Sarcoma Metabolomics: Current Horizons and Future Perspectives
The vast array of metabolic adaptations that cancer cells are capable of assuming, not only support their biosynthetic activity, but also fulfill their bioenergetic demands and keep their intracellular reduction–oxidation (redox) balance. Spotlight has recently been placed on the energy metabolism r...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/10/6/1432 |
| _version_ | 1797530924134432768 |
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| author | Miguel Esperança-Martins Isabel Fernandes Joaquim Soares do Brito Daniela Macedo Hugo Vasques Teresa Serafim Luís Costa Sérgio Dias |
| author_facet | Miguel Esperança-Martins Isabel Fernandes Joaquim Soares do Brito Daniela Macedo Hugo Vasques Teresa Serafim Luís Costa Sérgio Dias |
| author_sort | Miguel Esperança-Martins |
| collection | DOAJ |
| description | The vast array of metabolic adaptations that cancer cells are capable of assuming, not only support their biosynthetic activity, but also fulfill their bioenergetic demands and keep their intracellular reduction–oxidation (redox) balance. Spotlight has recently been placed on the energy metabolism reprogramming strategies employed by cancer cells to proliferate. Knowledge regarding soft tissue and bone sarcomas metabolome is relatively sparse. Further characterization of sarcoma metabolic landscape may pave the way for diagnostic refinement and new therapeutic target identification, with benefit to sarcoma patients. This review covers the state-of-the-art knowledge on cancer metabolomics and explores in detail the most recent evidence on soft tissue and bone sarcoma metabolomics. |
| first_indexed | 2024-03-10T10:36:57Z |
| format | Article |
| id | doaj.art-392aa38d19e841988f9e90f0f6e1ec0b |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T10:36:57Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-392aa38d19e841988f9e90f0f6e1ec0b2023-11-21T23:14:08ZengMDPI AGCells2073-44092021-06-01106143210.3390/cells10061432Sarcoma Metabolomics: Current Horizons and Future PerspectivesMiguel Esperança-Martins0Isabel Fernandes1Joaquim Soares do Brito2Daniela Macedo3Hugo Vasques4Teresa Serafim5Luís Costa6Sérgio Dias7Centro Hospitalar Universitário Lisboa Norte, Medical Oncology Department, Hospital Santa Maria, 1649-028 Lisboa, PortugalCentro Hospitalar Universitário Lisboa Norte, Medical Oncology Department, Hospital Santa Maria, 1649-028 Lisboa, PortugalFaculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, PortugalMedical Oncology Department, Hospital Lusíadas Lisboa, 1500-458 Lisboa, PortugalFaculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, PortugalVascular Biology & Cancer Microenvironment Lab, Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, PortugalCentro Hospitalar Universitário Lisboa Norte, Medical Oncology Department, Hospital Santa Maria, 1649-028 Lisboa, PortugalVascular Biology & Cancer Microenvironment Lab, Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, PortugalThe vast array of metabolic adaptations that cancer cells are capable of assuming, not only support their biosynthetic activity, but also fulfill their bioenergetic demands and keep their intracellular reduction–oxidation (redox) balance. Spotlight has recently been placed on the energy metabolism reprogramming strategies employed by cancer cells to proliferate. Knowledge regarding soft tissue and bone sarcomas metabolome is relatively sparse. Further characterization of sarcoma metabolic landscape may pave the way for diagnostic refinement and new therapeutic target identification, with benefit to sarcoma patients. This review covers the state-of-the-art knowledge on cancer metabolomics and explores in detail the most recent evidence on soft tissue and bone sarcoma metabolomics.https://www.mdpi.com/2073-4409/10/6/1432sarcomasoft tissue sarcomabone sarcomagastrointestinal stromal tumormetabolomicsmetabolism |
| spellingShingle | Miguel Esperança-Martins Isabel Fernandes Joaquim Soares do Brito Daniela Macedo Hugo Vasques Teresa Serafim Luís Costa Sérgio Dias Sarcoma Metabolomics: Current Horizons and Future Perspectives Cells sarcoma soft tissue sarcoma bone sarcoma gastrointestinal stromal tumor metabolomics metabolism |
| title | Sarcoma Metabolomics: Current Horizons and Future Perspectives |
| title_full | Sarcoma Metabolomics: Current Horizons and Future Perspectives |
| title_fullStr | Sarcoma Metabolomics: Current Horizons and Future Perspectives |
| title_full_unstemmed | Sarcoma Metabolomics: Current Horizons and Future Perspectives |
| title_short | Sarcoma Metabolomics: Current Horizons and Future Perspectives |
| title_sort | sarcoma metabolomics current horizons and future perspectives |
| topic | sarcoma soft tissue sarcoma bone sarcoma gastrointestinal stromal tumor metabolomics metabolism |
| url | https://www.mdpi.com/2073-4409/10/6/1432 |
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