extremity surgery |
| title_full_unstemmed | A comparative study on sedative and cardiorespiratory effects of clonidine and dexmedetomidine added to ropivacaine in supraclavicular brachial plexus block in upper extremity surgery |
| title_short | A comparative study on sedative and cardiorespiratory effects of clonidine and dexmedetomidine added to ropivacaine in supraclavicular brachial plexus block in upper extremity surgery |
| title_sort | comparative study on sedative and cardiorespiratory effects of clonidine and dexmedetomidine added to ropivacaine in supraclavicular brachial plexus block in upper extremity surgery |
| topic | anesthetics; blood pressure; brachial plexus block; clonidine dexmedetomidine; heart rate; oxygen saturation; ropivacaine |
| url | https://www.nepjol.info/index.php/AJMS/article/view/58483 |
| work_keys_str_mv | AT anamitramandal acomparativestudyonsedativeandcardiorespiratoryeffectsofclonidineanddexmedetomidineaddedtoropivacaineinsupraclavicularbrachialplexusblockinupperextremitysurgery AT souravnaiya acomparativestudyonsedativeandcardiorespiratoryeffectsofclonidineanddexmedetomidineaddedtoropivacaineinsupraclavicularbrachialplexusblockinupperextremitysurgery AT sarbariswaika acomparativestudyonsedativeandcardiorespiratoryeffectsofclonidineanddexmedetomidineaddedtoropivacaineinsupraclavicularbrachialplexusblockinupperextremitysurgery AT swarupdatta acomparativestudyonsedativeandcardiorespiratoryeffectsofclonidineanddexmedetomidineaddedtoropivacaineinsupraclavicularbrachialplexusblockinupperextremitysurgery AT swapnadeepsengupta acomparativestudyonsedativeandcardiorespiratoryeffectsofclonidineanddexmedetomidineaddedtoropivacaineinsupraclavicularbrachialplexusblockinupperextremitysurgery AT anamitramandal comparativestudyonsedativeandcardiorespiratoryeffectsofclonidineanddexmedetomidineaddedtoropivacaineinsupraclavicularbrachialplexusblockinupperextremitysurgery AT souravnaiya comparativestudyonsedativeandcardiorespiratoryeffectsofclonidineanddexmedetomidineaddedtoropivacaineinsupraclavicularbrachialplexusblockinupperextremitysurgery AT sarbariswaika comparativestudyonsedativeandcardiorespiratoryeffectsofclonidineanddexmedetomidineaddedtoropivacaineinsupraclavicularbrachialplexusblockinupperextremitysurgery AT swarupdatta comparativestudyonsedativeandcardiorespiratoryeffectsofclonidineanddexmedetomidineaddedtoropivacaineinsupraclavicularbrachialplexusblockinupperextremitysurgery AT swapnadeepsengupta comparativestudyonsedativeandcardiorespiratoryeffectsofclonidineanddexmedetomidineaddedtoropivacaineinsupraclavicularbrachialplexusblockinupperextremitysurgery |