Nitrido Technetium-99 m Core in Radiopharmaceutical Applications: Four Decades of Research
The knowledge on element 43 (Tc) of the periodic table, built over the years through the contributions given by the close relationship between chemistry and nuclear medicine, allowed the development of new and increasingly effective radiopharmaceuticals useful both as perfusion and target specific i...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-12-01
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| Series: | Inorganics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2304-6740/8/1/3 |
| _version_ | 1818514070726246400 |
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| author | Cristina Bolzati Alessandro Dolmella |
| author_facet | Cristina Bolzati Alessandro Dolmella |
| author_sort | Cristina Bolzati |
| collection | DOAJ |
| description | The knowledge on element 43 (Tc) of the periodic table, built over the years through the contributions given by the close relationship between chemistry and nuclear medicine, allowed the development of new and increasingly effective radiopharmaceuticals useful both as perfusion and target specific imaging agents for SPECT (single photon emission tomography). Among the manifold Tc-compounds, Tc(V) nitrido complexes played a relevant role in the search for new technetium-99m radiopharmaceuticals, providing efficient labeling procedures that can be conveniently exploited for the design and synthesis of agents, also incorporating small organic molecules or peptides having defined structural features. With this work, we present an overview of four decades of research on the chemistry and on the nuclear medicine applications of Tc(V) nitrido complexes. |
| first_indexed | 2024-12-11T00:10:12Z |
| format | Article |
| id | doaj.art-392b3137ed1b4d39b18a7d8bd2688aad |
| institution | Directory Open Access Journal |
| issn | 2304-6740 |
| language | English |
| last_indexed | 2024-12-11T00:10:12Z |
| publishDate | 2019-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Inorganics |
| spelling | doaj.art-392b3137ed1b4d39b18a7d8bd2688aad2022-12-22T01:28:09ZengMDPI AGInorganics2304-67402019-12-0181310.3390/inorganics8010003inorganics8010003Nitrido Technetium-99 m Core in Radiopharmaceutical Applications: Four Decades of ResearchCristina Bolzati0Alessandro Dolmella1Institute of Condensed Matter Chemistry and Technologies for Energy ICMATE-CNR, Corso Stati Uniti, 4, I-35127 Padova, ItalyDepartment of Pharmaceutical and Pharmacological Sciences, University of Padova, Via Marzolo, 5, I-35131 Padova, ItalyThe knowledge on element 43 (Tc) of the periodic table, built over the years through the contributions given by the close relationship between chemistry and nuclear medicine, allowed the development of new and increasingly effective radiopharmaceuticals useful both as perfusion and target specific imaging agents for SPECT (single photon emission tomography). Among the manifold Tc-compounds, Tc(V) nitrido complexes played a relevant role in the search for new technetium-99m radiopharmaceuticals, providing efficient labeling procedures that can be conveniently exploited for the design and synthesis of agents, also incorporating small organic molecules or peptides having defined structural features. With this work, we present an overview of four decades of research on the chemistry and on the nuclear medicine applications of Tc(V) nitrido complexes.https://www.mdpi.com/2304-6740/8/1/3nitrido complexestechnetium-99mradiopharmaceuticalsimagingtarget specific compounds |
| spellingShingle | Cristina Bolzati Alessandro Dolmella Nitrido Technetium-99 m Core in Radiopharmaceutical Applications: Four Decades of Research Inorganics nitrido complexes technetium-99m radiopharmaceuticals imaging target specific compounds |
| title | Nitrido Technetium-99 m Core in Radiopharmaceutical Applications: Four Decades of Research |
| title_full | Nitrido Technetium-99 m Core in Radiopharmaceutical Applications: Four Decades of Research |
| title_fullStr | Nitrido Technetium-99 m Core in Radiopharmaceutical Applications: Four Decades of Research |
| title_full_unstemmed | Nitrido Technetium-99 m Core in Radiopharmaceutical Applications: Four Decades of Research |
| title_short | Nitrido Technetium-99 m Core in Radiopharmaceutical Applications: Four Decades of Research |
| title_sort | nitrido technetium 99 m core in radiopharmaceutical applications four decades of research |
| topic | nitrido complexes technetium-99m radiopharmaceuticals imaging target specific compounds |
| url | https://www.mdpi.com/2304-6740/8/1/3 |
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