Self-propelled assembly of nanoparticles with self-catalytic regulation for tumour-specific imaging and therapy
Abstract Targeted assembly of nanoparticles in biological systems holds great promise for disease-specific imaging and therapy. However, the current manipulation of nanoparticle dynamics is primarily limited to organic pericyclic reactions, which necessitate the introduction of synthetic functional...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-024-44736-y |
| _version_ | 1797355632912760832 |
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| author | Mengmeng Xia Qiyue Wang Yamin Liu Chunyan Fang Bo Zhang Shengfei Yang Fu Zhou Peihua Lin Mingzheng Gu Canyu Huang Xiaojun Zhang Fangyuan Li Hongying Liu Guangfeng Wang Daishun Ling |
| author_facet | Mengmeng Xia Qiyue Wang Yamin Liu Chunyan Fang Bo Zhang Shengfei Yang Fu Zhou Peihua Lin Mingzheng Gu Canyu Huang Xiaojun Zhang Fangyuan Li Hongying Liu Guangfeng Wang Daishun Ling |
| author_sort | Mengmeng Xia |
| collection | DOAJ |
| description | Abstract Targeted assembly of nanoparticles in biological systems holds great promise for disease-specific imaging and therapy. However, the current manipulation of nanoparticle dynamics is primarily limited to organic pericyclic reactions, which necessitate the introduction of synthetic functional groups as bioorthogonal handles on the nanoparticles, leading to complex and laborious design processes. Here, we report the synthesis of tyrosine (Tyr)-modified peptides-capped iodine (I) doped CuS nanoparticles (CuS-I@P1 NPs) as self-catalytic building blocks that undergo self-propelled assembly inside tumour cells via Tyr-Tyr condensation reactions catalyzed by the nanoparticles themselves. Upon cellular internalization, the CuS-I@P1 NPs undergo furin-guided condensation reactions, leading to the formation of CuS-I nanoparticle assemblies through dityrosine bond. The tumour-specific furin-instructed intracellular assembly of CuS-I NPs exhibits activatable dual-modal imaging capability and enhanced photothermal effect, enabling highly efficient imaging and therapy of tumours. The robust nanoparticle self-catalysis-regulated in situ assembly, facilitated by natural handles, offers the advantages of convenient fabrication, high reaction specificity, and biocompatibility, representing a generalizable strategy for target-specific activatable biomedical imaging and therapy. |
| first_indexed | 2024-03-08T14:13:57Z |
| format | Article |
| id | doaj.art-393af532c9f442928bed525f072b4580 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-03-08T14:13:57Z |
| publishDate | 2024-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-393af532c9f442928bed525f072b45802024-01-14T12:29:30ZengNature PortfolioNature Communications2041-17232024-01-0115111310.1038/s41467-024-44736-ySelf-propelled assembly of nanoparticles with self-catalytic regulation for tumour-specific imaging and therapyMengmeng Xia0Qiyue Wang1Yamin Liu2Chunyan Fang3Bo Zhang4Shengfei Yang5Fu Zhou6Peihua Lin7Mingzheng Gu8Canyu Huang9Xiaojun Zhang10Fangyuan Li11Hongying Liu12Guangfeng Wang13Daishun Ling14School of Chemistry and Materials Science, Anhui Province Key Laboratory of Biomedical Materials and Chemical Measurement, Center for Nano Science and Technology, Anhui Normal UniversityFrontiers Science Center for Transformative Molecules, School of Chemistry and Chemical Engineering, School of Biomedical Engineering, National Center for Translational Medicine, State Key Laboratory of Oncogenes and Related Genes, Shanghai Jiao Tong UniversityFrontiers Science Center for Transformative Molecules, School of Chemistry and Chemical Engineering, School of Biomedical Engineering, National Center for Translational Medicine, State Key Laboratory of Oncogenes and Related Genes, Shanghai Jiao Tong UniversityFrontiers Science Center for Transformative Molecules, School of Chemistry and Chemical Engineering, School of Biomedical Engineering, National Center for Translational Medicine, State Key Laboratory of Oncogenes and Related Genes, Shanghai Jiao Tong UniversityFrontiers Science Center for Transformative Molecules, School of Chemistry and Chemical Engineering, School of Biomedical Engineering, National Center for Translational Medicine, State Key Laboratory of Oncogenes and Related Genes, Shanghai Jiao Tong UniversityInstitute of Pharmaceutics, Hangzhou Institute of Innovative