Assessment of Naturally Sourced Mineral Clays for the 3D Printing of Biopolymer-Based Nanocomposite Inks
The present study investigated the possibility of obtaining 3D printed composite constructs using biomaterial-based nanocomposite inks. The biopolymeric matrix consisted of methacrylated gelatin (GelMA). Several types of nanoclay were added as the inorganic component. Our aim was to investigate the...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-03-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/11/3/703 |
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| author | Rebeca Leu Alexa Horia Iovu Bogdan Trica Catalin Zaharia Andrada Serafim Elvira Alexandrescu Ionut-Cristian Radu George Vlasceanu Silviu Preda Claudia Mihaela Ninciuleanu Raluca Ianchis |
| author_facet | Rebeca Leu Alexa Horia Iovu Bogdan Trica Catalin Zaharia Andrada Serafim Elvira Alexandrescu Ionut-Cristian Radu George Vlasceanu Silviu Preda Claudia Mihaela Ninciuleanu Raluca Ianchis |
| author_sort | Rebeca Leu Alexa |
| collection | DOAJ |
| description | The present study investigated the possibility of obtaining 3D printed composite constructs using biomaterial-based nanocomposite inks. The biopolymeric matrix consisted of methacrylated gelatin (GelMA). Several types of nanoclay were added as the inorganic component. Our aim was to investigate the influence of clay type on the rheological behavior of ink formulations and to determine the morphological and structural properties of the resulting crosslinked hydrogel-based nanomaterials. Moreover, through the inclusion of nanoclays, our goal was to improve the printability and shape fidelity of nanocomposite scaffolds. The viscosity of all ink formulations was greater in the presence of inorganic nanoparticles as shear thinning occurred with increased shear rate. Hydrogel nanocomposites presented predominantly elastic rather than viscous behavior as the materials were crosslinked which led to improved mechanical properties. The inclusion of nanoclays in the biopolymeric matrix limited hydrogel swelling due the physical barrier effect but also because of the supplementary crosslinks induced by the clay layers. The distribution of inorganic filler within the GelMA-based hydrogels led to higher porosities as a consequence of their interaction with the biopolymeric ink. The present study could be useful for the development of soft nanomaterials foreseen for the additive manufacturing of customized implants for tissue engineering. |
| first_indexed | 2024-03-10T13:21:06Z |
| format | Article |
| id | doaj.art-392dd4658261455cadcdb86776caea9a |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-03-10T13:21:06Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-392dd4658261455cadcdb86776caea9a2023-11-21T10:02:10ZengMDPI AGNanomaterials2079-49912021-03-0111370310.3390/nano11030703Assessment of Naturally Sourced Mineral Clays for the 3D Printing of Biopolymer-Based Nanocomposite InksRebeca Leu Alexa0Horia Iovu1Bogdan Trica2Catalin Zaharia3Andrada Serafim4Elvira Alexandrescu5Ionut-Cristian Radu6George Vlasceanu7Silviu Preda8Claudia Mihaela Ninciuleanu9Raluca Ianchis10Advanced Polymer Materials Group, Department of Bioresources and Polymer Science, Politehnica University of Bucharest, 011061 Bucharest, RomaniaAdvanced Polymer Materials Group, Department of Bioresources and Polymer Science, Politehnica University of Bucharest, 011061 Bucharest, RomaniaNational R-D Institute for Chemistry and Petrochemistry ICECHIM—Bucharest, Splaiul Independentei 202, 6th District, P.O. Box 35/174, 060021 Bucharest, RomaniaAdvanced Polymer Materials Group, Department of Bioresources and Polymer Science, Politehnica University of Bucharest, 011061 Bucharest, RomaniaAdvanced Polymer Materials Group, Department of Bioresources and Polymer Science, Politehnica University of Bucharest, 011061 Bucharest, RomaniaNational R-D Institute for Chemistry and Petrochemistry ICECHIM—Bucharest, Splaiul Independentei 202, 6th District, P.O. Box 35/174, 060021 Bucharest, RomaniaAdvanced Polymer Materials Group, Department of Bioresources and Polymer Science, Politehnica University of Bucharest, 011061 Bucharest, RomaniaFaculty of Medical Engineering, University Politehnica of Bucharest, Gheorghe Polizu 1-7, 011061 Bucharest, RomaniaInstitute of Physical Chemistry “Ilie Murgulescu”, Romanian Academy, Splaiul Independentei 202, 6th District, 060021 Bucharest, RomaniaNational R-D Institute for Chemistry and Petrochemistry ICECHIM—Bucharest, Splaiul Independentei 202, 6th District, P.O. Box 35/174, 060021 Bucharest, RomaniaNational R-D Institute for Chemistry and Petrochemistry ICECHIM—Bucharest, Splaiul Independentei 202, 6th District, P.O. Box 35/174, 060021 Bucharest, RomaniaThe present study investigated the possibility of obtaining 3D printed composite constructs using biomaterial-based nanocomposite inks. The biopolymeric matrix consisted of methacrylated gelatin (GelMA). Several types of nanoclay were added as the inorganic component. Our aim was to investigate the influence of clay type on the rheological behavior of ink formulations and to determine the morphological and structural properties of the resulting crosslinked hydrogel-based nanomaterials. Moreover, through the inclusion of nanoclays, our goal was to improve the printability and shape fidelity of nanocomposite scaffolds. The viscosity of all ink formulations was greater in the presence of inorganic nanoparticles as shear thinning occurred with increased shear rate. Hydrogel nanocomposites presented predominantly elastic rather than viscous behavior as the materials were crosslinked which led to improved mechanical properties. The inclusion of nanoclays in the biopolymeric matrix limited hydrogel swelling due the physical barrier effect but also because of the supplementary crosslinks induced by the clay layers. The distribution of inorganic filler within the GelMA-based hydrogels led to higher porosities as a consequence of their interaction with the biopolymeric ink. The present study could be useful for the development of soft nanomaterials foreseen for the additive manufacturing of customized implants for tissue engineering.https://www.mdpi.com/2079-4991/11/3/703nanocompositesnanoclaybiopolymerhydrogelinks3D printing |
| spellingShingle | Rebeca Leu Alexa Horia Iovu Bogdan Trica Catalin Zaharia Andrada Serafim Elvira Alexandrescu Ionut-Cristian Radu George Vlasceanu Silviu Preda Claudia Mihaela Ninciuleanu Raluca Ianchis Assessment of Naturally Sourced Mineral Clays for the 3D Printing of Biopolymer-Based Nanocomposite Inks Nanomaterials nanocomposites nanoclay biopolymer hydrogel inks 3D printing |
| title | Assessment of Naturally Sourced Mineral Clays for the 3D Printing of Biopolymer-Based Nanocomposite Inks |
| title_full | Assessment of Naturally Sourced Mineral Clays for the 3D Printing of Biopolymer-Based Nanocomposite Inks |
| title_fullStr | Assessment of Naturally Sourced Mineral Clays for the 3D Printing of Biopolymer-Based Nanocomposite Inks |
| title_full_unstemmed | Assessment of Naturally Sourced Mineral Clays for the 3D Printing of Biopolymer-Based Nanocomposite Inks |
| title_short | Assessment of Naturally Sourced Mineral Clays for the 3D Printing of Biopolymer-Based Nanocomposite Inks |
| title_sort | assessment of naturally sourced mineral clays for the 3d printing of biopolymer based nanocomposite inks |
| topic | nanocomposites nanoclay biopolymer hydrogel inks 3D printing |
| url | https://www.mdpi.com/2079-4991/11/3/703 |
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