Strategies to promote abundance of Akkermansia muciniphila, an emerging probiotics in the gut, evidence from dietary intervention studies
Akkermansia muciniphila is a mucin-degrading bacterium commonly found in human gut. A. muciniphila has been inversely associated with obesity, diabetes, inflammation, and metabolic disorders. Due to its highly promising probiotic activities against obesity and diabetes, A. muciniphila has drawn inte...
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| Format: | Article |
| Language: | English |
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Elsevier
2017-06-01
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| Series: | Journal of Functional Foods |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464617301627 |
| _version_ | 1818598338121957376 |
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| author | Kequan Zhou |
| author_facet | Kequan Zhou |
| author_sort | Kequan Zhou |
| collection | DOAJ |
| description | Akkermansia muciniphila is a mucin-degrading bacterium commonly found in human gut. A. muciniphila has been inversely associated with obesity, diabetes, inflammation, and metabolic disorders. Due to its highly promising probiotic activities against obesity and diabetes, A. muciniphila has drawn intensive interest for research and development in recent years. A number of human and animal studies have shown that the abundance of A. muciniphila in the gut can be enhanced through dietary interventions. The present review focuses on evidence-based dietary strategies of improving A. muciniphila abundance in the gut by critically appraising up-to-date available human and animal intervention studies on A. muciniphila growth and their impact on risk factors of obesity and diabetes. Their potential mechanisms in promoting A. muciniphila are also discussed along with the discussions of mechanism of action for A. muciniphila to exert probiotic functions. |
| first_indexed | 2024-12-16T12:02:06Z |
| format | Article |
| id | doaj.art-3945b93d9a44475490c09c540f4505b0 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-16T12:02:06Z |
| publishDate | 2017-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-3945b93d9a44475490c09c540f4505b02022-12-21T22:32:25ZengElsevierJournal of Functional Foods1756-46462017-06-0133194201Strategies to promote abundance of Akkermansia muciniphila, an emerging probiotics in the gut, evidence from dietary intervention studiesKequan Zhou0Department of Nutrition & Food Science, Wayne State University, Detroit, MI 48202, USAAkkermansia muciniphila is a mucin-degrading bacterium commonly found in human gut. A. muciniphila has been inversely associated with obesity, diabetes, inflammation, and metabolic disorders. Due to its highly promising probiotic activities against obesity and diabetes, A. muciniphila has drawn intensive interest for research and development in recent years. A number of human and animal studies have shown that the abundance of A. muciniphila in the gut can be enhanced through dietary interventions. The present review focuses on evidence-based dietary strategies of improving A. muciniphila abundance in the gut by critically appraising up-to-date available human and animal intervention studies on A. muciniphila growth and their impact on risk factors of obesity and diabetes. Their potential mechanisms in promoting A. muciniphila are also discussed along with the discussions of mechanism of action for A. muciniphila to exert probiotic functions.http://www.sciencedirect.com/science/article/pii/S1756464617301627ProbioticsAkkermansia muciniphilaDietary supplementationGut microbiotaObesityDiabetes |
| spellingShingle | Kequan Zhou Strategies to promote abundance of Akkermansia muciniphila, an emerging probiotics in the gut, evidence from dietary intervention studies Journal of Functional Foods Probiotics Akkermansia muciniphila Dietary supplementation Gut microbiota Obesity Diabetes |
| title | Strategies to promote abundance of Akkermansia muciniphila, an emerging probiotics in the gut, evidence from dietary intervention studies |
| title_full | Strategies to promote abundance of Akkermansia muciniphila, an emerging probiotics in the gut, evidence from dietary intervention studies |
| title_fullStr | Strategies to promote abundance of Akkermansia muciniphila, an emerging probiotics in the gut, evidence from dietary intervention studies |
| title_full_unstemmed | Strategies to promote abundance of Akkermansia muciniphila, an emerging probiotics in the gut, evidence from dietary intervention studies |
| title_short | Strategies to promote abundance of Akkermansia muciniphila, an emerging probiotics in the gut, evidence from dietary intervention studies |
| title_sort | strategies to promote abundance of akkermansia muciniphila an emerging probiotics in the gut evidence from dietary intervention studies |
| topic | Probiotics Akkermansia muciniphila Dietary supplementation Gut microbiota Obesity Diabetes |
| url | http://www.sciencedirect.com/science/article/pii/S1756464617301627 |
| work_keys_str_mv | AT kequanzhou strategiestopromoteabundanceofakkermansiamuciniphilaanemergingprobioticsinthegutevidencefromdietaryinterventionstudies |