Fabrication and Manipulation of Non-Spherical Particles in Microfluidic Channels: A Review
Non-spherical shape is a general appearance feature for bioparticles. Therefore, a mechanical mechanism study of non-spherical particle migration in a microfluidic chip is essential for more precise isolation of target particles. With the manipulation of non-spherical particles, refined disease dete...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-10-01
|
| Series: | Micromachines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-666X/13/10/1659 |
| _version_ | 1797471228240330752 |
|---|---|
| author | Di Jiang Shaowei Liu Wenlai Tang |
| author_facet | Di Jiang Shaowei Liu Wenlai Tang |
| author_sort | Di Jiang |
| collection | DOAJ |
| description | Non-spherical shape is a general appearance feature for bioparticles. Therefore, a mechanical mechanism study of non-spherical particle migration in a microfluidic chip is essential for more precise isolation of target particles. With the manipulation of non-spherical particles, refined disease detection or medical intervention for human beings will be achievable in the future. In this review, fabrication and manipulation of non-spherical particles are discussed. Firstly, various fabrication methods for non-spherical microparticle are introduced. Then, the active and passive manipulation techniques for non-spherical particles are briefly reviewed, including straight inertial microchannels, secondary flow inertial microchannels and deterministic lateral displacement microchannels with extremely high resolution. Finally, applications of viscoelastic flow are presented which obviously increase the precision of non-spherical particle separation. Although various techniques have been employed to improve the performance of non-spherical particle manipulation, the universal mechanism behind this has not been fully discussed. The aim of this review is to provide a reference for non-spherical particle manipulation study researchers in every detail and inspire thoughts for non-spherical particle focused device design. |
| first_indexed | 2024-03-09T19:46:10Z |
| format | Article |
| id | doaj.art-392d62ed7db742bba676aa76fe767c1e |
| institution | Directory Open Access Journal |
| issn | 2072-666X |
| language | English |
| last_indexed | 2024-03-09T19:46:10Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Micromachines |
| spelling | doaj.art-392d62ed7db742bba676aa76fe767c1e2023-11-24T01:22:19ZengMDPI AGMicromachines2072-666X2022-10-011310165910.3390/mi13101659Fabrication and Manipulation of Non-Spherical Particles in Microfluidic Channels: A ReviewDi Jiang0Shaowei Liu1Wenlai Tang2College of Mechanical and Electronic Engineering, Nanjing Forestry University, Nanjing 210037, ChinaCollege of Mechanical and Electronic Engineering, Nanjing Forestry University, Nanjing 210037, ChinaSchool of Electrical and Automation Engineering, Jiangsu Key Laboratory of 3D Printing Equipment and Manufacturing, Nanjing Normal University, Nanjing 210023, ChinaNon-spherical shape is a general appearance feature for bioparticles. Therefore, a mechanical mechanism study of non-spherical particle migration in a microfluidic chip is essential for more precise isolation of target particles. With the manipulation of non-spherical particles, refined disease detection or medical intervention for human beings will be achievable in the future. In this review, fabrication and manipulation of non-spherical particles are discussed. Firstly, various fabrication methods for non-spherical microparticle are introduced. Then, the active and passive manipulation techniques for non-spherical particles are briefly reviewed, including straight inertial microchannels, secondary flow inertial microchannels and deterministic lateral displacement microchannels with extremely high resolution. Finally, applications of viscoelastic flow are presented which obviously increase the precision of non-spherical particle separation. Although various techniques have been employed to improve the performance of non-spherical particle manipulation, the universal mechanism behind this has not been fully discussed. The aim of this review is to provide a reference for non-spherical particle manipulation study researchers in every detail and inspire thoughts for non-spherical particle focused device design.https://www.mdpi.com/2072-666X/13/10/1659microfluidicsnon-spherical particleparticle manipulation |
| spellingShingle | Di Jiang Shaowei Liu Wenlai Tang Fabrication and Manipulation of Non-Spherical Particles in Microfluidic Channels: A Review Micromachines microfluidics non-spherical particle particle manipulation |
| title | Fabrication and Manipulation of Non-Spherical Particles in Microfluidic Channels: A Review |
| title_full | Fabrication and Manipulation of Non-Spherical Particles in Microfluidic Channels: A Review |
| title_fullStr | Fabrication and Manipulation of Non-Spherical Particles in Microfluidic Channels: A Review |
| title_full_unstemmed | Fabrication and Manipulation of Non-Spherical Particles in Microfluidic Channels: A Review |
| title_short | Fabrication and Manipulation of Non-Spherical Particles in Microfluidic Channels: A Review |
| title_sort | fabrication and manipulation of non spherical particles in microfluidic channels a review |
| topic | microfluidics non-spherical particle particle manipulation |
| url | https://www.mdpi.com/2072-666X/13/10/1659 |
| work_keys_str_mv | AT dijiang fabricationandmanipulationofnonsphericalparticlesinmicrofluidicchannelsareview AT shaoweiliu fabricationandmanipulationofnonsphericalparticlesinmicrofluidicchannelsareview AT wenlaitang fabricationandmanipulationofnonsphericalparticlesinmicrofluidicchannelsareview |