Stevens-Johnson syndrome and toxic epidermal necrolysis: epidemiological and clinical outcomes analysis in public hospitals
Abstract: Background: Adverse drug reactions are harmful and involuntary responses to drugs that occur at doses normally used for a given condition. Among them are Stevens-Johnson syndrome and toxic epidermal necrolysis, both rare and potentially fatal conditions. Objectives: To analyze the epidem...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Dermatologia
2017-10-01
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| Series: | Anais Brasileiros de Dermatologia |
| Subjects: | |
| Online Access: | http://www.scielo.br/pdf/abd/v92n5/0365-0596-abd-92-05-0661.pdf |
| _version_ | 1819002878210080768 |
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| author | Luana Bernardes Arantes Carmélia Santiago Reis Alice Garbi Novaes Marta Rodrigues de Carvalho Leila Bernarda Donato Göttems Maria Rita Carvalho Garbi Novaes |
| author_facet | Luana Bernardes Arantes Carmélia Santiago Reis Alice Garbi Novaes Marta Rodrigues de Carvalho Leila Bernarda Donato Göttems Maria Rita Carvalho Garbi Novaes |
| author_sort | Luana Bernardes Arantes |
| collection | DOAJ |
| description | Abstract: Background: Adverse drug reactions are harmful and involuntary responses to drugs that occur at doses normally used for a given condition. Among them are Stevens-Johnson syndrome and toxic epidermal necrolysis, both rare and potentially fatal conditions. Objectives: To analyze the epidemiological and clinical characteristics related to patients diagnosed with Stevens-Johnson syndrome and toxic epidermal necrolysis in public hospitals in the Federal District - Brazil. Methods: Retrospective, cross-sectional and descriptive study, in which data were collected referring to patients hospitalized in the public healthcare system of the Federal District from 1999 to 2014. Results: Between 1999 and 2014, 86 cases of hospitalized patients with diagnosis of Stevens-Johnson syndrome and toxic epidermal necrolysis in the Federal District were reported. The majority of patients were women; the most affected age group was 0 to 10 years. Patients older than 60 years (elderly) represent 6.98% of the cases. Most patients admitted to the referral hospital were discharged. However, occurrence of deaths exceeded that of discharge in elderly patients. Limitations of the study: There is fragility in the registry of hospitalization of patients, both in the hospital information system and in the medical records of the reference hospital. Conclusion: There is a need for greater production and better dissemination of information on the incidence of adverse drug reactions. |
| first_indexed | 2024-12-20T23:12:06Z |
| format | Article |
| id | doaj.art-3940e7c8aafc4d6ea1afa60d49cfaaba |
| institution | Directory Open Access Journal |
| issn | 0365-0596 |
| language | English |
| last_indexed | 2024-12-20T23:12:06Z |
| publishDate | 2017-10-01 |
| publisher | Sociedade Brasileira de Dermatologia |
| record_format | Article |
| series | Anais Brasileiros de Dermatologia |
| spelling | doaj.art-3940e7c8aafc4d6ea1afa60d49cfaaba2022-12-21T19:23:42ZengSociedade Brasileira de DermatologiaAnais Brasileiros de Dermatologia0365-05962017-10-0192566166710.1590/abd1806-4841.20176610Stevens-Johnson syndrome and toxic epidermal necrolysis: epidemiological and clinical outcomes analysis in public hospitalsLuana Bernardes ArantesCarmélia Santiago ReisAlice Garbi NovaesMarta Rodrigues de CarvalhoLeila Bernarda Donato GöttemsMaria Rita Carvalho Garbi NovaesAbstract: Background: Adverse drug reactions are harmful and involuntary responses to drugs that occur at doses normally used for a given condition. Among them are Stevens-Johnson syndrome and toxic epidermal necrolysis, both rare and potentially fatal conditions. Objectives: To analyze the epidemiological and clinical characteristics related to patients diagnosed with Stevens-Johnson syndrome and toxic epidermal necrolysis in public hospitals in the Federal District - Brazil. Methods: Retrospective, cross-sectional and descriptive study, in which data were collected referring to patients hospitalized in the public healthcare system of the Federal District from 1999 to 2014. Results: Between 1999 and 2014, 86 cases of hospitalized patients with diagnosis of Stevens-Johnson syndrome and toxic epidermal necrolysis in the Federal District were reported. The majority of patients were women; the most affected age group was 0 to 10 years. Patients older than 60 years (elderly) represent 6.98% of the cases. Most patients admitted to the referral hospital were discharged. However, occurrence of deaths exceeded that of discharge in elderly patients. Limitations of the study: There is fragility in the registry of hospitalization of patients, both in the hospital information system and in the medical records of the reference hospital. Conclusion: There is a need for greater production and better dissemination of information on the incidence of adverse drug reactions.http://www.scielo.br/pdf/abd/v92n5/0365-0596-abd-92-05-0661.pdfDrug eruptionsEpidemiologyStevens-Johnson syndrome |
| spellingShingle | Luana Bernardes Arantes Carmélia Santiago Reis Alice Garbi Novaes Marta Rodrigues de Carvalho Leila Bernarda Donato Göttems Maria Rita Carvalho Garbi Novaes Stevens-Johnson syndrome and toxic epidermal necrolysis: epidemiological and clinical outcomes analysis in public hospitals Anais Brasileiros de Dermatologia Drug eruptions Epidemiology Stevens-Johnson syndrome |
| title | Stevens-Johnson syndrome and toxic epidermal necrolysis: epidemiological and clinical outcomes analysis in public hospitals |
| title_full | Stevens-Johnson syndrome and toxic epidermal necrolysis: epidemiological and clinical outcomes analysis in public hospitals |
| title_fullStr | Stevens-Johnson syndrome and toxic epidermal necrolysis: epidemiological and clinical outcomes analysis in public hospitals |
| title_full_unstemmed | Stevens-Johnson syndrome and toxic epidermal necrolysis: epidemiological and clinical outcomes analysis in public hospitals |
| title_short | Stevens-Johnson syndrome and toxic epidermal necrolysis: epidemiological and clinical outcomes analysis in public hospitals |
| title_sort | stevens johnson syndrome and toxic epidermal necrolysis epidemiological and clinical outcomes analysis in public hospitals |
| topic | Drug eruptions Epidemiology Stevens-Johnson syndrome |
| url | http://www.scielo.br/pdf/abd/v92n5/0365-0596-abd-92-05-0661.pdf |
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