A study to evaluate the role of intradermal and intralesional measles, mumps, rubella (MMR) vaccine in treatment of common warts
Background: Warts are common cutaneous viral infection with a wide range of therapeutic modalities. Various agents have been tried for immunotherapy in warts. Objectives: Determine the role of intralesional and intradermal measles, mumps, rubella (MMR) vaccine in the treatment of common warts; to co...
| المؤلفون الرئيسيون: | , , , , , |
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| التنسيق: | مقال |
| اللغة: | English |
| منشور في: |
Wolters Kluwer Medknow Publications
2020-01-01
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| سلاسل: | Indian Dermatology Online Journal |
| الموضوعات: | |
| الوصول للمادة أونلاين: | http://www.idoj.in/article.asp?issn=2229-5178;year=2020;volume=11;issue=4;spage=559;epage=565;aulast=Gupta |
| _version_ | 1828379954595758080 |
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| author | Pragya Gupta Geeta Ram Tegta G K Verma Abhishek Gupta Mudita Gupta Shikha Sharma |
| author_facet | Pragya Gupta Geeta Ram Tegta G K Verma Abhishek Gupta Mudita Gupta Shikha Sharma |
| author_sort | Pragya Gupta |
| collection | DOAJ |
| description | Background: Warts are common cutaneous viral infection with a wide range of therapeutic modalities. Various agents have been tried for immunotherapy in warts. Objectives: Determine the role of intralesional and intradermal measles, mumps, rubella (MMR) vaccine in the treatment of common warts; to compare the efficacy of intralesional versus intradermal MMR vaccine. Methods and Materials: Patients diagnosed with verruca vulgaris were divided into two groups. In study group A, the individuals were injected with an intralesional MMR vaccine of 0.3 mL in the representative wart (largest) once in 3 weeks till there is complete clearance or maximum of four injections whichever is earlier, while in study group B, the individuals were injected with an intradermal MMR vaccine of 0.3 mL over the unilateral deltoid muscle area at similar intervals. Results: There were 33 patients in each group. In group A, 10 (30.3%) patients showed complete, 9 (27.3%) marked, 6 (18.2%) moderate, 3 (9.1%) mild, and 5 (15.2%) no response. In group B, seven (21.2%) patients showed complete, one (3.0%) marked, one (3.0%) moderate, four (12.1%) mild, and 20 (60.6%) no response. There were minimal side effects in the form of pain, erythema, itching at the injection site in a few patients, only one patient had syncope. Conclusion: We conclude that the MMR vaccine is an effective and safe modality of treatment for verruca vulgaris without any serious adverse effects. Also, the intralesional route showed better results in comparison to the intradermal route when we consider the treatment of a representative wart. |
| first_indexed | 2024-12-10T03:50:00Z |
| format | Article |
| id | doaj.art-392e34d6fc8f42cfb83b4f7ba9a0c6c0 |
| institution | Directory Open Access Journal |
| issn | 2229-5178 |
| language | English |
| last_indexed | 2024-12-10T03:50:00Z |
| publishDate | 2020-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Dermatology Online Journal |
| spelling | doaj.art-392e34d6fc8f42cfb83b4f7ba9a0c6c02022-12-22T02:03:18ZengWolters Kluwer Medknow PublicationsIndian Dermatology Online Journal2229-51782020-01-0111455956510.4103/idoj.IDOJ_144_19A study to evaluate the role of intradermal and intralesional measles, mumps, rubella (MMR) vaccine in treatment of common wartsPragya GuptaGeeta Ram TegtaG K VermaAbhishek GuptaMudita GuptaShikha SharmaBackground: Warts are common cutaneous viral infection with a wide range of therapeutic modalities. Various agents have been tried for immunotherapy in warts. Objectives: Determine the role of intralesional and intradermal measles, mumps, rubella (MMR) vaccine in the treatment of common warts; to compare the efficacy of intralesional versus intradermal MMR vaccine. Methods and Materials: Patients diagnosed with verruca vulgaris were divided into two groups. In study group A, the individuals were injected with an intralesional MMR vaccine of 0.3 mL in the representative wart (largest) once in 3 weeks till there is complete clearance or maximum of four injections whichever is earlier, while in study group B, the individuals were injected with an intradermal MMR vaccine of 0.3 mL over the unilateral deltoid muscle area at similar intervals. Results: There were 33 patients in each group. In group A, 10 (30.3%) patients showed complete, 9 (27.3%) marked, 6 (18.2%) moderate, 3 (9.1%) mild, and 5 (15.2%) no response. In group B, seven (21.2%) patients showed complete, one (3.0%) marked, one (3.0%) moderate, four (12.1%) mild, and 20 (60.6%) no response. There were minimal side effects in the form of pain, erythema, itching at the injection site in a few patients, only one patient had syncope. Conclusion: We conclude that the MMR vaccine is an effective and safe modality of treatment for verruca vulgaris without any serious adverse effects. Also, the intralesional route showed better results in comparison to the intradermal route when we consider the treatment of a representative wart.http://www.idoj.in/article.asp?issn=2229-5178;year=2020;volume=11;issue=4;spage=559;epage=565;aulast=Guptaimmunotherapyintradermalintralesionalmmr vaccinewart |
| spellingShingle | Pragya Gupta Geeta Ram Tegta G K Verma Abhishek Gupta Mudita Gupta Shikha Sharma A study to evaluate the role of intradermal and intralesional measles, mumps, rubella (MMR) vaccine in treatment of common warts Indian Dermatology Online Journal immunotherapy intradermal intralesional mmr vaccine wart |
| title | A study to evaluate the role of intradermal and intralesional measles, mumps, rubella (MMR) vaccine in treatment of common warts |
| title_full | A study to evaluate the role of intradermal and intralesional measles, mumps, rubella (MMR) vaccine in treatment of common warts |
| title_fullStr | A study to evaluate the role of intradermal and intralesional measles, mumps, rubella (MMR) vaccine in treatment of common warts |
| title_full_unstemmed | A study to evaluate the role of intradermal and intralesional measles, mumps, rubella (MMR) vaccine in treatment of common warts |
| title_short | A study to evaluate the role of intradermal and intralesional measles, mumps, rubella (MMR) vaccine in treatment of common warts |
| title_sort | study to evaluate the role of intradermal and intralesional measles mumps rubella mmr vaccine in treatment of common warts |
| topic | immunotherapy intradermal intralesional mmr vaccine wart |
| url | http://www.idoj.in/article.asp?issn=2229-5178;year=2020;volume=11;issue=4;spage=559;epage=565;aulast=Gupta |
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