Importance of <i>Aspergillus</i>-Specific Antibody Screening for Diagnosis of Chronic Pulmonary Aspergillosis after Tuberculosis Treatment: A Prospective Follow-Up Study in Ghana
Chronic pulmonary aspergillosis (CPA) often occurs in patients that have been previously treated for pulmonary tuberculosis (PTB). A limited number of studies have looked at the development of CPA at different times following the completion of a PTB treatment course. This prospective longitudinal st...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-12-01
|
| Series: | Journal of Fungi |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2309-608X/9/1/26 |
| _version_ | 1797440255257739264 |
|---|---|
| author | Bright K. Ocansey Benjamin Otoo Hafisatu Gbadamosi Jane S. Afriyie-Mensah Japheth A. Opintan Chris Kosmidis David W. Denning |
| author_facet | Bright K. Ocansey Benjamin Otoo Hafisatu Gbadamosi Jane S. Afriyie-Mensah Japheth A. Opintan Chris Kosmidis David W. Denning |
| author_sort | Bright K. Ocansey |
| collection | DOAJ |
| description | Chronic pulmonary aspergillosis (CPA) often occurs in patients that have been previously treated for pulmonary tuberculosis (PTB). A limited number of studies have looked at the development of CPA at different times following the completion of a PTB treatment course. This prospective longitudinal study aimed to determine the incidence of CPA at two timepoints, at the end of the PTB treatment (T<sub>1</sub>) and six months post-treatment (T<sub>2</sub>). Patients with confirmed PTB from a previous study who were placed on anti-TB medication were followed up and screened for CPA at T<sub>1</sub> and T<sub>2</sub> by assessing their symptoms, evaluating their quality of life, and screening them for <i>Aspergillus</i> infection by performing antibody testing and cultures. CPA was defined by the Global Action for Fungal Infections (GAFFI) diagnostic algorithm. Forty-one patients were enrolled, of whom thirty-three patients (80%) and twenty-eight patients (68%) were resurveyed at T<sub>1</sub> and T<sub>2,</sub> respectively. The rate of new CPA was 3.3% (1/33) and 7.4% (2/27) at T<sub>1</sub> and T<sub>2</sub>, respectively, with an overall incidence of 10.7% (3/28) among the patients at both T<sub>1</sub> and T<sub>2</sub>. A positive <i>Aspergillus</i>-specific antibody test was an indicator for CPA in all three patients. <i>Aspergillus</i>-specific antibody screening during and after the end of an anti-TB treatment regimen may be important for early detection of CPA in high-PTB-burden settings. |
| first_indexed | 2024-03-09T12:04:32Z |
| format | Article |
| id | doaj.art-392bd5a4555e4ddabb9b03c8cc91bcd0 |
| institution | Directory Open Access Journal |
| issn | 2309-608X |
| language | English |
| last_indexed | 2024-03-09T12:04:32Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Fungi |
| spelling | doaj.art-392bd5a4555e4ddabb9b03c8cc91bcd02023-11-30T22:59:19ZengMDPI AGJournal of Fungi2309-608X2022-12-01912610.3390/jof9010026Importance of <i>Aspergillus</i>-Specific Antibody Screening for Diagnosis of Chronic Pulmonary Aspergillosis after Tuberculosis Treatment: A Prospective Follow-Up Study in GhanaBright K. Ocansey0Benjamin Otoo1Hafisatu Gbadamosi2Jane S. Afriyie-Mensah3Japheth A. Opintan4Chris Kosmidis5David W. Denning6Division of Evolution, Infection and Genomics, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9NT, UKDepartment of Bacteriology, University of Wisconsin-Madison, Madison, WI 53706, USARadiology Department, Korle-Bu Teaching Hospital, Accra GA-221-1570, GhanaChest Diseases Unit, Department of Medicine, Korle-Bu Teaching Hospital, Accra GA-221-1570, GhanaDepartment of Medical Microbiology, University of Ghana Medical School, Accra GA-270-4330, GhanaDivision of Evolution, Infection and Genomics, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9NT, UKDivision of Evolution, Infection and Genomics, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9NT, UKChronic pulmonary aspergillosis (CPA) often occurs in patients that have been previously treated for pulmonary tuberculosis (PTB). A limited number of studies have looked at the development of CPA at different times following the completion of a PTB treatment course. This prospective longitudinal study