Acute gastroenteritis-related acute kidney injury in a tertiary care center
BACKGROUND: Acute gastroenteritis (AGE) can cause acute kidney injury (AKI) via hypoperfusion mechanisms. Early detection of AKI caused by AGE can significantly decrease mortality rates. In Saudi Arabia, studies investigating the association between AGE and AKI are limited; thus, we aimed to fill th...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
King Faisal Specialist Hospital and Research Centre
2023-03-01
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| Series: | Annals of Saudi Medicine |
| Online Access: | http://www.annsaudimed.net/doi/10.5144/0256-4947.2023.82 |
| _version_ | 1797850221145751552 |
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| author | Mohammed Hisham Bogari Adeeb Munshi Saleh Almuntashiri Asim Bogari Abdullah Shaker Abdullah Mohammed Albadri Ameer Hashim Mohammed Saeed AlZahrani |
| author_facet | Mohammed Hisham Bogari Adeeb Munshi Saleh Almuntashiri Asim Bogari Abdullah Shaker Abdullah Mohammed Albadri Ameer Hashim Mohammed Saeed AlZahrani |
| author_sort | Mohammed Hisham Bogari |
| collection | DOAJ |
| description | BACKGROUND: Acute gastroenteritis (AGE) can cause acute kidney injury (AKI) via hypoperfusion mechanisms. Early detection of AKI caused by AGE can significantly decrease mortality rates. In Saudi Arabia, studies investigating the association between AGE and AKI are limited; thus, we aimed to fill this knowledge gap. OBJECTIVES: Analyze all cases of AGE reported in tertiary-care hospitals to assess the prevalence of AKI among AGE patients. DESIGN: Retrospective cohort SETTINGS: Single tertiary-care center PATIENTS AND METHODS: The study included patients treated for AGE between October 2017 and October 2022. Stool culture was used to diagnose AGE. Inclusion criteria were infective diarrhea and/ or vomiting, and availability of data (demographics, comorbidities, malignancies, length of hospital stay, vital signs at the time of diagnosis, dehydration, causative agents of diarrhea, hemodialysis status, and laboratory data. MAIN OUTCOME MEASURES: Prevalence of AKI among AGE patients and factors associated with development of AKI. SAMPLE SIZE: 300 patients diagnosed with AGE. RESULTS: Of the 300 patients with AGE, 41 (13.6%) had AKI, those older than 60 years were more likely to develop AKI. The most frequent cause of AGE was Salmonella spp. (n=163, 53.3%), whereas AKI was most common in Clostridium difficile AGE patients (n=21, 51.2%). Furthermore, the most common comorbidity in the present study was malignancy, especially leukemia and lymphoma the risk of AKI was independently associated with mild dehydration, higher serum urea concentrations and low GFR values. CONCLUSIONS: Patients hospitalized for diarrheal disease are at an increased risk of developing AKI due to dehydration and comorbid conditions. It is crucial to keep kidney function in mind for AGE patients as this is associated with a high mortality rate and poor prognosis. LIMITATIONS: The main limitation of this study was its retrospective design. Another limitation is that it is limited to a single center. CONFLICTS OF INTEREST: None. |
| first_indexed | 2024-04-09T18:56:54Z |
| format | Article |
| id | doaj.art-39396aee129b449ab1af1e2ae7d05a48 |
| institution | Directory Open Access Journal |
| issn | 0256-4947 0975-4466 |
| language | English |
| last_indexed | 2024-04-09T18:56:54Z |
| publishDate | 2023-03-01 |
| publisher | King Faisal Specialist Hospital and Research Centre |
| record_format | Article |
| series | Annals of Saudi Medicine |
