Triple-negative breast cancer arising in a fibroadenoma in BRCA 1 mutated patient
We describe the case of a 35-year-old woman who comes to our institute with a palpable lump on her left breast. Clinically the mass was mobile, nontender and with no nipple discharge. Sonography revealed a circumscribed, oval-shaped, and hypoechoic mass, suggestive of a benign lesion. We performed a...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Journal of Medical Ultrasound |
| Subjects: | |
| Online Access: | http://www.jmuonline.org/article.asp?issn=0929-6441;year=2023;volume=31;issue=1;spage=63;epage=65;aulast=Brunetti |
| _version_ | 1797775476043808768 |
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| author | Nicole Brunetti Irene Valente Francesca Pitto Massimo Calabrese |
| author_facet | Nicole Brunetti Irene Valente Francesca Pitto Massimo Calabrese |
| author_sort | Nicole Brunetti |
| collection | DOAJ |
| description | We describe the case of a 35-year-old woman who comes to our institute with a palpable lump on her left breast. Clinically the mass was mobile, nontender and with no nipple discharge. Sonography revealed a circumscribed, oval-shaped, and hypoechoic mass, suggestive of a benign lesion. We performed an ultrasound-guided core needle biopsy that demonstrated multiple foci of high-grade (G3) ductal carcinoma in situ arising on fibroadenoma (FA). Subsequently, the patient had surgical excision of the mass with a final diagnosis of triple-negative breast cancer arising on FA. After diagnosis, the patient performs a genetic test that detects the BRCA 1 gene mutation. A review of the literature demonstrated only two cases of triple-negative breast cancer on FA. In this report, we describe another such case. |
| first_indexed | 2024-03-12T22:36:17Z |
| format | Article |
| id | doaj.art-3932c4bf60544a7fb1b10a7ce990dc4d |
| institution | Directory Open Access Journal |
| issn | 0929-6441 2212-1552 |
| language | English |
| last_indexed | 2024-03-12T22:36:17Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Medical Ultrasound |
| spelling | doaj.art-3932c4bf60544a7fb1b10a7ce990dc4d2023-07-21T11:55:19ZengWolters Kluwer Medknow PublicationsJournal of Medical Ultrasound0929-64412212-15522023-01-01311636510.4103/jmu.jmu_83_21Triple-negative breast cancer arising in a fibroadenoma in BRCA 1 mutated patientNicole BrunettiIrene ValenteFrancesca PittoMassimo CalabreseWe describe the case of a 35-year-old woman who comes to our institute with a palpable lump on her left breast. Clinically the mass was mobile, nontender and with no nipple discharge. Sonography revealed a circumscribed, oval-shaped, and hypoechoic mass, suggestive of a benign lesion. We performed an ultrasound-guided core needle biopsy that demonstrated multiple foci of high-grade (G3) ductal carcinoma in situ arising on fibroadenoma (FA). Subsequently, the patient had surgical excision of the mass with a final diagnosis of triple-negative breast cancer arising on FA. After diagnosis, the patient performs a genetic test that detects the BRCA 1 gene mutation. A review of the literature demonstrated only two cases of triple-negative breast cancer on FA. In this report, we describe another such case.http://www.jmuonline.org/article.asp?issn=0929-6441;year=2023;volume=31;issue=1;spage=63;epage=65;aulast=Brunettibrcabreast cancer on fibroadenomatriple-negative breast cancer |
| spellingShingle | Nicole Brunetti Irene Valente Francesca Pitto Massimo Calabrese Triple-negative breast cancer arising in a fibroadenoma in BRCA 1 mutated patient Journal of Medical Ultrasound brca breast cancer on fibroadenoma triple-negative breast cancer |
| title | Triple-negative breast cancer arising in a fibroadenoma in BRCA 1 mutated patient |
| title_full | Triple-negative breast cancer arising in a fibroadenoma in BRCA 1 mutated patient |
| title_fullStr | Triple-negative breast cancer arising in a fibroadenoma in BRCA 1 mutated patient |
| title_full_unstemmed | Triple-negative breast cancer arising in a fibroadenoma in BRCA 1 mutated patient |
| title_short | Triple-negative breast cancer arising in a fibroadenoma in BRCA 1 mutated patient |
| title_sort | triple negative breast cancer arising in a fibroadenoma in brca 1 mutated patient |
| topic | brca breast cancer on fibroadenoma triple-negative breast cancer |
| url | http://www.jmuonline.org/article.asp?issn=0929-6441;year=2023;volume=31;issue=1;spage=63;epage=65;aulast=Brunetti |
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