Prenylated Xanthones from the Bark of Garcinia xanthochymus and Their 1,1-Diphenyl-2-picrylhydrazyl (DPPH) Radical Scavenging Activities
Garcinia xanthochymus has been widely used in traditional Chinese medicine for expelling worms and removing food toxins. Bioassay-guided fractionation of an EtOAc-soluble extract of G. xanthochymus stem bark led to the isolation of six new xanthones. Their structures were elucidated by spectroscopic...
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MDPI AG
2010-10-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/15/10/7438/ |
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| author | Hong-wu He Fang-fang Zhong Guang-zhong Yang Yu Chen Hua Fan Yan Jiang |
| author_facet | Hong-wu He Fang-fang Zhong Guang-zhong Yang Yu Chen Hua Fan Yan Jiang |
| author_sort | Hong-wu He |
| collection | DOAJ |
| description | Garcinia xanthochymus has been widely used in traditional Chinese medicine for expelling worms and removing food toxins. Bioassay-guided fractionation of an EtOAc-soluble extract of G. xanthochymus stem bark led to the isolation of six new xanthones. Their structures were elucidated by spectroscopic methods, especially 2D-NMR techniques. Free-radical-scavenging activities of the isolated compounds were elucidated through DPPH method. Most of the isolated compounds showed considerable free radical scavenging activity on DPPH assay. Compound 1 exhibited effective antioxidant scavenging activity against DPPH radical with an IC50 value of 19.64 μM, and compound 6 showed the lowest activity among all the tested molecules, with an IC50 value of 66.88 μM. These findings support the notion that the plant genus Garcinia is a good source of bioactive compounds. |
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| id | doaj.art-3938d3597f2749c7bc3ffdc351827f9b |
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| issn | 1420-3049 |
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| spelling | doaj.art-3938d3597f2749c7bc3ffdc351827f9b2022-12-21T21:48:44ZengMDPI AGMolecules1420-30492010-10-0115107438744910.3390/molecules15107438Prenylated Xanthones from the Bark of Garcinia xanthochymus and Their 1,1-Diphenyl-2-picrylhydrazyl (DPPH) Radical Scavenging ActivitiesHong-wu HeFang-fang ZhongGuang-zhong YangYu ChenHua FanYan JiangGarcinia xanthochymus has been widely used in traditional Chinese medicine for expelling worms and removing food toxins. Bioassay-guided fractionation of an EtOAc-soluble extract of G. xanthochymus stem bark led to the isolation of six new xanthones. Their structures were elucidated by spectroscopic methods, especially 2D-NMR techniques. Free-radical-scavenging activities of the isolated compounds were elucidated through DPPH method. Most of the isolated compounds showed considerable free radical scavenging activity on DPPH assay. Compound 1 exhibited effective antioxidant scavenging activity against DPPH radical with an IC50 value of 19.64 μM, and compound 6 showed the lowest activity among all the tested molecules, with an IC50 value of 66.88 μM. These findings support the notion that the plant genus Garcinia is a good source of bioactive compounds.http://www.mdpi.com/1420-3049/15/10/7438/XanthonesGarcinia xanthochymusDPPH radical scavenging activity |
| spellingShingle | Hong-wu He Fang-fang Zhong Guang-zhong Yang Yu Chen Hua Fan Yan Jiang Prenylated Xanthones from the Bark of Garcinia xanthochymus and Their 1,1-Diphenyl-2-picrylhydrazyl (DPPH) Radical Scavenging Activities Molecules Xanthones Garcinia xanthochymus DPPH radical scavenging activity |
| title | Prenylated Xanthones from the Bark of Garcinia xanthochymus and Their 1,1-Diphenyl-2-picrylhydrazyl (DPPH) Radical Scavenging Activities |
| title_full | Prenylated Xanthones from the Bark of Garcinia xanthochymus and Their 1,1-Diphenyl-2-picrylhydrazyl (DPPH) Radical Scavenging Activities |
| title_fullStr | Prenylated Xanthones from the Bark of Garcinia xanthochymus and Their 1,1-Diphenyl-2-picrylhydrazyl (DPPH) Radical Scavenging Activities |
| title_full_unstemmed | Prenylated Xanthones from the Bark of Garcinia xanthochymus and Their 1,1-Diphenyl-2-picrylhydrazyl (DPPH) Radical Scavenging Activities |
| title_short | Prenylated Xanthones from the Bark of Garcinia xanthochymus and Their 1,1-Diphenyl-2-picrylhydrazyl (DPPH) Radical Scavenging Activities |
| title_sort | prenylated xanthones from the bark of garcinia xanthochymus and their 1 1 diphenyl 2 picrylhydrazyl dpph radical scavenging activities |
| topic | Xanthones Garcinia xanthochymus DPPH radical scavenging activity |
| url | http://www.mdpi.com/1420-3049/15/10/7438/ |
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