| spelling | doaj.art-39396aee129b449ab1af1e2ae7d05a482023-04-09T09:21:42ZengKing Faisal Specialist Hospital and Research CentreAnnals of Saudi Medicine0256-49470975-44662023-03-01432828910.5144/0256-4947.2023.82Acute gastroenteritis-related acute kidney injury in a tertiary care centerMohammed Hisham Bogari0Adeeb Munshi1Saleh Almuntashiri2Asim Bogari3Abdullah Shaker Abdullah4Mohammed Albadri5Ameer Hashim6Mohammed Saeed AlZahrani7From the College of Medicine, King Saud Abdulaziz University for Health Sciences, Jeddah, Saudi ArabiaFrom the Department of Infectious Diseases, King Abdulaziz Medical City, Jeddah, Saudi ArabiaFrom the College of Medicine, King Saud Abdulaziz University for Health Sciences, Jeddah, Saudi ArabiaFrom the College of Medicine, King Saud Abdulaziz University for Health Sciences, Jeddah, Saudi ArabiaFrom the College of Medicine, King Saud Abdulaziz University for Health Sciences, Jeddah, Saudi ArabiaFrom the College of Medicine, King Saud Abdulaziz University for Health Sciences, Jeddah, Saudi ArabiaFrom the Department of Internal Medicine, Makkah Al-Mukarramah Region General Directorate of Health Affairs, Makkah, Saudi ArabiaFrom the Department of Infectious Diseases, King Abdulaziz Medical City, Jeddah, Saudi ArabiaBACKGROUND: Acute gastroenteritis (AGE) can cause acute kidney injury (AKI) via hypoperfusion mechanisms. Early detection of AKI caused by AGE can significantly decrease mortality rates. In Saudi Arabia, studies investigating the association between AGE and AKI are limited; thus, we aimed to fill this knowledge gap. OBJECTIVES: Analyze all cases of AGE reported in tertiary-care hospitals to assess the prevalence of AKI among AGE patients. DESIGN: Retrospective cohort SETTINGS: Single tertiary-care center PATIENTS AND METHODS: The study included patients treated for AGE between October 2017 and October 2022. Stool culture was used to diagnose AGE. Inclusion criteria were infective diarrhea and/ or vomiting, and availability of data (demographics, comorbidities, malignancies, length of hospital stay, vital signs at the time of diagnosis, dehydration, causative agents of diarrhea, hemodialysis status, and laboratory data. MAIN OUTCOME MEASURES: Prevalence of AKI among AGE patients and factors associated with development of AKI. SAMPLE SIZE: 300 patients diagnosed with AGE. RESULTS: Of the 300 patients with AGE, 41 (13.6%) had AKI, those older than 60 years were more likely to develop AKI. The most frequent cause of AGE was Salmonella spp. (n=163, 53.3%), whereas AKI was most common in Clostridium difficile AGE patients (n=21, 51.2%). Furthermore, the most common comorbidity in the present study was malignancy, especially leukemia and lymphoma the risk of AKI was independently associated with mild dehydration, higher serum urea concentrations and low GFR values. CONCLUSIONS: Patients hospitalized for diarrheal disease are at an increased risk of developing AKI due to dehydration and comorbid conditions. It is crucial to keep kidney function in mind for AGE patients as this is associated with a high mortality rate and poor prognosis. LIMITATIONS: The main limitation of this study was its retrospective design. Another limitation is that it is limited to a single center. CONFLICTS OF INTEREST: None.http://www.annsaudimed.net/doi/10.5144/0256-4947.2023.82 |
| spellingShingle | Mohammed Hisham Bogari Adeeb Munshi Saleh Almuntashiri Asim Bogari Abdullah Shaker Abdullah Mohammed Albadri Ameer Hashim Mohammed Saeed AlZahrani Acute gastroenteritis-related acute kidney injury in a tertiary care center Annals of Saudi Medicine |
| title | Acute gastroenteritis-related acute kidney injury in a tertiary care center |
| title_full | Acute gastroenteritis-related acute kidney injury in a tertiary care center |
| title_fullStr | Acute gastroenteritis-related acute kidney injury in a tertiary care center |
| title_full_unstemmed | Acute gastroenteritis-related acute kidney injury in a tertiary care center |
| title_short | Acute gastroenteritis-related acute kidney injury in a tertiary care center |
| title_sort | acute gastroenteritis related acute kidney injury in a tertiary care center |
| url | http://www.annsaudimed.net/doi/10.5144/0256-4947.2023.82 |
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