Olmesartan medoxomil combined with hydrochlorothiazide for the treatment of hypertension
Mark GreathouseSouth Hills Cardiology Associates of Pittsburgh, Pittsburgh, PA, USAAbstract: In most patients with hypertension, especially Stage 2 hypertension, adequate control of blood pressure (BP) is only achieved with combination drug therapy. When using combination therapy, antihypertensive a...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2006-12-01
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| Series: | Vascular Health and Risk Management |
| Online Access: | https://www.dovepress.com/olmesartan-medoxomil-combined-with-hydrochlorothiazide-for-the-treatme-peer-reviewed-article-VHRM |
| _version_ | 1830474676131856384 |
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| author | Mark Greathouse |
| author_facet | Mark Greathouse |
| author_sort | Mark Greathouse |
| collection | DOAJ |
| description | Mark GreathouseSouth Hills Cardiology Associates of Pittsburgh, Pittsburgh, PA, USAAbstract: In most patients with hypertension, especially Stage 2 hypertension, adequate control of blood pressure (BP) is only achieved with combination drug therapy. When using combination therapy, antihypertensive agents with complementary mechanisms of action are recommended, for example, an angiotensin receptor blocker (ARB) in combination with hydrochlorothiazide (HCTZ), a β-blocker + HCTZ, an ACE inhibitor + HCTZ, or a calcium channel blocker + an ACE inhibitor. One such combination is olmesartan medoxomil + HCTZ, which is available as fixed-dose, single-tablet combinations for once-daily administration. In clinical trials, olmesartan medoxomil/HCTZ reduced systolic BP (SBP) and diastolic BP (DBP) to a greater extent than either component as monotherapy. A clinical study in patients with Stage 1 or 2 hypertension showed that olmesartan medoxomil/HCTZ achieved a similar mean reduction in DBP, but a significantly greater mean reduction in SBP and higher rate of BP control (<140/90 mmHg) than observed with losartan/HCTZ, at US/European-approved starting doses. In a non-inferiority trial, the antihypertensive efficacy of olmesartan medoxomil/HCTZ was comparable to that of atenolol/HCTZ. Furthermore, indirect comparisons have shown that olmesartan medoxomil/HCTZ compares favorably with other antihypertensive combination therapies, including other ARB/HCTZ combinations and amlodipine besylate/benazepril. Olmesartan medoxomil/HCTZ is generally well tolerated. In conclusion, olmesartan medoxomil/HCTZ is an effective and well-tolerated combination antihypertensive therapy that results in significant BP reductions and BP control in many patients. Keywords: olmesartan medoxomil, hydrochlorothiazide, angiotensin II receptor blocker, hypertension |
| first_indexed | 2024-12-21T15:23:56Z |
| format | Article |
| id | doaj.art-392d8bb74207411785c0bd8991c6b9f8 |
| institution | Directory Open Access Journal |
| issn | 1178-2048 |
| language | English |
| last_indexed | 2024-12-21T15:23:56Z |
| publishDate | 2006-12-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Vascular Health and Risk Management |
| spelling | doaj.art-392d8bb74207411785c0bd8991c6b9f82022-12-21T18:58:58ZengDove Medical PressVascular Health and Risk Management1178-20482006-12-01Volume 24014091442Olmesartan medoxomil combined with hydrochlorothiazide for the treatment of hypertensionMark GreathouseMark GreathouseSouth Hills Cardiology Associates of Pittsburgh, Pittsburgh, PA, USAAbstract: In most patients with hypertension, especially Stage 2 hypertension, adequate control of blood pressure (BP) is only achieved with combination drug therapy. When using combination therapy, antihypertensive agents with complementary mechanisms of action are recommended, for example, an angiotensin receptor blocker (ARB) in combination with hydrochlorothiazide (HCTZ), a β-blocker + HCTZ, an ACE inhibitor + HCTZ, or a calcium channel blocker + an ACE inhibitor. One such combination is olmesartan medoxomil + HCTZ, which is available as fixed-dose, single-tablet combinations for once-daily administration. In clinical trials, olmesartan medoxomil/HCTZ reduced systolic BP (SBP) and diastolic BP (DBP) to a greater extent than either component as monotherapy. A clinical study in patients with Stage 1 or 2 hypertension showed that olmesartan medoxomil/HCTZ achieved a similar mean reduction in DBP, but a significantly greater mean reduction in SBP and higher rate of BP control (<140/90 mmHg) than observed with losartan/HCTZ, at US/European-approved starting doses. In a non-inferiority trial, the antihypertensive efficacy of olmesartan medoxomil/HCTZ was comparable to that of atenolol/HCTZ. Furthermore, indirect comparisons have shown that olmesartan medoxomil/HCTZ compares favorably with other antihypertensive combination therapies, including other ARB/HCTZ combinations and amlodipine besylate/benazepril. Olmesartan medoxomil/HCTZ is generally well tolerated. In conclusion, olmesartan medoxomil/HCTZ is an effective and well-tolerated combination antihypertensive therapy that results in significant BP reductions and BP control in many patients. Keywords: olmesartan medoxomil, hydrochlorothiazide, angiotensin II receptor blocker, hypertensionhttps://www.dovepress.com/olmesartan-medoxomil-combined-with-hydrochlorothiazide-for-the-treatme-peer-reviewed-article-VHRM |
| spellingShingle | Mark Greathouse Olmesartan medoxomil combined with hydrochlorothiazide for the treatment of hypertension Vascular Health and Risk Management |
| title | Olmesartan medoxomil combined with hydrochlorothiazide for the treatment of hypertension |
| title_full | Olmesartan medoxomil combined with hydrochlorothiazide for the treatment of hypertension |
| title_fullStr | Olmesartan medoxomil combined with hydrochlorothiazide for the treatment of hypertension |
| title_full_unstemmed | Olmesartan medoxomil combined with hydrochlorothiazide for the treatment of hypertension |
| title_short | Olmesartan medoxomil combined with hydrochlorothiazide for the treatment of hypertension |
| title_sort | olmesartan medoxomil combined with hydrochlorothiazide for the treatment of hypertension |
| url | https://www.dovepress.com/olmesartan-medoxomil-combined-with-hydrochlorothiazide-for-the-treatme-peer-reviewed-article-VHRM |
| work_keys_str_mv | AT markgreathouse olmesartanmedoxomilcombinedwithhydrochlorothiazideforthetreatmentofhypertension |