Medicine, College of Pharmaceutical Sciences, Zhejiang UniversitySchool of Chemistry and Materials Science, Anhui Province Key Laboratory of Biomedical Materials and Chemical Measurement, Center for Nano Science and Technology, Anhui Normal UniversityFrontiers Science Center for Transformative Molecules, School of Chemistry and Chemical Engineering, School of Biomedical Engineering, National Center for Translational Medicine, State Key Laboratory of Oncogenes and Related Genes, Shanghai Jiao Tong UniversitySchool of Chemistry and Materials Science, Anhui Province Key Laboratory of Biomedical Materials and Chemical Measurement, Center for Nano Science and Technology, Anhui Normal UniversityFrontiers Science Center for Transformative Molecules, School of Chemistry and Chemical Engineering, School of Biomedical Engineering, National Center for Translational Medicine, State Key Laboratory of Oncogenes and Related Genes, Shanghai Jiao Tong UniversitySchool of Chemistry and Materials Science, Anhui Province Key Laboratory of Biomedical Materials and Chemical Measurement, Center for Nano Science and Technology, Anhui Normal UniversityInstitute of Pharmaceutics, Hangzhou Institute of Innovative Medicine, College of Pharmaceutical Sciences, Zhejiang UniversityCollege of Automation, Hangzhou Dianzi UniversitySchool of Chemistry and Materials Science, Anhui Province Key Laboratory of Biomedical Materials and Chemical Measurement, Center for Nano Science and Technology, Anhui Normal UniversityFrontiers Science Center for Transformative Molecules, School of Chemistry and Chemical Engineering, School of Biomedical Engineering, National Center for Translational Medicine, State Key Laboratory of Oncogenes and Related Genes, Shanghai Jiao Tong UniversityAbstract Targeted assembly of nanoparticles in biological systems holds great promise for disease-specific imaging and therapy. However, the current manipulation of nanoparticle dynamics is primarily limited to organic pericyclic reactions, which necessitate the introduction of synthetic functional groups as bioorthogonal handles on the nanoparticles, leading to complex and laborious design processes. Here, we report the synthesis of tyrosine (Tyr)-modified peptides-capped iodine (I) doped CuS nanoparticles (CuS-I@P1 NPs) as self-catalytic building blocks that undergo self-propelled assembly inside tumour cells via Tyr-Tyr condensation reactions catalyzed by the nanoparticles themselves. Upon cellular internalization, the CuS-I@P1 NPs undergo furin-guided condensation reactions, leading to the formation of CuS-I nanoparticle assemblies through dityrosine bond. The tumour-specific furin-instructed intracellular assembly of CuS-I NPs exhibits activatable dual-modal imaging capability and enhanced photothermal effect, enabling highly efficient imaging and therapy of tumours. The robust nanoparticle self-catalysis-regulated in situ assembly, facilitated by natural handles, offers the advantages of convenient fabrication, high reaction specificity, and biocompatibility, representing a generalizable strategy for target-specific activatable biomedical imaging and therapy.https://doi.org/10.1038/s41467-024-44736-y |
| spellingShingle | Mengmeng Xia Qiyue Wang Yamin Liu Chunyan Fang Bo Zhang Shengfei Yang Fu Zhou Peihua Lin Mingzheng Gu Canyu Huang Xiaojun Zhang Fangyuan Li Hongying Liu Guangfeng Wang Daishun Ling Self-propelled assembly of nanoparticles with self-catalytic regulation for tumour-specific imaging and therapy Nature Communications |
| title | Self-propelled assembly of nanoparticles with self-catalytic regulation for tumour-specific imaging and therapy |
| title_full | Self-propelled assembly of nanoparticles with self-catalytic regulation for tumour-specific imaging and therapy |
| title_fullStr | Self-propelled assembly of nanoparticles with self-catalytic regulation for tumour-specific imaging and therapy |
| title_full_unstemmed | Self-propelled assembly of nanoparticles with self-catalytic regulation for tumour-specific imaging and therapy |
| title_short | Self-propelled assembly of nanoparticles with self-catalytic regulation for tumour-specific imaging and therapy |
| title_sort | self propelled assembly of nanoparticles with self catalytic regulation for tumour specific imaging and therapy |
| url | https://doi.org/10.1038/s41467-024-44736-y |
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