Multicenter study to describe viral etiologies, clinical profiles, and outcomes of hospitalized children with severe acute respiratory infections, Egypt 2022
Abstract In late 2022, severe acute respiratory infections (SARI) surveillance reported an abrupt increase in non-COVID-19 infections among children after three years of drastic reductions. Signals of increased absenteeism due to respiratory symptoms among primary and preparatory school children wer...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-12-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-48814-x |
| _version_ | 1797398000937467904 |
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| author | Amr Kandeel Manal Fahim Ola Deghedy Wael H. Roshdy Mohamed K. Khalifa Rabeh El Shesheny Ahmed Kandeil Saly Wagdy Amel Naguib Salma Afifi Khaled Abdelghaffar |
| author_facet | Amr Kandeel Manal Fahim Ola Deghedy Wael H. Roshdy Mohamed K. Khalifa Rabeh El Shesheny Ahmed Kandeil Saly Wagdy Amel Naguib Salma Afifi Khaled Abdelghaffar |
| author_sort | Amr Kandeel |
| collection | DOAJ |
| description | Abstract In late 2022, severe acute respiratory infections (SARI) surveillance reported an abrupt increase in non-COVID-19 infections among children after three years of drastic reductions. Signals of increased absenteeism due to respiratory symptoms among primary and preparatory school children were detected by Event-Based Surveillance. We conducted a hospital-based survey of children who were admitted with SARI to identify the causative pathogen(s) and estimate the burden of infection. A survey was conducted among children < 16 years in 21 referral hospitals in the three governorates with the highest SARI rates. Patients’ demographics, clinical symptoms, and severity were collected from medical records using a line list. Patients were swabbed and tested for a panel of 33 respiratory pathogens by RT-PCR at the Central Laboratory in Cairo. Descriptive data analysis was performed for demographic data. Patients’ characteristics were compared by causative agents’ clinical picture and severity using Chi2 with a p < 0.05 significance. Overall, 317 patients were enrolled, 58.3% were ≤ 1 year of age, 61.5% were males. Of 229 (72.7%) of positively tested patients, viruses caused 92.1% including RSV 63.8%, Rhinovirus 10.0%, Influenza 9.2%, Adenovirus 5.2%, and 1.3% co-infected with two viruses. Bacteria caused 3.5% of cases and 4.4% had mixed viral-bacterial infections. Rhinovirus was the most common cause of death among children with SARI, followed by RSV (8.7% and 1.4%), whereas influenza and Adenovirus did not result in any deaths. Patients with viral-bacterial infections are more likely to be admitted to ICU and die at the hospital than bacterial or viral infections (60% and 20% vs. 31.8% and 1.9% vs. 12.5% and 12.5%, p < 0.001). Viruses particularly RSV are the leading cause of SARI causing significant health problem among children < 16 years in Egypt. Bacterial on top of viral infection can worsen disease courses and outcomes. Studies are required to estimate the SARI burden accurately among Egyptian children and a comprehensive approach tailored to Egypt is necessary to reduce its burden. |
| first_indexed | 2024-03-09T01:19:21Z |
| format | Article |
| id | doaj.art-392d61ccf28249c5a31faf43ebcf7c1a |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-09T01:19:21Z |
| publishDate | 2023-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-392d61ccf28249c5a31faf43ebcf7c1a2023-12-10T12:15:24ZengNature PortfolioScientific Reports2045-23222023-12-011311910.1038/s41598-023-48814-xMulticenter study to describe viral etiologies, clinical profiles, and outcomes of hospitalized children with severe acute respiratory infections, Egypt 2022Amr Kandeel0Manal Fahim1Ola Deghedy2Wael H. Roshdy3Mohamed K. Khalifa4Rabeh El Shesheny5Ahmed Kandeil6Saly Wagdy7Amel Naguib8Salma Afifi9Khaled Abdelghaffar10Preventive Sector, Ministry of Health and PopulationPreventive Sector, Ministry of Health and PopulationPreventive Sector, Ministry of Health and PopulationCentral Public Health Laboratories, Ministry of Health and