Maternal Dietary Patterns during Pregnancy and Child Autism-Related Traits: Results from Two US Cohorts
We examined the relationship between maternal intake of established dietary patterns and child autism-related outcomes in two prospective cohorts in the United States. Participants were drawn from the Early Autism Risk Longitudinal Investigation (EARLI, <i>n</i> = 154) and the Nurses’ He...
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MDPI AG
2022-06-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/13/2729 |
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| author | Rachel Vecchione Siwen Wang Juliette Rando Jorge E. Chavarro Lisa A. Croen M. Daniele Fallin Irva Hertz-Picciotto Craig J. Newschaffer Rebecca J. Schmidt Kristen Lyall |
| author_facet | Rachel Vecchione Siwen Wang Juliette Rando Jorge E. Chavarro Lisa A. Croen M. Daniele Fallin Irva Hertz-Picciotto Craig J. Newschaffer Rebecca J. Schmidt Kristen Lyall |
| author_sort | Rachel Vecchione |
| collection | DOAJ |
| description | We examined the relationship between maternal intake of established dietary patterns and child autism-related outcomes in two prospective cohorts in the United States. Participants were drawn from the Early Autism Risk Longitudinal Investigation (EARLI, <i>n</i> = 154) and the Nurses’ Health Study II (NHSII, <i>n</i> = 727). Dietary information was collected via food frequency questionnaires (FFQs) and used to calculate the empirical dietary inflammatory pattern (EDIP), Alternative Healthy Eating Index (AHEI), Western and Prudent dietary patterns, and the alternative Mediterranean Diet (aMED) score. Primary analyses examined associations with continuous autism-related traits as measured by the Social Responsiveness Scale (SRS), and secondary analyses with autism spectrum disorder (ASD) diagnosis. We used crude and multivariable quantile regression fixed at the 50th percentile to examine associations between quartiles of dietary patterns and SRS scores, and logistic regression to examine associations with ASD diagnosis. There was suggestion of a positive association with the Western diet (Q4 vs. Q1, ß = 11.19, 95% CI: 3.30, 19.90) in EARLI, though the association was attenuated with adjustment for total energy intake, and no clear associations were observed with other dietary patterns and ASD diagnosis or SRS scores. Further work is needed to better understand the role of maternal dietary patterns in ASD and related outcomes. |
| first_indexed | 2024-03-09T10:26:19Z |
| format | Article |
| id | doaj.art-3938f4341ff2456f843a7f47da25cf9f |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T10:26:19Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-3938f4341ff2456f843a7f47da25cf9f2023-12-01T21:38:25ZengMDPI AGNutrients2072-66432022-06-011413272910.3390/nu14132729Maternal Dietary Patterns during Pregnancy and Child Autism-Related Traits: Results from Two US CohortsRachel Vecchione0Siwen Wang1Juliette Rando2Jorge E. Chavarro3Lisa A. Croen4M. Daniele Fallin5Irva Hertz-Picciotto6Craig J. Newschaffer7Rebecca J. Schmidt8Kristen Lyall9Department of Epidemiology and Biostatistics, Dornsife School of Public Health, Drexel University, Philadelphia, PA 19104, USADepartment of Nutrition, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA 02215, USAAJ Drexel Autism Institute, Drexel University, Philadelphia, PA 19104, USADepartment of Nutrition, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA 02215, USADivision of Research, Kaiser Permanente Norther California, Oakland, CA 94612, USADepartment of Mental Health, Johns Hopkins, Baltimore, MD 21205, USADepartment of Public Health Sciences, University of California Davis, Davis, CA 95616, USACollege of Health and Human Development, Pennsylvania State University, State College, PA 16801, USADepartment of Public Health Sciences, University of California Davis, Davis, CA 95616, USADepartment of Epidemiology and Biostatistics, Dornsife School of Public Health, Drexel University, Philadelphia, PA 19104, USAWe examined the relationship between maternal intake of established dietary patterns and child autism-related outcomes in two prospective cohorts in the United States. Participants were drawn from the Early Autism Risk Longitudinal Investigation (EARLI, <i>n</i> = 154) and the Nurses’ Health Study II (NHSII, <i>n</i> = 727). Dietary information was collected via food frequency questionnaires (FFQs) and used to calculate the empirical dietary inflammatory pattern (EDIP), Alternative Healthy Eating Index (AHEI), Western and Prudent dietary patterns, and the alternative Mediterranean Diet (aMED) score. Primary analyses examined associations with continuous autism-related traits as measured by the Social Responsiveness Scale (SRS), and secondary analyses with autism spectrum disorder (ASD) diagnosis. We used crude and multivariable quantile regression fixed at the 50th percentile to examine associations between quartiles of dietary patterns and SRS scores, and logistic regression to examine associations with ASD diagnosis. There was suggestion of a positive association with the Western diet (Q4 vs. Q1, ß = 11.19, 95% CI: 3.30, 19.90) in EARLI, though the association was attenuated with adjustment for total energy intake, and no clear associations were observed with other dietary patterns and ASD diagnosis or SRS scores. Further work is needed to better understand the role of maternal dietary patterns in ASD and related outcomes.https://www.mdpi.com/2072-6643/14/13/2729dietary patternsautism spectrum disorderssocial responsiveness scaleAHEI-2010AHEI-PEDIP |
| spellingShingle | Rachel Vecchione Siwen Wang Juliette Rando Jorge E. Chavarro Lisa A. Croen M. Daniele Fallin Irva Hertz-Picciotto Craig J. Newschaffer Rebecca J. Schmidt Kristen Lyall Maternal Dietary Patterns during Pregnancy and Child Autism-Related Traits: Results from Two US Cohorts Nutrients dietary patterns autism spectrum disorders social responsiveness scale AHEI-2010 AHEI-P EDIP |
| title | Maternal Dietary Patterns during Pregnancy and Child Autism-Related Traits: Results from Two US Cohorts |
| title_full | Maternal Dietary Patterns during Pregnancy and Child Autism-Related Traits: Results from Two US Cohorts |
| title_fullStr | Maternal Dietary Patterns during Pregnancy and Child Autism-Related Traits: Results from Two US Cohorts |
| title_full_unstemmed | Maternal Dietary Patterns during Pregnancy and Child Autism-Related Traits: Results from Two US Cohorts |
| title_short | Maternal Dietary Patterns during Pregnancy and Child Autism-Related Traits: Results from Two US Cohorts |
| title_sort | maternal dietary patterns during pregnancy and child autism related traits results from two us cohorts |
| topic | dietary patterns autism spectrum disorders social responsiveness scale AHEI-2010 AHEI-P EDIP |
| url | https://www.mdpi.com/2072-6643/14/13/2729 |
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