Starting at the endophenotype: A role for alpha-CaMKII in schizophrenia?
<p>Abstract</p> <p>Using an endophenotype-driven screen, a new study finds that α-calcium/calmodulin kinase II mutant mice exhibit a range of behavioral abnormalities related to schizophrenia. Perhaps most strikingly, this cluster of schizophrenia-related endophenotypes was associa...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2008-09-01
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| Series: | Molecular Brain |
| Online Access: | http://www.molecularbrain.com/content/1/1/5 |
| _version_ | 1818083971862364160 |
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| author | Frankland Paul W Sakaguchi Masanori Arruda-Carvalho Maithé |
| author_facet | Frankland Paul W Sakaguchi Masanori Arruda-Carvalho Maithé |
| author_sort | Frankland Paul W |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Using an endophenotype-driven screen, a new study finds that α-calcium/calmodulin kinase II mutant mice exhibit a range of behavioral abnormalities related to schizophrenia. Perhaps most strikingly, this cluster of schizophrenia-related endophenotypes was associated with abnormal neurogenesis in the adult hippocampus, raising the possibility that disrupted adult neurogenesis lies at the core of this and other psychiatric disorders.</p> |
| first_indexed | 2024-12-10T19:46:29Z |
| format | Article |
| id | doaj.art-39450df0b0384f0c9d06630863e0ef62 |
| institution | Directory Open Access Journal |
| issn | 1756-6606 |
| language | English |
| last_indexed | 2024-12-10T19:46:29Z |
| publishDate | 2008-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Brain |
| spelling | doaj.art-39450df0b0384f0c9d06630863e0ef622022-12-22T01:35:51ZengBMCMolecular Brain1756-66062008-09-0111510.1186/1756-6606-1-5Starting at the endophenotype: A role for alpha-CaMKII in schizophrenia?Frankland Paul WSakaguchi MasanoriArruda-Carvalho Maithé<p>Abstract</p> <p>Using an endophenotype-driven screen, a new study finds that α-calcium/calmodulin kinase II mutant mice exhibit a range of behavioral abnormalities related to schizophrenia. Perhaps most strikingly, this cluster of schizophrenia-related endophenotypes was associated with abnormal neurogenesis in the adult hippocampus, raising the possibility that disrupted adult neurogenesis lies at the core of this and other psychiatric disorders.</p>http://www.molecularbrain.com/content/1/1/5 |
| spellingShingle | Frankland Paul W Sakaguchi Masanori Arruda-Carvalho Maithé Starting at the endophenotype: A role for alpha-CaMKII in schizophrenia? Molecular Brain |
| title | Starting at the endophenotype: A role for alpha-CaMKII in schizophrenia? |
| title_full | Starting at the endophenotype: A role for alpha-CaMKII in schizophrenia? |
| title_fullStr | Starting at the endophenotype: A role for alpha-CaMKII in schizophrenia? |
| title_full_unstemmed | Starting at the endophenotype: A role for alpha-CaMKII in schizophrenia? |
| title_short | Starting at the endophenotype: A role for alpha-CaMKII in schizophrenia? |
| title_sort | starting at the endophenotype a role for alpha camkii in schizophrenia |
| url | http://www.molecularbrain.com/content/1/1/5 |
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