PopulationCentre of Scientific Excellence for Influenza Viruses, National Research CentreCentre of Scientific Excellence for Influenza Viruses, National Research CentreCentre of Scientific Excellence for Influenza Viruses, National Research CentreCentral Public Health Laboratories, Ministry of Health and PopulationCentral Public Health Laboratories, Ministry of Health and PopulationConsultant Ministry of Health and PopulationMinistry of Health and PopulationAbstract In late 2022, severe acute respiratory infections (SARI) surveillance reported an abrupt increase in non-COVID-19 infections among children after three years of drastic reductions. Signals of increased absenteeism due to respiratory symptoms among primary and preparatory school children were detected by Event-Based Surveillance. We conducted a hospital-based survey of children who were admitted with SARI to identify the causative pathogen(s) and estimate the burden of infection. A survey was conducted among children < 16 years in 21 referral hospitals in the three governorates with the highest SARI rates. Patients’ demographics, clinical symptoms, and severity were collected from medical records using a line list. Patients were swabbed and tested for a panel of 33 respiratory pathogens by RT-PCR at the Central Laboratory in Cairo. Descriptive data analysis was performed for demographic data. Patients’ characteristics were compared by causative agents’ clinical picture and severity using Chi2 with a p < 0.05 significance. Overall, 317 patients were enrolled, 58.3% were ≤ 1 year of age, 61.5% were males. Of 229 (72.7%) of positively tested patients, viruses caused 92.1% including RSV 63.8%, Rhinovirus 10.0%, Influenza 9.2%, Adenovirus 5.2%, and 1.3% co-infected with two viruses. Bacteria caused 3.5% of cases and 4.4% had mixed viral-bacterial infections. Rhinovirus was the most common cause of death among children with SARI, followed by RSV (8.7% and 1.4%), whereas influenza and Adenovirus did not result in any deaths. Patients with viral-bacterial infections are more likely to be admitted to ICU and die at the hospital than bacterial or viral infections (60% and 20% vs. 31.8% and 1.9% vs. 12.5% and 12.5%, p < 0.001). Viruses particularly RSV are the leading cause of SARI causing significant health problem among children < 16 years in Egypt. Bacterial on top of viral infection can worsen disease courses and outcomes. Studies are required to estimate the SARI burden accurately among Egyptian children and a comprehensive approach tailored to Egypt is necessary to reduce its burden.https://doi.org/10.1038/s41598-023-48814-x |
| spellingShingle | Amr Kandeel Manal Fahim Ola Deghedy Wael H. Roshdy Mohamed K. Khalifa Rabeh El Shesheny Ahmed Kandeil Saly Wagdy Amel Naguib Salma Afifi Khaled Abdelghaffar Multicenter study to describe viral etiologies, clinical profiles, and outcomes of hospitalized children with severe acute respiratory infections, Egypt 2022 Scientific Reports |
| title | Multicenter study to describe viral etiologies, clinical profiles, and outcomes of hospitalized children with severe acute respiratory infections, Egypt 2022 |
| title_full | Multicenter study to describe viral etiologies, clinical profiles, and outcomes of hospitalized children with severe acute respiratory infections, Egypt 2022 |
| title_fullStr | Multicenter study to describe viral etiologies, clinical profiles, and outcomes of hospitalized children with severe acute respiratory infections, Egypt 2022 |
| title_full_unstemmed | Multicenter study to describe viral etiologies, clinical profiles, and outcomes of hospitalized children with severe acute respiratory infections, Egypt 2022 |
| title_short | Multicenter study to describe viral etiologies, clinical profiles, and outcomes of hospitalized children with severe acute respiratory infections, Egypt 2022 |
| title_sort | multicenter study to describe viral etiologies clinical profiles and outcomes of hospitalized children with severe acute respiratory infections egypt 2022 |
| url | https://doi.org/10.1038/s41598-023-48814-x |
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