Molecular evolution and diversification of the GRF transcription factor family
Abstract - Growth Regulating Factors (GRFs) comprise a transcription factor family with important functions in plant growth and development. They are characterized by the presence of QLQ and WRC domains, responsible for interaction with proteins and DNA, respectively. The QLQ domain is named due to...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Genética
2020-07-01
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| Series: | Genetics and Molecular Biology |
| Subjects: | |
| Online Access: | http://www.scielo.br/pdf/gmb/v43n3/1415-4757-GMB-43-3-e20200080.pdf |
| _version_ | 1798032689621630976 |
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| author | Leila Spagnolo Fonini Fernanda Lazzarotto Pedro M. Barros Caroline Cabreira-Cagliari Marcelo Affonso Begossi Martins Nelson J.M. Saibo Andreia Carina Turchetto-Zolet Marcia Margis-Pinheiro |
| author_facet | Leila Spagnolo Fonini Fernanda Lazzarotto Pedro M. Barros Caroline Cabreira-Cagliari Marcelo Affonso Begossi Martins Nelson J.M. Saibo Andreia Carina Turchetto-Zolet Marcia Margis-Pinheiro |
| author_sort | Leila Spagnolo Fonini |
| collection | DOAJ |
| description | Abstract - Growth Regulating Factors (GRFs) comprise a transcription factor family with important functions in plant growth and development. They are characterized by the presence of QLQ and WRC domains, responsible for interaction with proteins and DNA, respectively. The QLQ domain is named due to the similarity to a protein interaction domain found in the SWI2/SNF2 chromatin remodeling complex. Despite the occurrence of the QLQ domain in both families, the divergence between them had not been further explored. Here, we show evidence for GRF origin and determined its diversification in angiosperm species. Phylogenetic analysis revealed 11 well-supported groups of GRFs in flowering plants. These groups were supported by gene structure, synteny, and protein domain composition. Synteny and phylogenetic analyses allowed us to propose different sets of probable orthologs in the groups. Besides, our results, together with functional data previously published, allowed us to suggest candidate genes for engineering agronomic traits. In addition, we propose that the QLQ domain of GRF genes evolved from the eukaryotic SNF2 QLQ domain, most likely by a duplication event in the common ancestor of the Charophytes and land plants. Altogether, our results are important for advancing the origin and evolution of the GRF family in Streptophyta. |
| first_indexed | 2024-04-11T20:16:49Z |
| format | Article |
| id | doaj.art-3934fa77abce4d658144a9198811d767 |
| institution | Directory Open Access Journal |
| issn | 1678-4685 |
| language | English |
| last_indexed | 2024-04-11T20:16:49Z |
| publishDate | 2020-07-01 |
| publisher | Sociedade Brasileira de Genética |
| record_format | Article |
| series | Genetics and Molecular Biology |
| spelling | doaj.art-3934fa77abce4d658144a9198811d7672022-12-22T04:04:55ZengSociedade Brasileira de GenéticaGenetics and Molecular Biology1678-46852020-07-0143310.1590/1678-4685-gmb-2020-0080Molecular evolution and diversification of the GRF transcription factor familyLeila Spagnolo FoniniFernanda LazzarottoPedro M. BarrosCaroline Cabreira-CagliariMarcelo Affonso Begossi MartinsNelson J.M. Saibohttps://orcid.org/0000-0002-6679-3811Andreia Carina Turchetto-Zolethttps://orcid.org/0000-0002-7365-1360Marcia Margis-PinheiroAbstract - Growth Regulating Factors (GRFs) comprise a transcription factor family with important functions in plant growth and development. They are characterized by the presence of QLQ and WRC domains, responsible for interaction with proteins and DNA, respectively. The QLQ domain is named due to the similarity to a protein interaction domain found in the SWI2/SNF2 chromatin remodeling complex. Despite the occurrence of the QLQ domain in both families, the divergence between them had not been further explored. Here, we show evidence for GRF origin and determined its diversification in angiosperm species. Phylogenetic analysis revealed 11 well-supported groups of GRFs in flowering plants. These groups were supported by gene structure, synteny, and protein domain composition. Synteny and phylogenetic analyses allowed us to propose different sets of probable orthologs in the groups. Besides, our results, together with functional data previously published, allowed us to suggest candidate genes for engineering agronomic traits. In addition, we propose that the QLQ domain of GRF genes evolved from the eukaryotic SNF2 QLQ domain, most likely by a duplication event in the common ancestor of the Charophytes and land plants. Altogether, our results are important for advancing the origin and evolution of the GRF family in Streptophyta.http://www.scielo.br/pdf/gmb/v43n3/1415-4757-GMB-43-3-e20200080.pdfGRFmolecular evolutionQLQ domainBayesian analysis |
| spellingShingle | Leila Spagnolo Fonini Fernanda Lazzarotto Pedro M. Barros Caroline Cabreira-Cagliari Marcelo Affonso Begossi Martins Nelson J.M. Saibo Andreia Carina Turchetto-Zolet Marcia Margis-Pinheiro Molecular evolution and diversification of the GRF transcription factor family Genetics and Molecular Biology GRF molecular evolution QLQ domain Bayesian analysis |
| title | Molecular evolution and diversification of the GRF transcription factor family |
| title_full | Molecular evolution and diversification of the GRF transcription factor family |
| title_fullStr | Molecular evolution and diversification of the GRF transcription factor family |
| title_full_unstemmed | Molecular evolution and diversification of the GRF transcription factor family |
| title_short | Molecular evolution and diversification of the GRF transcription factor family |
| title_sort | molecular evolution and diversification of the grf transcription factor family |
| topic | GRF molecular evolution QLQ domain Bayesian analysis |
| url | http://www.scielo.br/pdf/gmb/v43n3/1415-4757-GMB-43-3-e20200080.pdf |
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