The Epithelial to Mesenchymal Transition in Colorectal Cancer Progression: The Emerging Role of Succinate Dehydrogenase Alterations and Succinate Accumulation

The Epithelial to Mesenchymal Transition in Colorectal Cancer Progression: The Emerging Role of Succinate Dehydrogenase Alterations and Succinate Accumulation

Colorectal cancer (CRC) stands as the third most significant contributor to cancer-related mortality worldwide. A major underlying reason is that the detection of CRC usually occurs at an advanced metastatic stage, rendering therapies ineffective. In the progression from the in situ neoplasia stage...

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Bibliographic Details
Main Authors: Mimmo Turano, Rosario Vicidomini, Francesca Cammarota, Valeria D’Agostino, Francesca Duraturo, Paola Izzo, Marina De Rosa
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Biomedicines
Subjects:
colorectal cancers (CRCs)
epithelial to mesenchymal transition (EMT)
succinate dehydrogenase (SDH)
succinate
metabolic reprogramming
Online Access:https://www.mdpi.com/2227-9059/11/5/1428

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