Cellular mechanisms underlying the inhibitory effect of flufenamic acid on chloride secretion in human intestinal epithelial cells

Cellular mechanisms underlying the inhibitory effect of flufenamic acid on chloride secretion in human intestinal epithelial cells

Intestinal Cl− secretion is involved in the pathogenesis of secretory diarrheas including cholera. We recently demonstrated that flufenamic acid (FFA) suppressed Vibrio cholerae El Tor variant-induced intestinal fluid secretion via mechanisms involving AMPK activation and NF-κB-suppression. The pres...

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Bibliographic Details
Main Authors: Pawin Pongkorpsakol, Chantapol Yimnual, Varanuj Chatsudthipong, Vatcharin Rukachaisirikul, Chatchai Muanprasat
Format: Article
Language:English
Published: Elsevier 2017-06-01
Series:Journal of Pharmacological Sciences
Subjects:
Flufenamic acid
Cholera
Diarrhea
Chloride channel
Chloride secretion
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861317300853

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