Missing <i>lnc</i>(RNAs) in Alzheimer’s Disease?
With the ongoing demographic shift towards increasingly elderly populations, it is estimated that approximately 150 million people will live with Alzheimer’s disease (AD) by 2050. By then, AD will be one of the most burdensome diseases of this and potentially next centuries. Although its exact etiol...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Genes |
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| Online Access: | https://www.mdpi.com/2073-4425/13/1/39 |
| _version_ | 1797493835776917504 |
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| author | Rafaela Policarpo Constantin d’Ydewalle |
| author_facet | Rafaela Policarpo Constantin d’Ydewalle |
| author_sort | Rafaela Policarpo |
| collection | DOAJ |
| description | With the ongoing demographic shift towards increasingly elderly populations, it is estimated that approximately 150 million people will live with Alzheimer’s disease (AD) by 2050. By then, AD will be one of the most burdensome diseases of this and potentially next centuries. Although its exact etiology remains elusive, both environmental and genetic factors play crucial roles in the mechanisms underlying AD neuropathology. Genome-wide association studies (GWAS) identified genetic variants associated with AD susceptibility in more than 40 different genomic loci. Most of these disease-associated variants reside in non-coding regions of the genome. In recent years, it has become clear that functionally active transcripts arise from these non-coding loci. One type of non-coding transcript, referred to as long non-coding RNAs (lncRNAs), gained significant attention due to their multiple roles in neurodevelopment, brain homeostasis, aging, and their dysregulation or dysfunction in neurological diseases including in AD. Here, we will summarize the current knowledge regarding genetic variations, expression profiles, as well as potential functions, diagnostic or therapeutic roles of lncRNAs in AD. We postulate that lncRNAs may represent the missing link in AD pathology and that unraveling their role may open avenues to better AD treatments. |
| first_indexed | 2024-03-10T01:25:40Z |
| format | Article |
| id | doaj.art-3934a5487f774952b85fd022422385f7 |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-10T01:25:40Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-3934a5487f774952b85fd022422385f72023-11-23T13:51:19ZengMDPI AGGenes2073-44252021-12-011313910.3390/genes13010039Missing <i>lnc</i>(RNAs) in Alzheimer’s Disease?Rafaela Policarpo0Constantin d’Ydewalle1VIB-KU Leuven Center for Brain & Disease Research, 3000 Leuven, BelgiumNeuroscience Discovery, Janssen Research & Development, Janssen Pharmaceutica N.V., 2340 Beerse, BelgiumWith the ongoing demographic shift towards increasingly elderly populations, it is estimated that approximately 150 million people will live with Alzheimer’s disease (AD) by 2050. By then, AD will be one of the most burdensome diseases of this and potentially next centuries. Although its exact etiology remains elusive, both environmental and genetic factors play crucial roles in the mechanisms underlying AD neuropathology. Genome-wide association studies (GWAS) identified genetic variants associated with AD susceptibility in more than 40 different genomic loci. Most of these disease-associated variants reside in non-coding regions of the genome. In recent years, it has become clear that functionally active transcripts arise from these non-coding loci. One type of non-coding transcript, referred to as long non-coding RNAs (lncRNAs), gained significant attention due to their multiple roles in neurodevelopment, brain homeostasis, aging, and their dysregulation or dysfunction in neurological diseases including in AD. Here, we will summarize the current knowledge regarding genetic variations, expression profiles, as well as potential functions, diagnostic or therapeutic roles of lncRNAs in AD. We postulate that lncRNAs may represent the missing link in AD pathology and that unraveling their role may open avenues to better AD treatments.https://www.mdpi.com/2073-4425/13/1/39Alzheimer’s diseaselong non-coding RNAsgene expression |
| spellingShingle | Rafaela Policarpo Constantin d’Ydewalle Missing <i>lnc</i>(RNAs) in Alzheimer’s Disease? Genes Alzheimer’s disease long non-coding RNAs gene expression |
| title | Missing <i>lnc</i>(RNAs) in Alzheimer’s Disease? |
| title_full | Missing <i>lnc</i>(RNAs) in Alzheimer’s Disease? |
| title_fullStr | Missing <i>lnc</i>(RNAs) in Alzheimer’s Disease? |
| title_full_unstemmed | Missing <i>lnc</i>(RNAs) in Alzheimer’s Disease? |
| title_short | Missing <i>lnc</i>(RNAs) in Alzheimer’s Disease? |
| title_sort | missing i lnc i rnas in alzheimer s disease |
| topic | Alzheimer’s disease long non-coding RNAs gene expression |
| url | https://www.mdpi.com/2073-4425/13/1/39 |
| work_keys_str_mv | AT rafaelapolicarpo missingilncirnasinalzheimersdisease AT constantindydewalle missingilncirnasinalzheimersdisease |