Nutritional Support in Malnourished Children With Compromised Gastrointestinal Function: Utility of Peptide-Based Enteral Therapy
This review focuses on nutritional support in malnourished children with compromised gastrointestinal function addressing the interplay between malnutrition and gastrointestinal dysfunction, and the specific role of peptide-based enteral therapy in pediatric malnutrition. Malnutrition is associated...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-06-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2021.610275/full |
| _version_ | 1818622196762804224 |
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| author | Mukadder Ayse Selimoglu Aydan Kansu Sema Aydogdu Aysugul Alptekin Sarioglu Simge Erdogan Buket Dalgic Aysel Yuce Fugen Cullu Cokugras |
| author_facet | Mukadder Ayse Selimoglu Aydan Kansu Sema Aydogdu Aysugul Alptekin Sarioglu Simge Erdogan Buket Dalgic Aysel Yuce Fugen Cullu Cokugras |
| author_sort | Mukadder Ayse Selimoglu |
| collection | DOAJ |
| description | This review focuses on nutritional support in malnourished children with compromised gastrointestinal function addressing the interplay between malnutrition and gastrointestinal dysfunction, and the specific role of peptide-based enteral therapy in pediatric malnutrition. Malnutrition is associated with impaired gut functions such as increased intestinal permeability, malabsorption, and diarrhea, while pre-existing functional gastrointestinal disorders may also lead to malnutrition. Presence of compromised gastrointestinal function in malnourished children is critical given that alterations such as malabsorption and increased intestinal permeability directly interfere with efficacy of nutritional support and recovery from malnutrition. Appropriate nutritional intervention is the key step in the management of malnutrition, while alterations in gastrointestinal functions in malnourished children are likely even in those with mild degree malnutrition. Therefore, nutritional therapy in children with compromised gastrointestinal function is considered to involve gut-protective interventions that address the overlapping and interacting effects of diarrhea, enteropathy and malnutrition to improve child survival and developmental potential in the long-term. Peptide-based enteral formulas seem to have clinical applications in malnourished children with compromised gastrointestinal function, given their association with improved gastrointestinal tolerance and absorption, better nitrogen retention/ balance, reduced diarrhea and bacterial translocation, enhanced fat absorption, and maintained/restored gut integrity as compared with free amino acid or whole-protein formulas. |
| first_indexed | 2024-12-16T18:21:20Z |
| format | Article |
| id | doaj.art-393410d5082e42e18d06886bd42d3f6e |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-12-16T18:21:20Z |
| publishDate | 2021-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-393410d5082e42e18d06886bd42d3f6e2022-12-21T22:21:33ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602021-06-01910.3389/fped.2021.610275610275Nutritional Support in Malnourished Children With Compromised Gastrointestinal Function: Utility of Peptide-Based Enteral TherapyMukadder Ayse Selimoglu0Aydan Kansu1Sema Aydogdu2Aysugul Alptekin Sarioglu3Simge Erdogan4Buket Dalgic5Aysel Yuce6Fugen Cullu Cokugras7Department of Pediatric Gastroenterology, Atasehir and Bahcelievler Memorial Hospitals, Istanbul, TurkeyDepartment of Pediatric Gastroenterology, Ankara University School of Medicine, Ankara, TurkeyDepartment of Pediatric Gastroenterology, Ege University Faculty of Medicine, Izmir, TurkeyAbbott Laboratories, Istanbul, TurkeyAbbott Laboratories, Istanbul, TurkeyDepartment of Pediatric Gastroenterology, Gazi University Faculty of Medicine, Ankara, TurkeyDepartment of Pediatric Gastroenterology, Hacettepe University Faculty of Medicine, Ankara, TurkeyDepartment of Pediatric Gastroenterology, Istanbul University Cerrahpasa Faculty of Medicine, Istanbul, TurkeyThis review focuses on nutritional support in malnourished children with compromised gastrointestinal function addressing the interplay between malnutrition and gastrointestinal dysfunction, and the specific role of peptide-based enteral therapy in pediatric malnutrition. Malnutrition is associated with impaired gut functions such as increased intestinal permeability, malabsorption, and diarrhea, while pre-existing functional gastrointestinal disorders may also lead to malnutrition. Presence of compromised gastrointestinal function in malnourished children is critical given that alterations such as malabsorption and increased intestinal permeability directly interfere with efficacy of nutritional support and recovery from malnutrition. Appropriate nutritional intervention is the key step in the management of malnutrition, while alterations in gastrointestinal functions in malnourished children are likely even in those with mild degree malnutrition. Therefore, nutritional therapy in children with compromised gastrointestinal function is considered to involve gut-protective interventions that address the overlapping and interacting effects of diarrhea, enteropathy and malnutrition to improve child survival and developmental potential in the long-term. Peptide-based enteral formulas seem to have clinical applications in malnourished children with compromised gastrointestinal function, given their association with improved gastrointestinal tolerance and absorption, better nitrogen retention/ balance, reduced diarrhea and bacterial translocation, enhanced fat absorption, and maintained/restored gut integrity as compared with free amino acid or whole-protein formulas.https://www.frontiersin.org/articles/10.3389/fped.2021.610275/fullmalnutritiongastrointestinal functionchildrennutritional supportmalabsorptiondiarrhea |
| spellingShingle | Mukadder Ayse Selimoglu Aydan Kansu Sema Aydogdu Aysugul Alptekin Sarioglu Simge Erdogan Buket Dalgic Aysel Yuce Fugen Cullu Cokugras Nutritional Support in Malnourished Children With Compromised Gastrointestinal Function: Utility of Peptide-Based Enteral Therapy Frontiers in Pediatrics malnutrition gastrointestinal function children nutritional support malabsorption diarrhea |
| title | Nutritional Support in Malnourished Children With Compromised Gastrointestinal Function: Utility of Peptide-Based Enteral Therapy |
| title_full | Nutritional Support in Malnourished Children With Compromised Gastrointestinal Function: Utility of Peptide-Based Enteral Therapy |
| title_fullStr | Nutritional Support in Malnourished Children With Compromised Gastrointestinal Function: Utility of Peptide-Based Enteral Therapy |
| title_full_unstemmed | Nutritional Support in Malnourished Children With Compromised Gastrointestinal Function: Utility of Peptide-Based Enteral Therapy |
| title_short | Nutritional Support in Malnourished Children With Compromised Gastrointestinal Function: Utility of Peptide-Based Enteral Therapy |
| title_sort | nutritional support in malnourished children with compromised gastrointestinal function utility of peptide based enteral therapy |
| topic | malnutrition gastrointestinal function children nutritional support malabsorption diarrhea |
| url | https://www.frontiersin.org/articles/10.3389/fped.2021.610275/full |
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