DNA methylation in the OPG/RANK/RANKL pathway is associated with steroid-induced osteonecrosis of the femoral head

DNA methylation in the OPG/RANK/RANKL pathway is associated with steroid-induced osteonecrosis of the femoral head

Abstract Background Dysregulation of the OPG/RANK/RANKL signalling pathway is a key step in the occurrence of steroid-induced osteonecrosis of the femoral head (ONFH). This study aims to understand the degree of methylation of the OPG, RANK, and RANKL genes in steroid-related ONFH. Methods A case-co...

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Bibliographic Details
Main Authors: Menghu Sun, Yuju Cao, Xiaolong Yang, Feimeng An, Huiqiang Wu, Jianzhong Wang
Format: Article
Language:English
Published: BMC 2021-06-01
Series:BMC Musculoskeletal Disorders
Subjects:
OPG
RANK
RANKL
Methylation
Steroid-induced ONFH
Online Access:https://doi.org/10.1186/s12891-021-04472-6

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