Study of Acid-related Disorders: Real-world Physician and Patient Perspectives on Burden of Helicobacter pylori Infection
Background and Aims: Helicobacter pylori eradication rates have declined as antibiotic resistance rates have increased. In addition, adherence to treatment guidelines is suboptimal. It is therefore important that contemporary, real-world evidence of diagnostic and treatment patterns is explored and...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | Gastro Hep Advances |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772572321000418 |
| _version_ | 1811280280891162624 |
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| author | Colin W. Howden Stuart J. Spechler Michael F. Vaezi A. Mark Fendrick Christian Atkinson Corey Pelletier Rinu Jacob Stephen Brunton |
| author_facet | Colin W. Howden Stuart J. Spechler Michael F. Vaezi A. Mark Fendrick Christian Atkinson Corey Pelletier Rinu Jacob Stephen Brunton |
| author_sort | Colin W. Howden |
| collection | DOAJ |
| description | Background and Aims: Helicobacter pylori eradication rates have declined as antibiotic resistance rates have increased. In addition, adherence to treatment guidelines is suboptimal. It is therefore important that contemporary, real-world evidence of diagnostic and treatment patterns is explored and compared with evidence-based guidelines. The Study of Acid-Related Disorders investigated unmet needs among patients with H pylori infection and past or current dyspepsia. Methods: Gastroenterologists (GIs) and family physicians (FPs) or general practitioners (GPs) treating patients with H pylori infection and past or current dyspepsia completed a physician survey and invited patients to complete a patient survey; data were also extracted from the medical records of enrolled patients. Results: Two hundred fifty-one physicians and 77 patients were enrolled. A total of 19.5% of patients were diagnosed by serology, whereas the urea breath test was used by 6.5% of GIs and 50.0% of FPs or GPs. A total of 68.6% of GIs and 79.8% of FPs or GPs selected clarithromycin, amoxicillin, and proton pump inhibitor triple therapy as their ideal first-line treatment. Physicians reported that 52.9% of patients experienced dyspepsia daily. A total of 46.8% of patients believed that complete resolution of dyspepsia would indicate effective treatment. As their treatment goal, 69.3% of physicians selected improvement in overall symptoms, whereas 92.2% of patients specified improvement in dyspepsia. Only 28.7% of physicians were satisfied with current treatment options. A total of 59.7% of patients took all of their prescribed medicine(s). A total of 59.7% of patients would prefer to take fewer pills; 45.5% would prefer convenience packs. Conclusion: This study reveals a lack of adherence to current H pylori guidelines for diagnosis, testing, and treatment. New treatment options that are more efficacious and simpler for patients to adhere to are needed. |
| first_indexed | 2024-04-13T01:10:48Z |
| format | Article |
| id | doaj.art-39375afa12d14f2dae5434725d2f863a |
| institution | Directory Open Access Journal |
| issn | 2772-5723 |
| language | English |
| last_indexed | 2024-04-13T01:10:48Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Gastro Hep Advances |
| spelling | doaj.art-39375afa12d14f2dae5434725d2f863a2022-12-22T03:09:09ZengElsevierGastro Hep Advances2772-57232022-01-0112231240Study of Acid-related Disorders: Real-world Physician and Patient Perspectives on Burden of Helicobacter pylori InfectionColin W. Howden0Stuart J. Spechler1Michael F. Vaezi2A. Mark Fendrick3Christian Atkinson4Corey Pelletier5Rinu Jacob6Stephen Brunton7University of Tennessee Health Science Center, Memphis, TN; Correspondence: Address correspondence to: Colin W. Howden, MD, University of Tennessee Health Science Center, Memphis, TN.Department of Medicine, Baylor University Medical Center and Center for Esophageal Research, Baylor Scott & White Research Institute, Dallas, TXDivision of Gastroenterology, Hepatology, and Nutrition, Center for Swallowing and Esophageal Disorders, Vanderbilt University Medical Center, Nashville, TNDivision of General Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, MIAdelphi Real World, Bollington, UKPhathom Pharmaceuticals, Florham Park, NJPhathom Pharmaceuticals, Florham Park, NJPrimary Care Education Consortium, Winnsboro, SCBackground and Aims: Helicobacter pylori eradication rates have declined as antibiotic resistance rates have increased. In addition, adherence to treatment guidelines is suboptimal. It is therefore important that contemporary, real-world evidence of diagnostic and treatment patterns is explored and compared with evidence-based guidelines. The Study of Acid-Related Disorders investigated unmet needs among patients with H pylori infection and past or current dyspepsia. Methods: Gastroenterologists (GIs) and family physicians (FPs) or general practitioners (GPs) treating patients with H pylori infection and past or current dyspepsia completed a physician survey and invited patients to complete a patient survey; data were also extracted from the medical records of enrolled patients. Results: Two hundred fifty-one physicians and 77 patients were enrolled. A total of 19.5% of patients were diagnosed by serology, whereas the urea breath test was used by 6.5% of GIs and 50.0% of FPs or GPs. A total of 68.6% of GIs and 79.8% of FPs or GPs selected clarithromycin, amoxicillin, and proton pump inhibitor triple therapy as their ideal first-line treatment. Physicians reported that 52.9% of patients experienced dyspepsia daily. A total of 46.8% of patients believed that complete resolution of dyspepsia would indicate effective treatment. As their treatment goal, 69.3% of physicians selected improvement in overall symptoms, whereas 92.2% of patients specified improvement in dyspepsia. Only 28.7% of physicians were satisfied with current treatment options. A total of 59.7% of patients took all of their prescribed medicine(s). A total of 59.7% of patients would prefer to take fewer pills; 45.5% would prefer convenience packs. Conclusion: This study reveals a lack of adherence to current H pylori guidelines for diagnosis, testing, and treatment. New treatment options that are more efficacious and simpler for patients to adhere to are needed.http://www.sciencedirect.com/science/article/pii/S2772572321000418Helicobacter pyloriReal-World EvidenceSatisfactionAdherenceDyspepsia. |
| spellingShingle | Colin W. Howden Stuart J. Spechler Michael F. Vaezi A. Mark Fendrick Christian Atkinson Corey Pelletier Rinu Jacob Stephen Brunton Study of Acid-related Disorders: Real-world Physician and Patient Perspectives on Burden of Helicobacter pylori Infection Gastro Hep Advances Helicobacter pylori Real-World Evidence Satisfaction Adherence Dyspepsia. |
| title | Study of Acid-related Disorders: Real-world Physician and Patient Perspectives on Burden of Helicobacter pylori Infection |
| title_full | Study of Acid-related Disorders: Real-world Physician and Patient Perspectives on Burden of Helicobacter pylori Infection |
| title_fullStr | Study of Acid-related Disorders: Real-world Physician and Patient Perspectives on Burden of Helicobacter pylori Infection |
| title_full_unstemmed | Study of Acid-related Disorders: Real-world Physician and Patient Perspectives on Burden of Helicobacter pylori Infection |
| title_short | Study of Acid-related Disorders: Real-world Physician and Patient Perspectives on Burden of Helicobacter pylori Infection |
| title_sort | study of acid related disorders real world physician and patient perspectives on burden of helicobacter pylori infection |
| topic | Helicobacter pylori Real-World Evidence Satisfaction Adherence Dyspepsia. |
| url | http://www.sciencedirect.com/science/article/pii/S2772572321000418 |
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