Functional dissociation of hippocampal subregions corresponding to memory types and stages
Abstract Background The hippocampus reportedly plays a crucial role in memory. However, examining individual human hippocampal-subfield function remains challenging because of their small sizes and convoluted structures. Here, we identified hippocampal subregions involved in memory types (implicit a...
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| Format: | Article |
| Language: | English |
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BMC
2020-07-01
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| Series: | Journal of Physiological Anthropology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s40101-020-00225-x |
| _version_ | 1819227611330510848 |
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| author | Ji-Woo Seok Chaejoon Cheong |
| author_facet | Ji-Woo Seok Chaejoon Cheong |
| author_sort | Ji-Woo Seok |
| collection | DOAJ |
| description | Abstract Background The hippocampus reportedly plays a crucial role in memory. However, examining individual human hippocampal-subfield function remains challenging because of their small sizes and convoluted structures. Here, we identified hippocampal subregions involved in memory types (implicit and explicit memory) and stages (encoding and retrieval). Methods We modified the serial reaction time task to examine four memory types, i.e. implicit encoding, explicit encoding, implicit retrieval, and explicit retrieval. During this task, 7-T functional magnetic resonance imaging was used to compare brain activity evoked by these memory types. Results We found hippocampal activation according to all memory types and stages and identified that the hippocampus subserves both implicit and explicit memory processing. Moreover, we confirmed that cornu ammonis (CA) regions 1–3 were implicated in both memory encoding and retrieval, whereas the subiculum was implicated only in memory retrieval. We also found that CA 1–3 was activated more for explicit than implicit memory. Conclusions These results elucidate human hippocampal-subfield functioning underlying memory and may support future investigations into hippocampal-subfield functioning in health and neurodegenerative disease. |
| first_indexed | 2024-12-23T10:44:08Z |
| format | Article |
| id | doaj.art-392efa2d06d64397b1c5f7469602a603 |
| institution | Directory Open Access Journal |
| issn | 1880-6805 |
| language | English |
| last_indexed | 2024-12-23T10:44:08Z |
| publishDate | 2020-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Physiological Anthropology |
| spelling | doaj.art-392efa2d06d64397b1c5f7469602a6032022-12-21T17:50:05ZengBMCJournal of Physiological Anthropology1880-68052020-07-0139111110.1186/s40101-020-00225-xFunctional dissociation of hippocampal subregions corresponding to memory types and stagesJi-Woo Seok0Chaejoon Cheong1Department of Psychiatry, University of Nebraska Medical CenterCenter for Research Equipment, Korea Basic Science InstituteAbstract Background The hippocampus reportedly plays a crucial role in memory. However, examining individual human hippocampal-subfield function remains challenging because of their small sizes and convoluted structures. Here, we identified hippocampal subregions involved in memory types (implicit and explicit memory) and stages (encoding and retrieval). Methods We modified the serial reaction time task to examine four memory types, i.e. implicit encoding, explicit encoding, implicit retrieval, and explicit retrieval. During this task, 7-T functional magnetic resonance imaging was used to compare brain activity evoked by these memory types. Results We found hippocampal activation according to all memory types and stages and identified that the hippocampus subserves both implicit and explicit memory processing. Moreover, we confirmed that cornu ammonis (CA) regions 1–3 were implicated in both memory encoding and retrieval, whereas the subiculum was implicated only in memory retrieval. We also found that CA 1–3 was activated more for explicit than implicit memory. Conclusions These results elucidate human hippocampal-subfield functioning underlying memory and may support future investigations into hippocampal-subfield functioning in health and neurodegenerative disease.http://link.springer.com/article/10.1186/s40101-020-00225-xHippocampusUltra-high field fMRICA 1–3SubiculumImplicit memoryExplicit memory |
| spellingShingle | Ji-Woo Seok Chaejoon Cheong Functional dissociation of hippocampal subregions corresponding to memory types and stages Journal of Physiological Anthropology Hippocampus Ultra-high field fMRI CA 1–3 Subiculum Implicit memory Explicit memory |
| title | Functional dissociation of hippocampal subregions corresponding to memory types and stages |
| title_full | Functional dissociation of hippocampal subregions corresponding to memory types and stages |
| title_fullStr | Functional dissociation of hippocampal subregions corresponding to memory types and stages |
| title_full_unstemmed | Functional dissociation of hippocampal subregions corresponding to memory types and stages |
| title_short | Functional dissociation of hippocampal subregions corresponding to memory types and stages |
| title_sort | functional dissociation of hippocampal subregions corresponding to memory types and stages |
| topic | Hippocampus Ultra-high field fMRI CA 1–3 Subiculum Implicit memory Explicit memory |
| url | http://link.springer.com/article/10.1186/s40101-020-00225-x |
| work_keys_str_mv | AT jiwooseok functionaldissociationofhippocampalsubregionscorrespondingtomemorytypesandstages AT chaejooncheong functionaldissociationofhippocampalsubregionscorrespondingtomemorytypesandstages |