Convection Enhanced Delivery of Topotecan for Gliomas: A Single-Center Experience
A key limitation to glioma treatment involves the blood brain barrier (BBB). Convection enhanced delivery (CED) is a technique that uses a catheter placed directly into the brain parenchyma to infuse treatments using a pressure gradient. In this manuscript, we describe the physical principles behind...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-12-01
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| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/13/1/39 |
| _version_ | 1827698970319650816 |
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| author | Pavan S. Upadhyayula Eleonora F. Spinazzi Michael G. Argenziano Peter Canoll Jeffrey N. Bruce |
| author_facet | Pavan S. Upadhyayula Eleonora F. Spinazzi Michael G. Argenziano Peter Canoll Jeffrey N. Bruce |
| author_sort | Pavan S. Upadhyayula |
| collection | DOAJ |
| description | A key limitation to glioma treatment involves the blood brain barrier (BBB). Convection enhanced delivery (CED) is a technique that uses a catheter placed directly into the brain parenchyma to infuse treatments using a pressure gradient. In this manuscript, we describe the physical principles behind CED along with the common pitfalls and methods for optimizing convection. Finally, we highlight our institutional experience using topotecan CED for the treatment of malignant glioma. |
| first_indexed | 2024-03-10T13:40:29Z |
| format | Article |
| id | doaj.art-3933523317a84f3895b8b0bf7135cff9 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T13:40:29Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-3933523317a84f3895b8b0bf7135cff92023-11-21T03:04:52ZengMDPI AGPharmaceutics1999-49232020-12-011313910.3390/pharmaceutics13010039Convection Enhanced Delivery of Topotecan for Gliomas: A Single-Center ExperiencePavan S. Upadhyayula0Eleonora F. Spinazzi1Michael G. Argenziano2Peter Canoll3Jeffrey N. Bruce4Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY 10032, USADepartment of Neurological Surgery, Columbia University Irving Medical Center, New York, NY 10032, USADepartment of Neurological Surgery, Columbia University Irving Medical Center, New York, NY 10032, USADepartment of Cell Biology and Pathology, Columbia University Irving Medical Center, New York, NY 10032, USADepartment of Neurological Surgery, Columbia University Irving Medical Center, New York, NY 10032, USAA key limitation to glioma treatment involves the blood brain barrier (BBB). Convection enhanced delivery (CED) is a technique that uses a catheter placed directly into the brain parenchyma to infuse treatments using a pressure gradient. In this manuscript, we describe the physical principles behind CED along with the common pitfalls and methods for optimizing convection. Finally, we highlight our institutional experience using topotecan CED for the treatment of malignant glioma.https://www.mdpi.com/1999-4923/13/1/39convection enhanced deliverygliomaglioblastomatopotecan |
| spellingShingle | Pavan S. Upadhyayula Eleonora F. Spinazzi Michael G. Argenziano Peter Canoll Jeffrey N. Bruce Convection Enhanced Delivery of Topotecan for Gliomas: A Single-Center Experience Pharmaceutics convection enhanced delivery glioma glioblastoma topotecan |
| title | Convection Enhanced Delivery of Topotecan for Gliomas: A Single-Center Experience |
| title_full | Convection Enhanced Delivery of Topotecan for Gliomas: A Single-Center Experience |
| title_fullStr | Convection Enhanced Delivery of Topotecan for Gliomas: A Single-Center Experience |
| title_full_unstemmed | Convection Enhanced Delivery of Topotecan for Gliomas: A Single-Center Experience |
| title_short | Convection Enhanced Delivery of Topotecan for Gliomas: A Single-Center Experience |
| title_sort | convection enhanced delivery of topotecan for gliomas a single center experience |
| topic | convection enhanced delivery glioma glioblastoma topotecan |
| url | https://www.mdpi.com/1999-4923/13/1/39 |
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