UPF1—From mRNA Degradation to Human Disorders
Up-frameshift protein 1 (UPF1) plays the role of a vital controller for transcripts, ready to react in the event of an incorrect translation mechanism. It is well known as one of the key elements involved in mRNA decay pathways and participates in transcript and protein quality control in several di...
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| Format: | Article |
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MDPI AG
2023-01-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/12/3/419 |
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| author | Jacek Staszewski Natalia Lazarewicz Julia Konczak Iwona Migdal Ewa Maciaszczyk-Dziubinska |
| author_facet | Jacek Staszewski Natalia Lazarewicz Julia Konczak Iwona Migdal Ewa Maciaszczyk-Dziubinska |
| author_sort | Jacek Staszewski |
| collection | DOAJ |
| description | Up-frameshift protein 1 (UPF1) plays the role of a vital controller for transcripts, ready to react in the event of an incorrect translation mechanism. It is well known as one of the key elements involved in mRNA decay pathways and participates in transcript and protein quality control in several different aspects. Firstly, UPF1 specifically degrades premature termination codon (PTC)-containing products in a nonsense-mediated mRNA decay (NMD)-coupled manner. Additionally, UPF1 can potentially act as an E3 ligase and degrade target proteins independently from mRNA decay pathways. Thus, UPF1 protects cells against the accumulation of misfolded polypeptides. However, this multitasking protein may still hide many of its functions and abilities. In this article, we summarize important discoveries in the context of UPF1, its involvement in various cellular pathways, as well as its structural importance and mutational changes related to the emergence of various pathologies and disease states. Even though the state of knowledge about this protein has significantly increased over the years, there are still many intriguing aspects that remain unresolved. |
| first_indexed | 2024-03-11T09:48:53Z |
| format | Article |
| id | doaj.art-392ce1bc867a40558d624ce66e084b6f |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-11T09:48:53Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-392ce1bc867a40558d624ce66e084b6f2023-11-16T16:21:22ZengMDPI AGCells2073-44092023-01-0112341910.3390/cells12030419UPF1—From mRNA Degradation to Human DisordersJacek Staszewski0Natalia Lazarewicz1Julia Konczak2Iwona Migdal3Ewa Maciaszczyk-Dziubinska4Department of Genetics and Cell Physiology, Faculty of Biological Sciences, University of Wroclaw, 50-328 Wroclaw, PolandDepartment of Genetics and Cell Physiology, Faculty of Biological Sciences, University of Wroclaw, 50-328 Wroclaw, PolandDepartment of Genetics and Cell Physiology, Faculty of Biological Sciences, University of Wroclaw, 50-328 Wroclaw, PolandDepartment of Genetics and Cell Physiology, Faculty of Biological Sciences, University of Wroclaw, 50-328 Wroclaw, PolandDepartment of Genetics and Cell Physiology, Faculty of Biological Sciences, University of Wroclaw, 50-328 Wroclaw, PolandUp-frameshift protein 1 (UPF1) plays the role of a vital controller for transcripts, ready to react in the event of an incorrect translation mechanism. It is well known as one of the key elements involved in mRNA decay pathways and participates in transcript and protein quality control in several different aspects. Firstly, UPF1 specifically degrades premature termination codon (PTC)-containing products in a nonsense-mediated mRNA decay (NMD)-coupled manner. Additionally, UPF1 can potentially act as an E3 ligase and degrade target proteins independently from mRNA decay pathways. Thus, UPF1 protects cells against the accumulation of misfolded polypeptides. However, this multitasking protein may still hide many of its functions and abilities. In this article, we summarize important discoveries in the context of UPF1, its involvement in various cellular pathways, as well as its structural importance and mutational changes related to the emergence of various pathologies and disease states. Even though the state of knowledge about this protein has significantly increased over the years, there are still many intriguing aspects that remain unresolved.https://www.mdpi.com/2073-4409/12/3/419UPF1helicaseE3 ligaseNMDdecay pathwayscancer |
| spellingShingle | Jacek Staszewski Natalia Lazarewicz Julia Konczak Iwona Migdal Ewa Maciaszczyk-Dziubinska UPF1—From mRNA Degradation to Human Disorders Cells UPF1 helicase E3 ligase NMD decay pathways cancer |
| title | UPF1—From mRNA Degradation to Human Disorders |
| title_full | UPF1—From mRNA Degradation to Human Disorders |
| title_fullStr | UPF1—From mRNA Degradation to Human Disorders |
| title_full_unstemmed | UPF1—From mRNA Degradation to Human Disorders |
| title_short | UPF1—From mRNA Degradation to Human Disorders |
| title_sort | upf1 from mrna degradation to human disorders |
| topic | UPF1 helicase E3 ligase NMD decay pathways cancer |
| url | https://www.mdpi.com/2073-4409/12/3/419 |
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