aimed to determine the incidence of CPA at two timepoints, at the end of the PTB treatment (T<sub>1</sub>) and six months post-treatment (T<sub>2</sub>). Patients with confirmed PTB from a previous study who were placed on anti-TB medication were followed up and screened for CPA at T<sub>1</sub> and T<sub>2</sub> by assessing their symptoms, evaluating their quality of life, and screening them for <i>Aspergillus</i> infection by performing antibody testing and cultures. CPA was defined by the Global Action for Fungal Infections (GAFFI) diagnostic algorithm. Forty-one patients were enrolled, of whom thirty-three patients (80%) and twenty-eight patients (68%) were resurveyed at T<sub>1</sub> and T<sub>2,</sub> respectively. The rate of new CPA was 3.3% (1/33) and 7.4% (2/27) at T<sub>1</sub> and T<sub>2</sub>, respectively, with an overall incidence of 10.7% (3/28) among the patients at both T<sub>1</sub> and T<sub>2</sub>. A positive <i>Aspergillus</i>-specific antibody test was an indicator for CPA in all three patients. <i>Aspergillus</i>-specific antibody screening during and after the end of an anti-TB treatment regimen may be important for early detection of CPA in high-PTB-burden settings.https://www.mdpi.com/2309-608X/9/1/26<i>Aspergillus</i> antibodychronic pulmonary aspergillosisGhanatuberculosis |
| spellingShingle | Bright K. Ocansey Benjamin Otoo Hafisatu Gbadamosi Jane S. Afriyie-Mensah Japheth A. Opintan Chris Kosmidis David W. Denning Importance of <i>Aspergillus</i>-Specific Antibody Screening for Diagnosis of Chronic Pulmonary Aspergillosis after Tuberculosis Treatment: A Prospective Follow-Up Study in Ghana Journal of Fungi <i>Aspergillus</i> antibody chronic pulmonary aspergillosis Ghana tuberculosis |
| title | Importance of <i>Aspergillus</i>-Specific Antibody Screening for Diagnosis of Chronic Pulmonary Aspergillosis after Tuberculosis Treatment: A Prospective Follow-Up Study in Ghana |
| title_full | Importance of <i>Aspergillus</i>-Specific Antibody Screening for Diagnosis of Chronic Pulmonary Aspergillosis after Tuberculosis Treatment: A Prospective Follow-Up Study in Ghana |
| title_fullStr | Importance of <i>Aspergillus</i>-Specific Antibody Screening for Diagnosis of Chronic Pulmonary Aspergillosis after Tuberculosis Treatment: A Prospective Follow-Up Study in Ghana |
| title_full_unstemmed | Importance of <i>Aspergillus</i>-Specific Antibody Screening for Diagnosis of Chronic Pulmonary Aspergillosis after Tuberculosis Treatment: A Prospective Follow-Up Study in Ghana |
| title_short | Importance of <i>Aspergillus</i>-Specific Antibody Screening for Diagnosis of Chronic Pulmonary Aspergillosis after Tuberculosis Treatment: A Prospective Follow-Up Study in Ghana |
| title_sort | importance of i aspergillus i specific antibody screening for diagnosis of chronic pulmonary aspergillosis after tuberculosis treatment a prospective follow up study in ghana |
| topic | <i>Aspergillus</i> antibody chronic pulmonary aspergillosis Ghana tuberculosis |
| url | https://www.mdpi.com/2309-608X/9/1/26 |
| work_keys_str_mv | AT brightkocansey importanceofiaspergillusispecificantibodyscreeningfordiagnosisofchronicpulmonaryaspergillosisaftertuberculosistreatmentaprospectivefollowupstudyinghana AT benjaminotoo importanceofiaspergillusispecificantibodyscreeningfordiagnosisofchronicpulmonaryaspergillosisaftertuberculosistreatmentaprospectivefollowupstudyinghana AT hafisatugbadamosi importanceofiaspergillusispecificantibodyscreeningfordiagnosisofchronicpulmonaryaspergillosisaftertuberculosistreatmentaprospectivefollowupstudyinghana AT janesafriyiemensah importanceofiaspergillusispecificantibodyscreeningfordiagnosisofchronicpulmonaryaspergillosisaftertuberculosistreatmentaprospectivefollowupstudyinghana AT japhethaopintan importanceofiaspergillusispecificantibodyscreeningfordiagnosisofchronicpulmonaryaspergillosisaftertuberculosistreatmentaprospectivefollowupstudyinghana AT chriskosmidis importanceofiaspergillusispecificantibodyscreeningfordiagnosisofchronicpulmonaryaspergillosisaftertuberculosistreatmentaprospectivefollowupstudyinghana AT davidwdenning importanceofiaspergillusispecificantibodyscreeningfordiagnosisofchronicpulmonaryaspergillosisaftertuberculosistreatmentaprospectivefollowupstudyinghana |