Soybean oil increases SERCA2a expression and left ventricular contractility in rats without change in arterial blood pressure
<p>Abstract</p> <p>Background</p> <p>Our aim was to evaluate the effects of soybean oil treatment for 15 days on arterial and ventricular pressure, myocardial mechanics and proteins involved in calcium handling.</p> <p>Methods</p> <p>Wistar rats...
Main Authors: | , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2010-05-01
|
Series: | Lipids in Health and Disease |
Online Access: | http://www.lipidworld.com/content/9/1/53 |
_version_ | 1811287044980211712 |
---|---|
author | Vassallo Dalton Magalhães Siman Fabiana Batista Priscila Meira Eduardo Fernandes Aurélia Ribeiro Rogério Padilha Alessandra Stefanon Ivanita |
author_facet | Vassallo Dalton Magalhães Siman Fabiana Batista Priscila Meira Eduardo Fernandes Aurélia Ribeiro Rogério Padilha Alessandra Stefanon Ivanita |
author_sort | Vassallo Dalton |
collection | DOAJ |
description | <p>Abstract</p> <p>Background</p> <p>Our aim was to evaluate the effects of soybean oil treatment for 15 days on arterial and ventricular pressure, myocardial mechanics and proteins involved in calcium handling.</p> <p>Methods</p> <p>Wistar rats were divided in two groups receiving 100 μL of soybean oil (SB) or saline (CT) i.m. for 15 days. Ventricular performance was analyzed in male 12-weeks old Wistar rats by measuring left ventricle diastolic and systolic pressure in isolated perfused hearts according to the Langendorff technique. Protein expression was measured by Western blot analysis.</p> <p>Results</p> <p>Systolic and diastolic arterial pressures did not differ between CT and SB rats. However, heart rate was reduced in the SB group. In the perfused hearts, left ventricular isovolumetric systolic pressure was higher in the SB hearts. The inotropic response to extracellular Ca<sup>2+ </sup>and isoproterenol was higher in the soybean-treated animals than in the control group. Myosin ATPase and Na<sup>+</sup>-K<sup>+</sup>ATPase activities, the expression of sarcoplasmic reticulum calcium pump (SERCA2a) and sodium calcium exchanger (NCX) were increased in the SB group. Although the phosfolamban (PLB) expression did not change, its phosphorylation at Ser<sup>16 </sup>was reduced while the SERCA2a/PLB ratio was increased.</p> <p>Conclusions</p> <p>In summary, soybean treatment for 15 days in rats increases the left ventricular performance without affecting arterial blood pressure. These changes might be associated with an increase in the myosin ATPase activity and SERCA2a expression.</p> |
first_indexed | 2024-04-13T03:11:48Z |
format | Article |
id | doaj.art-3930899bfa9d40f19f136e9cbb05080e |
institution | Directory Open Access Journal |
issn | 1476-511X |
language | English |
last_indexed | 2024-04-13T03:11:48Z |
publishDate | 2010-05-01 |
publisher | BMC |
record_format | Article |
series | Lipids in Health and Disease |
spelling | doaj.art-3930899bfa9d40f19f136e9cbb05080e2022-12-22T03:05:01ZengBMCLipids in Health and Disease1476-511X2010-05-01915310.1186/1476-511X-9-53Soybean oil increases SERCA2a expression and left ventricular contractility in rats without change in arterial blood pressureVassallo DaltonMagalhães Siman FabianaBatista PriscilaMeira EduardoFernandes AuréliaRibeiro RogérioPadilha AlessandraStefanon Ivanita<p>Abstract</p> <p>Background</p> <p>Our aim was to evaluate the effects of soybean oil treatment for 15 days on arterial and ventricular pressure, myocardial mechanics and proteins involved in calcium handling.</p> <p>Methods</p> <p>Wistar rats were divided in two groups receiving 100 μL of soybean oil (SB) or saline (CT) i.m. for 15 days. Ventricular performance was analyzed in male 12-weeks old Wistar rats by measuring left ventricle diastolic and systolic pressure in isolated perfused hearts according to the Langendorff technique. Protein expression was measured by Western blot analysis.</p> <p>Results</p> <p>Systolic and diastolic arterial pressures did not differ between CT and SB rats. However, heart rate was reduced in the SB group. In the perfused hearts, left ventricular isovolumetric systolic pressure was higher in the SB hearts. The inotropic response to extracellular Ca<sup>2+ </sup>and isoproterenol was higher in the soybean-treated animals than in the control group. Myosin ATPase and Na<sup>+</sup>-K<sup>+</sup>ATPase activities, the expression of sarcoplasmic reticulum calcium pump (SERCA2a) and sodium calcium exchanger (NCX) were increased in the SB group. Although the phosfolamban (PLB) expression did not change, its phosphorylation at Ser<sup>16 </sup>was reduced while the SERCA2a/PLB ratio was increased.</p> <p>Conclusions</p> <p>In summary, soybean treatment for 15 days in rats increases the left ventricular performance without affecting arterial blood pressure. These changes might be associated with an increase in the myosin ATPase activity and SERCA2a expression.</p>http://www.lipidworld.com/content/9/1/53 |
spellingShingle | Vassallo Dalton Magalhães Siman Fabiana Batista Priscila Meira Eduardo Fernandes Aurélia Ribeiro Rogério Padilha Alessandra Stefanon Ivanita Soybean oil increases SERCA2a expression and left ventricular contractility in rats without change in arterial blood pressure Lipids in Health and Disease |
title | Soybean oil increases SERCA2a expression and left ventricular contractility in rats without change in arterial blood pressure |
title_full | Soybean oil increases SERCA2a expression and left ventricular contractility in rats without change in arterial blood pressure |
title_fullStr | Soybean oil increases SERCA2a expression and left ventricular contractility in rats without change in arterial blood pressure |
title_full_unstemmed | Soybean oil increases SERCA2a expression and left ventricular contractility in rats without change in arterial blood pressure |
title_short | Soybean oil increases SERCA2a expression and left ventricular contractility in rats without change in arterial blood pressure |
title_sort | soybean oil increases serca2a expression and left ventricular contractility in rats without change in arterial blood pressure |
url | http://www.lipidworld.com/content/9/1/53 |
work_keys_str_mv | AT vassallodalton soybeanoilincreasesserca2aexpressionandleftventricularcontractilityinratswithoutchangeinarterialbloodpressure AT magalhaessimanfabiana soybeanoilincreasesserca2aexpressionandleftventricularcontractilityinratswithoutchangeinarterialbloodpressure AT batistapriscila soybeanoilincreasesserca2aexpressionandleftventricularcontractilityinratswithoutchangeinarterialbloodpressure AT meiraeduardo soybeanoilincreasesserca2aexpressionandleftventricularcontractilityinratswithoutchangeinarterialbloodpressure AT fernandesaurelia soybeanoilincreasesserca2aexpressionandleftventricularcontractilityinratswithoutchangeinarterialbloodpressure AT ribeirorogerio soybeanoilincreasesserca2aexpressionandleftventricularcontractilityinratswithoutchangeinarterialbloodpressure AT padilhaalessandra soybeanoilincreasesserca2aexpressionandleftventricularcontractilityinratswithoutchangeinarterialbloodpressure AT stefanonivanita soybeanoilincreasesserca2aexpressionandleftventricularcontractilityinratswithoutchangeinarterialbloodpressure |