An Update on Graphene-Based Nanomaterials for Neural Growth and Central Nervous System Regeneration
Thanks to their reduced size, great surface area, and capacity to interact with cells and tissues, nanomaterials present some attractive biological and chemical characteristics with potential uses in the field of biomedical applications. In this context, graphene and its chemical derivatives have be...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/23/13047 |
| _version_ | 1797507695668887552 |
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| author | Maria Grazia Tupone Gloria Panella Michele d’Angelo Vanessa Castelli Giulia Caioni Mariano Catanesi Elisabetta Benedetti Annamaria Cimini |
| author_facet | Maria Grazia Tupone Gloria Panella Michele d’Angelo Vanessa Castelli Giulia Caioni Mariano Catanesi Elisabetta Benedetti Annamaria Cimini |
| author_sort | Maria Grazia Tupone |
| collection | DOAJ |
| description | Thanks to their reduced size, great surface area, and capacity to interact with cells and tissues, nanomaterials present some attractive biological and chemical characteristics with potential uses in the field of biomedical applications. In this context, graphene and its chemical derivatives have been extensively used in many biomedical research areas from drug delivery to bioelectronics and tissue engineering. Graphene-based nanomaterials show excellent optical, mechanical, and biological properties. They can be used as a substrate in the field of tissue engineering due to their conductivity, allowing to study, and educate neural connections, and guide neural growth and differentiation; thus, graphene-based nanomaterials represent an emerging aspect in regenerative medicine. Moreover, there is now an urgent need to develop multifunctional and functionalized nanomaterials able to arrive at neuronal cells through the blood-brain barrier, to manage a specific drug delivery system. In this review, we will focus on the recent applications of graphene-based nanomaterials in vitro and in vivo, also combining graphene with other smart materials to achieve the best benefits in the fields of nervous tissue engineering and neural regenerative medicine. We will then highlight the potential use of these graphene-based materials to construct graphene 3D scaffolds able to stimulate neural growth and regeneration in vivo for clinical applications. |
| first_indexed | 2024-03-10T04:52:06Z |
| format | Article |
| id | doaj.art-3933246ad9054591b4b17e7e710c0c77 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T04:52:06Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-3933246ad9054591b4b17e7e710c0c772023-11-23T02:32:19ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-12-0122231304710.3390/ijms222313047An Update on Graphene-Based Nanomaterials for Neural Growth and Central Nervous System RegenerationMaria Grazia Tupone0Gloria Panella1Michele d’Angelo2Vanessa Castelli3Giulia Caioni4Mariano Catanesi5Elisabetta Benedetti6Annamaria Cimini7Department of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, ItalyDepartment of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, ItalyDepartment of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, ItalyDepartment of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, ItalyDepartment of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, ItalyDepartment of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, ItalyDepartment of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, ItalyDepartment of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, ItalyThanks to their reduced size, great surface area, and capacity to interact with cells and tissues, nanomaterials present some attractive biological and chemical characteristics with potential uses in the field of biomedical applications. In this context, graphene and its chemical derivatives have been extensively used in many biomedical research areas from drug delivery to bioelectronics and tissue engineering. Graphene-based nanomaterials show excellent optical, mechanical, and biological properties. They can be used as a substrate in the field of tissue engineering due to their conductivity, allowing to study, and educate neural connections, and guide neural growth and differentiation; thus, graphene-based nanomaterials represent an emerging aspect in regenerative medicine. Moreover, there is now an urgent need to develop multifunctional and functionalized nanomaterials able to arrive at neuronal cells through the blood-brain barrier, to manage a specific drug delivery system. In this review, we will focus on the recent applications of graphene-based nanomaterials in vitro and in vivo, also combining graphene with other smart materials to achieve the best benefits in the fields of nervous tissue engineering and neural regenerative medicine. We will then highlight the potential use of these graphene-based materials to construct graphene 3D scaffolds able to stimulate neural growth and regeneration in vivo for clinical applications.https://www.mdpi.com/1422-0067/22/23/13047nanomaterialsgraphenegraphene-oxidetissue engineeringregenerative medicine |
| spellingShingle | Maria Grazia Tupone Gloria Panella Michele d’Angelo Vanessa Castelli Giulia Caioni Mariano Catanesi Elisabetta Benedetti Annamaria Cimini An Update on Graphene-Based Nanomaterials for Neural Growth and Central Nervous System Regeneration International Journal of Molecular Sciences nanomaterials graphene graphene-oxide tissue engineering regenerative medicine |
| title | An Update on Graphene-Based Nanomaterials for Neural Growth and Central Nervous System Regeneration |
| title_full | An Update on Graphene-Based Nanomaterials for Neural Growth and Central Nervous System Regeneration |
| title_fullStr | An Update on Graphene-Based Nanomaterials for Neural Growth and Central Nervous System Regeneration |
| title_full_unstemmed | An Update on Graphene-Based Nanomaterials for Neural Growth and Central Nervous System Regeneration |
| title_short | An Update on Graphene-Based Nanomaterials for Neural Growth and Central Nervous System Regeneration |
| title_sort | update on graphene based nanomaterials for neural growth and central nervous system regeneration |
| topic | nanomaterials graphene graphene-oxide tissue engineering regenerative medicine |
| url | https://www.mdpi.com/1422-0067/22/23/13047 |
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