Mechanical Regulation of Nuclear Translocation in Migratory Neurons
Neuronal migration is a critical step during the formation of functional neural circuits in the brain. Newborn neurons need to move across long distances from the germinal zone to their individual sites of function; during their migration, they must often squeeze their large, stiff nuclei, against s...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-03-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fcell.2020.00150/full |
| _version_ | 1811322398319837184 |
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| author | Naotaka Nakazawa Mineko Kengaku Mineko Kengaku |
| author_facet | Naotaka Nakazawa Mineko Kengaku Mineko Kengaku |
| author_sort | Naotaka Nakazawa |
| collection | DOAJ |
| description | Neuronal migration is a critical step during the formation of functional neural circuits in the brain. Newborn neurons need to move across long distances from the germinal zone to their individual sites of function; during their migration, they must often squeeze their large, stiff nuclei, against strong mechanical stresses, through narrow spaces in developing brain tissue. Recent studies have clarified how actomyosin and microtubule motors generate mechanical forces in specific subcellular compartments and synergistically drive nuclear translocation in neurons. On the other hand, the mechanical properties of the surrounding tissues also contribute to their function as an adhesive support for cytoskeletal force transmission, while they also serve as a physical barrier to nuclear translocation. In this review, we discuss recent studies on nuclear migration in developing neurons, from both cell and mechanobiological viewpoints. |
| first_indexed | 2024-04-13T13:35:41Z |
| format | Article |
| id | doaj.art-393d7d9127944d68ac115ac04cfc42f7 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-04-13T13:35:41Z |
| publishDate | 2020-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-393d7d9127944d68ac115ac04cfc42f72022-12-22T02:44:48ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2020-03-01810.3389/fcell.2020.00150509252Mechanical Regulation of Nuclear Translocation in Migratory NeuronsNaotaka Nakazawa0Mineko Kengaku1Mineko Kengaku2Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University Institute for Advanced Study, Kyoto University, Kyoto, JapanInstitute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University Institute for Advanced Study, Kyoto University, Kyoto, JapanGraduate School of Biostudies, Kyoto University, Kyoto, JapanNeuronal migration is a critical step during the formation of functional neural circuits in the brain. Newborn neurons need to move across long distances from the germinal zone to their individual sites of function; during their migration, they must often squeeze their large, stiff nuclei, against strong mechanical stresses, through narrow spaces in developing brain tissue. Recent studies have clarified how actomyosin and microtubule motors generate mechanical forces in specific subcellular compartments and synergistically drive nuclear translocation in neurons. On the other hand, the mechanical properties of the surrounding tissues also contribute to their function as an adhesive support for cytoskeletal force transmission, while they also serve as a physical barrier to nuclear translocation. In this review, we discuss recent studies on nuclear migration in developing neurons, from both cell and mechanobiological viewpoints.https://www.frontiersin.org/article/10.3389/fcell.2020.00150/fullneuronal migrationnuclear translocationcytoskeletoncellular mechanicsactomyosinmicrotubule motors |
| spellingShingle | Naotaka Nakazawa Mineko Kengaku Mineko Kengaku Mechanical Regulation of Nuclear Translocation in Migratory Neurons Frontiers in Cell and Developmental Biology neuronal migration nuclear translocation cytoskeleton cellular mechanics actomyosin microtubule motors |
| title | Mechanical Regulation of Nuclear Translocation in Migratory Neurons |
| title_full | Mechanical Regulation of Nuclear Translocation in Migratory Neurons |
| title_fullStr | Mechanical Regulation of Nuclear Translocation in Migratory Neurons |
| title_full_unstemmed | Mechanical Regulation of Nuclear Translocation in Migratory Neurons |
| title_short | Mechanical Regulation of Nuclear Translocation in Migratory Neurons |
| title_sort | mechanical regulation of nuclear translocation in migratory neurons |
| topic | neuronal migration nuclear translocation cytoskeleton cellular mechanics actomyosin microtubule motors |
| url | https://www.frontiersin.org/article/10.3389/fcell.2020.00150/full |
| work_keys_str_mv | AT naotakanakazawa mechanicalregulationofnucleartranslocationinmigratoryneurons AT minekokengaku mechanicalregulationofnucleartranslocationinmigratoryneurons AT minekokengaku mechanicalregulationofnucleartranslocationinmigratoryneurons |