Coexistence of lateral and co-tuned inhibitory configurations in cortical networks.
The responses of neurons in sensory cortex depend on the summation of excitatory and inhibitory synaptic inputs. How the excitatory and inhibitory inputs scale with stimulus depends on the network architecture, which ranges from the lateral inhibitory configuration where excitatory inputs are more n...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2011-10-01
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| Series: | PLoS Computational Biology |
| Online Access: | http://europepmc.org/articles/PMC3188483?pdf=render |
| _version_ | 1818413924529209344 |
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| author | Robert B Levy Alex D Reyes |
| author_facet | Robert B Levy Alex D Reyes |
| author_sort | Robert B Levy |
| collection | DOAJ |
| description | The responses of neurons in sensory cortex depend on the summation of excitatory and inhibitory synaptic inputs. How the excitatory and inhibitory inputs scale with stimulus depends on the network architecture, which ranges from the lateral inhibitory configuration where excitatory inputs are more narrowly tuned than inhibitory inputs, to the co-tuned configuration where both are tuned equally. The underlying circuitry that gives rise to lateral inhibition and co-tuning is yet unclear. Using large-scale network simulations with experimentally determined connectivity patterns and simulations with rate models, we show that the spatial extent of the input determined the configuration: there was a smooth transition from lateral inhibition with narrow input to co-tuning with broad input. The transition from lateral inhibition to co-tuning was accompanied by shifts in overall gain (reduced), output firing pattern (from tonic to phasic) and rate-level functions (from non-monotonic to monotonically increasing). The results suggest that a single cortical network architecture could account for the extended range of experimentally observed response types between the extremes of lateral inhibitory versus co-tuned configurations. |
| first_indexed | 2024-12-14T11:10:56Z |
| format | Article |
| id | doaj.art-392bceee9b954496a5798547638c6148 |
| institution | Directory Open Access Journal |
| issn | 1553-734X 1553-7358 |
| language | English |
| last_indexed | 2024-12-14T11:10:56Z |
| publishDate | 2011-10-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Computational Biology |
| spelling | doaj.art-392bceee9b954496a5798547638c61482022-12-21T23:04:17ZengPublic Library of Science (PLoS)PLoS Computational Biology1553-734X1553-73582011-10-01710e100216110.1371/journal.pcbi.1002161Coexistence of lateral and co-tuned inhibitory configurations in cortical networks.Robert B LevyAlex D ReyesThe responses of neurons in sensory cortex depend on the summation of excitatory and inhibitory synaptic inputs. How the excitatory and inhibitory inputs scale with stimulus depends on the network architecture, which ranges from the lateral inhibitory configuration where excitatory inputs are more narrowly tuned than inhibitory inputs, to the co-tuned configuration where both are tuned equally. The underlying circuitry that gives rise to lateral inhibition and co-tuning is yet unclear. Using large-scale network simulations with experimentally determined connectivity patterns and simulations with rate models, we show that the spatial extent of the input determined the configuration: there was a smooth transition from lateral inhibition with narrow input to co-tuning with broad input. The transition from lateral inhibition to co-tuning was accompanied by shifts in overall gain (reduced), output firing pattern (from tonic to phasic) and rate-level functions (from non-monotonic to monotonically increasing). The results suggest that a single cortical network architecture could account for the extended range of experimentally observed response types between the extremes of lateral inhibitory versus co-tuned configurations.http://europepmc.org/articles/PMC3188483?pdf=render |
| spellingShingle | Robert B Levy Alex D Reyes Coexistence of lateral and co-tuned inhibitory configurations in cortical networks. PLoS Computational Biology |
| title | Coexistence of lateral and co-tuned inhibitory configurations in cortical networks. |
| title_full | Coexistence of lateral and co-tuned inhibitory configurations in cortical networks. |
| title_fullStr | Coexistence of lateral and co-tuned inhibitory configurations in cortical networks. |
| title_full_unstemmed | Coexistence of lateral and co-tuned inhibitory configurations in cortical networks. |
| title_short | Coexistence of lateral and co-tuned inhibitory configurations in cortical networks. |
| title_sort | coexistence of lateral and co tuned inhibitory configurations in cortical networks |
| url | http://europepmc.org/articles/PMC3188483?pdf=render |
| work_keys_str_mv | AT robertblevy coexistenceoflateralandcotunedinhibitoryconfigurationsincorticalnetworks AT alexdreyes coexistenceoflateralandcotunedinhibitoryconfigurationsincorticalnetworks |